Development of neuro-regeneration with Botulinum toxin
| Project/Area Number |
23659897
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | The University of Tokushima (2012)
Okayama University (2011) |
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Principal Investigator |
MATSUKA Yoshizo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90243477)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)
MATSUO Ryuji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157268)
OGUMA Keiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00002262)
YAMAMOTO Yumiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20403496)
KUMADA Ai 岡山大学, 岡山大学病院, 医員 (40610895)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ボツリヌス毒素 / 神経細胞 / 活性 / 長寿命化 / トレハロース / 海馬 / 三叉神経 |
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| Research Abstract |
Dissociated rat trigeminal ganglion somata were incubated with matrigel in 37℃ CO_2condition. Commercially available hippocampus neuron was used in this study. Neuronal change was observed and the neuron that incubated with type A Botulinum toxin was survived longer than control. Also, dendrite of the neuron with Rotulinum toxin was longer than control neuron.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay2012
Author(s)
Kumada A, Matsuka Y, Spigelman I, Maruhama K, Yamamoto Y, Neubert JK, Noland TA, Watanabe K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
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Journal Title
Journal of Oral Rehabilitation
Volume: 39
Issue: 1
Pages: 63-72
DOI
Related Report
Peer Reviewed
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[Presentation] Botulinum toxin endocytosis into trigeminal neurons alleviates neuropathic pain2013
Author(s)
Maruhama K, Matsuka Y, Yamamoto Y, Terayama R, Komi K, Ono M, Maekawa K, Kamioka H, Yamashiro T, Sugimoto T, Matsushita O, Kuboki T
Organizer
International Association for Dental Research
Place of Presentation
Washington State Convention Center (Seattle, USA)
Year and Date
2013-03-22
Related Report
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[Presentation] 神経毒素成分を精製した A 型ボツリヌス毒素の三叉神経への取り込みと輸送2012
Author(s)
丸〓功太郎, 松香芳三, 山本由弥子, 寺山隆司, 古味佳子, 大野充昭, 前川賢治, 上岡 寛, 山城 隆, 杉本朋貞, 松下 治, 小熊恵二, 窪木拓男
Organizer
日本口腔顔面痛学会
Place of Presentation
慶応大学(東京都)
Year and Date
2012-11-03
Related Report
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[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
Author(s)
Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
Organizer
Society for Neuroscience
Place of Presentation
Washington DC Convention Center (Washington DC, USA)
Year and Date
2011-11-15
Related Report
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[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
Author(s)
Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo Convention Center (北海道)
Year and Date
2011-09-09
Related Report
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[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
Author(s)
Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo
Related Report
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[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
Author(s)
Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
Organizer
Society for Neuroscience
Place of Presentation
Washington DC
Related Report
