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Molecular mechanism of urticarial development

Research Project

Project/Area Number 23659550
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

HIRAKAWA Satoshi  浜松医科大学, 医学部, 准教授 (50419511)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血管内皮細胞 / 細胞間接着 / シェディング / ヒスタミン / マイクロ流路 / シグナル伝達 / 酵素 / ヒスタミン受容体 / 治療
Research Abstract

The biochemical cleavage of VE-cadherin was found in cultured endothelial cells. Western blot analysis from cell lysates and conditioned media revealed that VE-cadherin undergoes ectodomain shedding in response to histamine, leading to the disruption of EC junctions and the induction of vascular hyperpermeability. These findings represent the development of urticaria, a pathological alteration of vasculature in the skin.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (39 results)

All 2013 2012 2011 2010 Other

All Journal Article (17 results) (of which Peer Reviewed: 7 results) Presentation (14 results) (of which Invited: 3 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis2012

    • Author(s)
      Asai J, Takenaka H, Hirakawa S, Sakabe J, Hagura A, Kishimoto S, Maruyama K, Kajiya K, Kinoshita S, Tokura Y , Katoh N.
    • Journal Title

      Am J Pathol

      Volume: 181 Pages: 2217-24

    • Related Report
      2012 Final Research Report
  • [Journal Article] Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator2012

    • Author(s)
      Liersch R, Hirakawa S, Berdel WE, Mesters RM, Detmar M
    • Journal Title

      Int J Oncol

      Volume: 41 Pages: 2073-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump2012

    • Author(s)
      Sasaki N, Shinjo M, Hirakawa S, Nishinaka M, Tanaka Y, Mawatari K, Kitamori T, Sato K
    • Journal Title

      Electrophoresis

      Volume: 33 Pages: 1729-1735

    • Related Report
      2012 Final Research Report
  • [Journal Article] Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B2012

    • Author(s)
      Okazaki H, Hirakawa S, Shudou M, Nakaoka Y, Shirakata Y, Miyata K, Oike Y,Hashimoto K, Sayama K.
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 366-74

    • NAID

      10031184909

    • Related Report
      2012 Final Research Report
  • [Journal Article] Targeted overexpression of Angpt16/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B2012

    • Author(s)
      Okazaki H, et al
    • Journal Title

      J Dermatol

      Volume: 39 Issue: 4 Pages: 366-74

    • DOI

      10.1111/j.1346-8138.2011.01396.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump.2012

    • Author(s)
      Naoki Sasaki
    • Journal Title

      Electrophoresis

      Volume: 33 Issue: 12 Pages: 1729-1735

    • DOI

      10.1002/elps.201100691

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator.2012

    • Author(s)
      Rudiger Liersch
    • Journal Title

      International Journal of Oncology

      Volume: 41 Issue: 6 Pages: 2073-2078

    • DOI

      10.3892/ijo.2012.1665

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Twist1 as a possible biomarker for metastatic basal cell carcinoma.2012

    • Author(s)
      Yuta Majima
    • Journal Title

      Acta Dermato-Venereologica

      Volume: 92 Issue: 6 Pages: 621-622

    • DOI

      10.2340/00015555-1422

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B2012

    • Author(s)
      Okazaki H, Hirakawa S, Shudou M, Nakaoka Y, Shirakata Y, Miyata K, Oike Y, Hashimoto K, Sayama K.
    • Journal Title

      Journal of Dermatology

      Volume: 39 Pages: 366-374

    • NAID

      10031184909

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis2011

    • Author(s)
      Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, Jinnin M, Ito T , Hirakawa S, Ihn H, Oike Y
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 7502-12

    • Related Report
      2012 Final Research Report
  • [Journal Article] Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse2011

    • Author(s)
      Kerjaschki D, Bago-Horvath Z, Rudas M, Sexl V, Schneckenleithner C, Wolbank S, Bartel G, Krieger S, Kalt R, Hantusch B, Keller T, Nagy-Bojarszky K, Huttary N, Raab I, Lackner K, Krautgasser K, Schachner H, Kaserer K, Rezar S, Madlener S, Vonach C, Davidovits A, Nosaka H, Hammerle M, Viola K, Dolznig H, Schreiber M, Nader A, Mikulits W, Gnant M, Hirakawa S, Detmar M, Alitalo K, Nijman S, Offner F, Maier TJ, Steinhilber D, Krupitza G
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 2000-12

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes2011

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Pages: 806-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] Raynaud's phenomenon, digital gangrene and hypergammaglobulinemic purpura occurring in a patient with IgG4-related disease2011

    • Author(s)
      Ikawa T, Kasuya A, Hirakawa S, Tokura Y
    • Journal Title

      Br J Dermatol

      Volume: 165 Issue: 6 Pages: 1359-1366

    • DOI

      10.1111/j.1365-2133.2011.10609.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple milia and comedones as a skin manifestation of systemic amyloidosis.2011

    • Author(s)
      Funai N, Machida S, Ito T, Hirakawa S, Tokura Y.
    • Journal Title

      European Journal of Dermatology

      Volume: 21 Pages: 638-639

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes2010

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 179-86

    • NAID

      10027841095

    • Related Report
      2012 Final Research Report
  • [Journal Article] E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.2010

    • Author(s)
      Sayama K, Yamamoto M, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K
    • Journal Title

      J Biol Chem

      Volume: 39 Pages: 30042-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice2010

    • Author(s)
      Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚と循環:血管・リンパ管から考える病態生理. シンポジウム:階層的循環システム構築の機序とその破綻2013

    • Author(s)
      平川 聡史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚と循環:血管・リンパ管から考える病態生理2013

    • Author(s)
      平川 聡史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚と循環:血管・リンパ管から考える病態生理2013

    • Author(s)
      平川聡史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A functional role of LYVE-1 in VEGF-A-induced lymphangiogenesis and psoriasis2012

    • Author(s)
      Hirakawa S.
    • Organizer
      The 61st annual Montania Symposium
    • Place of Presentation
      Gleneden Beach, Oregon
    • Related Report
      2012 Final Research Report
  • [Presentation] New approaches for patho-physiological function in cutaneous lymphatic vessels.2012

    • Author(s)
      平川聡史
    • Organizer
      第36回日本リンパ学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] An approach to fabricate the polymer hollow microneedle that targets dermal lymphatic vessels in the skin2012

    • Author(s)
      Satoshi Hirakawa
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      那覇
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A functional role of LYVE-1 in VEGF-A-induced lymphangiogenesis and psoriasis.2012

    • Author(s)
      Satoshi Hirakawa
    • Organizer
      The 61st annual Montania Symposium
    • Place of Presentation
      アメリカ合衆国
    • Related Report
      2012 Annual Research Report
  • [Presentation] リンパ管新生とリンパ節転移の基礎的解析2011

    • Author(s)
      平川 聡史
    • Organizer
      第35回日本リンパ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Pathological angiogenesis and lymphangiogenesis.2011

    • Author(s)
      Hirakawa S
    • Organizer
      World Congress of Dermatology 2011
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2011-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌とリンパ管新生2011

    • Author(s)
      平川 聡史
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Elevated expression of LYVE-1 in novel three-dimensional constructs by cultured dermal lymphatic endothelial cells.2011

    • Author(s)
      Hirakawa S, Kadowaki K, Matsusaki M, Akashi M, Tokura Y
    • Organizer
      The 36th annual meeting of the Society for Japanese Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Final Research Report
  • [Presentation] Pathological lymphangiogenesis requires VEGF-A for endothelial proliferation and migration.2011

    • Author(s)
      Hirakawa S
    • Organizer
      The 9th Japan-Korea Joint Symposium on Vascular Biology
    • Place of Presentation
      Busan, South Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Lymphatic vessels in inflammation and tumor metastasis2011

    • Author(s)
      Hirakawa S
    • Organizer
      8th International Symposium on the Biology of Endothelial cell
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2012 Final Research Report
  • [Presentation] Lymphatic vessels in inflammation and tumor metastasis2011

    • Author(s)
      平川聡史
    • Organizer
      EC8 Zurich 2011. 8th International Symposium on the Biology of Endothelial cell(招待講演)
    • Place of Presentation
      チューリッヒ
    • Related Report
      2011 Research-status Report
  • [Book] 慢性炎症におけるリンパ管新生2012

    • Author(s)
      平川 聡史
    • Publisher
      佐藤靖史(編集) 医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] 血管新生研究の最先端2012

    • Author(s)
      平川聡史
    • Total Pages
      6
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Annual Research Report
  • [Book] がん幹細胞2011

    • Author(s)
      平川聡史
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2011 Research-status Report
  • [Book] がん転移とリンパ管ニッチ

    • Author(s)
      平川 聡史
    • Publisher
      須田年生(編集) 羊土社
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1b/derm/achievements/index.html

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 血管透過性亢進抑制作用の評価法2013

    • Inventor(s)
      山内 豊彦、平川聡史、山下 豊、戸倉 新樹
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学・浜松ホトニクス株式会社
    • Industrial Property Number
      2013-034570
    • Filing Date
      2013-02-25
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許2013

    • Inventor(s)
      山内豊彦
    • Industrial Property Rights Holder
      山内豊彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-034570
    • Filing Date
      2013-02-25
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロニードルアレイ装置2011

    • Inventor(s)
      田丸卓也
    • Industrial Property Rights Holder
      田丸卓也
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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