| Project/Area Number |
23659511
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Tohoku University |
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Principal Investigator |
TSUCHIYA Shigeru 東北大学, 大学院・医学系研究科, 名誉教授 (30124605)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Osamu 東北大学, 大学病院, 講師 (20333809)
UCHIYAMA Toru 東北大学, 大学病院, 助教 (10436107)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝子修復 / iPS 細胞 / OTC 欠損症 / iPS細胞 / OTC欠損症 |
|---|
| Research Abstract |
iPS cells was derived from fibroblasts of OTCD. While the cells were transduced with AAV targeting vector for the homologous recombination-mediated gene correction, corrected clones were not obtained. For making iPS cells, we developed the strategies of culturing keratinocytes from human hair. These cells can be passaged and cultured for a long time. The establishment of iPS cells using these cells is in progress.
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