| Project/Area Number |
23659861
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Minoru 岩手医科大学, 歯学部, 准教授 (40187133)
KIMURA Shigenobu 岩手医科大学, 歯学部, 教授 (10177917)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 感染発癌 / AID / 口腔細菌 / 口腔癌 / Streptococcus anginosus / 炎症 / S. anginosus / 歯肉上皮細胞 / 口腔レンサ球菌 |
|---|
| Research Abstract |
Streptococcus anginosus infection could be closely related with oral squamous cellcarcinoma. Recent studies suggested that the aberrant expression of AID in the epithelial cells could re-sult in the generation of nucleotide alterations in tumor-related genes and possible malignant transforma-tion of the AID-expressing cells. In this study, the involvement of S. anginosus infection and the AID ex-pression in oral cancers was assessed. S. anginosus DNA was frequently detected in the oral squamous cell carcinoma, and the relatively higher AID expressions were observed in the cancerous region. The stimula- tion with S. anginosus antigens could induce the NF-kB activation and AID expression in cultured cell li- nes. Taken together, S. anginosus infection could be closely related with the AID expression in the oral squamous cell carcinoma.
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