| Project/Area Number |
23659556
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UTANI Atsushi 長崎大学, 医学部・皮膚科学講座, 教授 (10292707)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バーシカン / プロテオグリカン / 細胞外マトリックス / ノックアウトマウス / 毛包 / 遺伝子改変マウス / コンドロイチン硫酸 / グリコサミノグリカン |
|---|
| Research Abstract |
Versican (Vcan) is a large chondroitin sulfate proteoglycan of the extracellular matrix, which is transiently expressed in mesenchymal condensation areas such as cartilage primordium and dermal papilla. Here, we aimed to investigate the role of Vcan in development and maintenance of hair follicles. Though we performed intradermal injection of adenovirus expressing cre into Vcan<flox/flox> mice, we could not ablate its expression in dermal papilla cells. Currently, we are planning to generate Corin-cre; Vcan<flox/flox> mice, which lack Vcan expression in dermal papillae.
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