| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Human gingival cancer cells (Ca9-22 cells) harboring mutated p53 (mp53) gene were irradiated with 2 Gy of X-rays or Fe-ion beams. Akt-related protein levels decreased when cells were irradiated with high LET radiation. In addition, high LET radiation increased G2/M phase arrests and suppressed the progression of the cell cycle much more efficiently when compared to low LET radiation. These results suggest that high LET radiation enhances apoptosis and cell cycle arrest by suppressing Akt-related signals,even in the cancer cells bearing mp53 gene.
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