Molecular mechanism of TSLP production in keratinocytes in atopic dermatitis

• Project/Area Number: 23659546
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Nagoya University
• Principal Investigator: AKIYAMA Masashi 名古屋大学, 医学系研究科, 教授 (60222551)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: TSLP / アトピー性皮膚炎 / 小胞体ストレス応答 / フィラグリン / 表皮角化細胞 / Flaky tail mouse

Research Abstract

Thymic stromal lymphopoietin (TSLP) is one of the most important chemokine for pathogenesis of atopic dermatitis (AD), which is secreted by keratinocytes. However, which kinds of stimuli induce TSLP is not unidentified well. In this study, we suggested the unfolded protein response in keratinocytes induce TSLP.

Research Products

• [Journal Article] Paraneoplastic pemphigus with anti-laminin-332 autoantibodies in a patient with follicular dendritic cell sarcoma (2013)
  • Author(s): Sugiura K
  • Journal Title: JAMA Dermatol Volume: 149 Issue: 1 Pages: 111-113
  • DOI: 10.1001/2013.jamadermatol.512
  • Peer Reviewed
• [Journal Article] Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and with other systemic autoimmune rheumatic diseases (2013)
  • Author(s): Muro Y, Sugiura K, et al.
  • Journal Title: J Rheumatol Volume: 40 Issue: 1 Pages: 92-93
  • DOI: 10.3899/jrheum.121168
  • Peer Reviewed
• [Journal Article] Limitations of a single-point evaluation of anti-MDA5 antibody, ferritin, and IL-18 in predicting the prognosis of interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis (2013)
  • Author(s): Muro Y
  • Journal Title: Clin Rheumatol Volume: 32 Issue: 3 Pages: 395-398
  • DOI: 10.1007/s10067-012-2142-x
  • Peer Reviewed
• [Journal Article] Novel ABCA12 splice site deletion mutation and ABCA12 mRNA analysis of pulled hair samples in harlequin ichthyosis (2013)
  • Author(s): Takeichi T, Sugiura K, et al.
  • Journal Title: J Dermatol Sci Volume: 69 Issue: 3 Pages: 259-261
  • DOI: 10.1016/j.jdermsci.2012.11.004
  • Peer Reviewed
• [Journal Article] Low prevalence of autoantibodies to CENP-H, -I, -K, -L, -M, -N, -T and -U in a Japanese cohort of anti-centromere positive samples (2013)
  • Author(s): Saito A, Muro Y, Sugiura K, et al.
  • Journal Title: Immunopharmacol Immunotoxicol Volume: 35 Issue: 1 Pages: 57-63
  • DOI: 10.3109/08923973.2012.733707
  • Peer Reviewed
• [Journal Article] Perinatal cytomegalovirus-associated bullae in an immunocompetent infant (2012)
  • Author(s): Yasuda K, Sugiura K, et al.
  • Journal Title: Arch Dermatol Volume: 148 Issue: 6 Pages: 770-772
  • DOI: 10.1001/archdermatol.2011.3258
  • Peer Reviewed
• [Journal Article] Autoantibodies to nuclear matrix protein 2 /MJ in adult-onset dermatomyositis with severe calcinosis (2012)
  • Author(s): Sugiura K
  • Journal Title: J Am Acad Dermatol Volume: 67 Issue: 4 Pages: e167-e168
  • DOI: 10.1016/j.jaad.2012.01.015
  • Peer Reviewed
• [Journal Article] Development of an ELISA for detection of autoantibodies to nuclear matrix protein 2 (2012)
  • Author(s): Ishikawa A
  • Journal Title: Rheumatology (Oxford) Volume: 51 Issue: 7 Pages: 1181-1187
  • DOI: 10.1093/rheumatology/kes033
  • Peer Reviewed
• [Journal Article] Four novel ADAR1 gene mutations in patients with dyschromatosis symmetrica hereditaria (2012)
  • Author(s): Kono M, Akiyama M, Kondo T, Suzuki T, Suganuma M, Wataya-Kaneda M, Lam J, Shibaki A, Tomita Y
  • Journal Title: J Dermatol Volume: 39 Issue: 9 Pages: 819-21
  • DOI: 10.1111/j.1346-8138.2011.01385.x
  • Peer Reviewed
• [Journal Article] Drug eruption due to sodium picosulfate (2012)
  • Author(s): Ishikawa A
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 3 Pages: 410-411
  • DOI: 10.1684/ejd.2012.1679
  • Peer Reviewed
• [Journal Article] Clinical features of anti-TIF1-α antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-γ or anti-Mi-2 autoantibodies (2012)
  • Author(s): Muro Y
  • Journal Title: Rheumatology (Oxford) Volume: 51 Issue: 8 Pages: 1508-1513
  • DOI: 10.1093/rheumatology/kes073
  • Peer Reviewed
• [Journal Article] A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis (2012)
  • Author(s): Sugiura K
  • Journal Title: Br J Dermatol Volume: 167 Issue: 3 Pages: 699-701
  • DOI: 10.1111/j.1365-2133.2012.10953.x
  • Peer Reviewed
• [Journal Article] The β9 Loop Domain of PA-PLA(1)α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis (2012)
  • Author(s): Shinkuma S, Inoue A, Aoki J, Nishie W, Natsuga K, Ujiie H, Nomura T, Abe R, Akiyama M, Shimizu H
  • Journal Title: The Journal of Investigative Dermatology Volume: (印刷中) Issue: 8 Pages: 2093-2095
  • DOI: 10.1038/jid.2012.96
  • Peer Reviewed
• [Journal Article] Extraordinarily large protruding accessory breast cancer in a male (2012)
  • Author(s): Yoshida Y
  • Journal Title: J Am Acad Dermatol Volume: 67 Issue: 5 Pages: e230-e231
  • DOI: 10.1016/j.jaad.2012.04.034
  • Peer Reviewed
• [Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type (2012)
  • Author(s): Kabashima-Kubo R, Nakamura M, Sakabe, J, Sigita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
  • Journal Title: J Dermatol Sci Volume: 67 Issue: 1 Pages: 37-43
  • DOI: 10.1016/j.jdermsci.2012.04.004
  • Peer Reviewed
• [Journal Article] Severe chilblain lupus is associated with heterozygous missense mutations of catalytic amino acids or their adjacent in the exonuclease domains of 3'-repair exonuclease 1 (2012)
  • Author(s): Sugiura K
  • Journal Title: J Invest Dermatol Volume: 132 Issue: 12 Pages: 2855-2857
  • DOI: 10.1038/jid.2012.210
  • Peer Reviewed
• [Journal Article] Coexistence of pustular and vegetative pyoderma gangrenosum in a patient with myelodysplastic syndrome (2012)
  • Author(s): Omiya W
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 5 Pages: 1659-1671
  • DOI: 10.1684/ejd.2012.1813
  • Peer Reviewed
• [Journal Article] Type VII collagen deficiency causesdefective tooth enamel formation due to poor differentiation of ameloblasts (2012)
  • Author(s): Umemoto H, Akiyama M, Domon T, Nomura T, Shinkuma S, Ito K, Asaka T, Sawamura D, Uitto J, Uo M, Kitagawa Y, Shimizu H
  • Journal Title: Am J Pathol Volume: 181 Issue: 5 Pages: 1659-71
  • DOI: 10.1016/j.ajpath.2012.07.018
  • Peer Reviewed
• [Journal Article] Angiokeratoma of the scrotum and sublingual varices in a patient with jejunal phlebectasia (2012)
  • Author(s): Takama H
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 6 Pages: 818-819
  • DOI: 10.1684/ejd.2012.1868
  • Peer Reviewed
• [Journal Article] Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma (2012)
  • Author(s): Pohler E
  • Journal Title: Nat Genet Volume: 44 Issue: 11 Pages: 1272-1276
  • DOI: 10.1038/ng.2444
  • Peer Reviewed
• [Journal Article] AKT has an anti-apoptotic role in ABCA12-deficient keratinocytes. (2011)
  • Author(s): Yanagi T, Akiyama M, Nishihara H, Miyamura Y, Sakai K, Tanaka S, Shimizu H.
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 1942-1945
  • Peer Reviewed
• [Journal Article] Consequences of two different amino acid substitutions at the same codon in KRT14indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis (2011)
  • Author(s): Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DAD, Oiso N, Kawada A, Yoneda K, Akiyama M, Shimizu H
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 1869-1876
  • Peer Reviewed
• [Journal Article] Filaggrin gene defects and the risk of developing allergic disorders (2011)
  • Author(s): Osawa R, Akiyama M, Shimizu H
  • Journal Title: Allergol Int Volume: 60 Pages: 1-9
  • NAID: 10031143293
  • Peer Reviewed
• [Journal Article] The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis. (2011)
  • Author(s): Akiyama M
  • Journal Title: Dermato-Endocrinology Volume: 3 Pages: 107-112
  • Peer Reviewed
• [Journal Article] Updated molecular genetics and pathogenesis of ichthyoses (2011)
  • Author(s): Akiyama M
  • Journal Title: Nagoya J Med Sci Volume: 73 Pages: 79-90
  • NAID: 120003277468
  • Peer Reviewed
• [Journal Article] アトピー性皮膚炎の発症因子 フィラグリン遺伝子変異の全国調査 (2011)
  • Author(s): 秋山真志
  • Journal Title: 医薬の門 Volume: 51(1) Pages: 1-7
• [Journal Article] 皮膚科セミナリウム(第71回) 角化症 魚鱗癬と魚鱗癬症候群 (2011)
  • Author(s): 秋山真志
  • Journal Title: 日本皮膚科学会雑誌 Volume: 124(4) Pages: 667-673
• [Journal Article] アトピー性皮膚炎の病態と治療: アトピー性皮膚炎におけるフィラグリン遺伝子異常 (2011)
  • Author(s): 秋山真志
  • Journal Title: Derma Volume: 175 Pages: 1-6
• [Journal Article] Filaggrin gene defects and the risk of developing allergic disorders. (2011)
  • Author(s): Osawa R, Akiyama M, Shimizu H.
  • Journal Title: Allergol Int Volume: 60 Pages: 1-9
  • NAID: 10031143293
  • Peer Reviewed
• [Journal Article] LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT. (2011)
  • Author(s): Takeichi T, Kazumitsu Sugiura K, Muro Y, Ogawa Y, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 63 Pages: 203-205
  • NAID: 10030892614
  • Peer Reviewed
• [Presentation] ABC Proteins/Membrane Meso-domains/ES-iPS Cells (2012)
  • Author(s): Akiyama M
  • Organizer: ABCA12 and harlequin ichthyosis ABC Protein and Diseases ABC2011 in Kyoto
  • Place of Presentation: 京都
  • Year and Date: 2012-11-17
• [Presentation] 角層バリア機能異常症としての角化症とフィラグリン シンポジウム「Fillagrinとアトピー性皮膚炎」 (2012)
  • Author(s): 秋山真志
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2012-11-11
• [Presentation] 非免疫学因子の視点から:皮膚バリア機能との関わりについて シンポジウム「小児のアトピー性皮膚炎」 (2012)
  • Author(s): 秋山真志
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2012-11-10
• [Presentation] ヒト胎生期表皮における先天性魚鱗性様紅皮症の病因蛋白、NIPAL4,CYP4F22、lipoxigenase-3の発現パターンの検討 希少難治性皮膚疾患に関する調査研究班 (2011)
  • Author(s): 秋山真志
  • Organizer: 平成23年第2回総会
  • Place of Presentation: 東京都中央区
  • Year and Date: 2011-12-16
• [Presentation] 新規レジストリーとコホート調査の報告 希少難治性皮膚疾患に関する調査研究班 (2011)
  • Author(s): 秋山真志
  • Organizer: 平成23 年第2回総会
  • Place of Presentation: 東京都中央区
  • Year and Date: 2011-12-16
• [Presentation] アトピー性皮膚炎の病態と治療:皮膚バリア機能障害に着目して (2011)
  • Author(s): 秋山真志
  • Organizer: 日本アレルギー学会第40回教育セミナー
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2011-08-28
• [Presentation] 今、注目される遺伝性皮膚バリア障害 シンポジウム「遺伝性皮膚疾患」 (2011)
  • Author(s): 秋山真志
  • Organizer: 第35回日本小児皮膚科学会学術大会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-07-23
• [Presentation] アトピー性皮膚炎の発症因子としての日本人フィラグリン遺伝子変異 (2011)
  • Author(s): 秋山真志
  • Organizer: 第41回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 甲府市
  • Year and Date: 2011-07-17
• [Presentation] アトピー性皮膚炎と皮膚バリア機能～今、フィラグリンが注目されている理由 (2011)
  • Author(s): 秋山真志
  • Organizer: 第47回中部日本小児科学会 (招待講演)
  • Place of Presentation: 名古屋市
• [Presentation] アトピー性疾患の発症因子としての日本人フィラグリン遺伝子変異 (2011)
  • Author(s): 秋山真志
  • Organizer: 第41回日本皮膚アレルギー・接触皮膚炎学会総会学術大会(招待講演)
  • Place of Presentation: 甲府市
• [Presentation] 今、注目される遺伝性皮膚バリア障害 (2011)
  • Author(s): 秋山真志
  • Organizer: 第35回日本小児皮膚科学会学術大会(招待講演)
  • Place of Presentation: 横浜市
• [Presentation] 非免疫学的因子の視点から：皮膚バリア機能との関わりについて (2011)
  • Author(s): 秋山真志
  • Organizer: 第61回日本アレルギー学会秋季学術大会(招待講演)
  • Place of Presentation: 東京都港区
• [Presentation] 角層バリア機能異常症としての角化症とフィラグリン (2011)
  • Author(s): 秋山真志
  • Organizer: 第61回日本アレルギー学会秋季学術大会(招待講演)
  • Place of Presentation: 東京都港区
• [Presentation] 角化症診療のカッティング・エッジ 角化症の出生前診断up-to-date
  • Author(s): 秋山真志
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都国際会館
  • Invited
• [Presentation] 教育講習会、わかりやすい皮膚遺伝性疾患 遺伝性角化症とアトピー性皮膚炎
  • Author(s): 秋山真志
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都国際会館
  • Invited
• [Presentation] 教育講演、表皮の構造と機能
  • Author(s): 秋山真志
  • Organizer: 第30回日本美容皮膚科学会総会、学術大会
  • Place of Presentation: ウエスティンナゴヤキャッスルホテル
  • Invited
• [Presentation] 教育セミナー、皮膚アレルギーHot Topics アレルギー性疾患に対する皮膚角層バリア機能障害の関与を考える
  • Author(s): 秋山真志
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場
  • Invited
• [Presentation] 皮膚バリア障害から考えるアトピー性疾患の病態と治療法
  • Author(s): 秋山真志
  • Organizer: 平成24年度日本医師会主催生涯教育講座（皮膚科）
  • Place of Presentation: 愛知県医師会館地下講堂
  • Invited
• [Presentation] ランチプログラム、アトピー性皮膚炎のトピックス、アトピー性皮膚炎の発症とバリア機能
  • Author(s): 秋山真志
  • Organizer: 第24回日本アレルギー学会春季臨床大会
  • Place of Presentation: 大阪国際会議場
  • Invited
• [Presentation] ランチョンセミナー、アレルギー性疾患とフィラグリン遺伝子変異
  • Author(s): 秋山真志
  • Organizer: 第63回日本皮膚科学会中部支部学術大会
  • Place of Presentation: グランキューブ大阪
  • Invited
• [Presentation] イブニングセミナー、アトピー性皮膚炎と皮膚バリア機能障害
  • Author(s): 秋山真志
  • Organizer: 第63回日本皮膚科学会中部支部学術大会
  • Place of Presentation: グランキューブ大阪
  • Invited
• [Presentation] Sweets’ seminar、Stratum corneum barrier defects and atopic disorders; tight junctions
  • Author(s): Akiyama M
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇
  • Invited
• [Presentation] ABCA12機能障害による先天性魚鱗癬様紅皮症の発症機序の解明と治療法の開発
  • Author(s): 秋山真志
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成24年度第１回総会
  • Place of Presentation: KKRホテル東京
• [Presentation] 新規レジストリーとコホート調査の現状と今後の予定
  • Author(s): 秋山真志
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成24年度第１回総会
  • Place of Presentation: KKRホテル東京
• [Presentation] 新規レジストリーとコホート調査の現状と今後の予定
  • Author(s): 秋山真志
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成24年度第2回総会
  • Place of Presentation: KKRホテル東京
• [Book] 今日の治療指針2011年版 (2011)
  • Author(s): 秋山真志
  • Total Pages: 1031
  • Publisher: 医学書院
• [Remarks] 名古屋大学医学部皮膚科ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/derma/