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Genomic screening for Chlamydophila pneumoniae-specific antigens and development of vaccines

Research Project

Project/Area Number 23659528
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionKawasaki Medical School

Principal Investigator

OUCHI Kazunobu  川崎医科大学, 医学部, 教授 (80351899)

Co-Investigator(Kenkyū-buntansha) KISHI Fumio  川崎医科大学, 医学部, 教授 (40153077)
MIURA Koshiro  九州女子大学, 家政学部, 教授 (30284243)
YANATORI Izumi  川崎医科大学, 医学部, 講師 (40454847)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺炎クラミジア / 血清学診断法 / 血清学的診断法 / ワクチン
Research Abstract

To identify novel specific antigens from Chlamydophila pneumoniae, we screened 455 genes with unknown function in the genome of C. pneumoniae J138 by using serum samples from C. pneumoniae-infected patients. From this comprehensive analysis, 58 clones were identified as antigens. These results have provided useful information for the development of new serological tools for the diagnosis for C. pneumoniae infections and for the development of vaccines in future.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Genomic screening for Chlamydophila pneumoniae-specific antigens using serum samples from patients with primary infection2012

    • Author(s)
      Yasui Y, Yanatori I, Kawai Y, Miura K, Suminami Y, Hirota T, Tamari M, Ouchi K, Kishi F
    • Journal Title

      FEMS Microbiol Lett

      Volume: 329(2) Issue: 2 Pages: 168-76

    • DOI

      10.1111/j.1574-6968.2012.02520.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 宿主細胞の小胞輸送システムを制御する肺炎クラミジアエフェクター分子の探索2014

    • Author(s)
      安井ゆみこ, 簗取いずみ, 岸文雄
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2014-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] PACSIN2 に結合する肺炎クラミジア特異的エフェクター分子2013

    • Author(s)
      簗取 いずみ, 安井 ゆみこ, 三浦 公志郎, 岸 文雄
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Genomic screening for Chlamydophila pneumoniae antigens using sera from the patients2013

    • Author(s)
      Yasui Y, Yanatori I, Miura K, Ouchi K and Kishi F
    • Organizer
      CBRS 2013 : 6th Biennial Meeting of the Chlamydia Basic Research Society
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2013-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Screening for Chlamydophila pneumoniae antigens using sera from the primary-infection patients2012

    • Author(s)
      安井ゆみこ
    • Organizer
      第85回日本細菌学会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Related Report
      2011 Research-status Report
  • [Presentation] IDENTIFICATION OF CHLAMYDOPHILA PNEUMONIAE-SPECIFIC ANTIGENS USING SERA FROM CHILDREN ACUTE RESPIRATORY INFECTION2011

    • Author(s)
      Yasui Y, Yanatori I, Kawai y, Miura K, Katayama A, Ouchi K, and Kishi F
    • Organizer
      International Union of Microbiological Societies (IUMS) 2011 Congress
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2011-09-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺炎クラミジア特異抗原の網羅的スクリーニング2011

    • Author(s)
      安井ゆみこ、簗取いずみ、河合泰宏、三浦公志郎、尾内一信、岸文雄
    • Organizer
      第29回日本クラミジア研究会
    • Place of Presentation
      岐阜市
    • Year and Date
      2011-09-04
    • Related Report
      2013 Final Research Report
  • [Presentation] IDENTIFICATION OF CHLAMYDOPHILA PNEUMONIAE-SPECIFIC ANTIGENS USING SERA FROM CHILDREN ACUTE RESPIRATORY INFECTION2011

    • Author(s)
      Yasui Y. et al
    • Organizer
      International Union of Microbiological Societies (IUMS) 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] PACSIN2に結合する肺炎クラミジア特異的エフェクター分子

    • Author(s)
      簗取 いずみ
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 宿主細胞の小胞輸送システムを制御する肺炎クラミジアエフェクター分子の探索

    • Author(s)
      安井ゆみこ
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genomic screening for Chlamydophila pneumoniae antigens using sera from the patients

    • Author(s)
      安井ゆみこ、簗取いずみ、三浦公志郎、尾内一信、岸 文雄
    • Organizer
      CBRS 2013: 6th Biennial Meeting of the Chlamydia Basic Research Society
    • Place of Presentation
      Menger Hotel (San Antonio, TX,USA)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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