Analysis of molecular forces for stem/progenitor cell homing in bone regeneration
| Project/Area Number |
23659915
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIBI Hideharu 名古屋大学, 大学院・医学系研究科, 准教授 (90345885)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | SDF-1 / 幹細胞 / 骨延長 / 血管内皮細胞 / 間葉系幹細胞 / 組織再生 / MCP-1 / 血管内皮前駆細胞 / 造血幹細胞 / 細胞集積 |
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| Research Abstract |
In distraction osteogenesis, SDF-1 plays an essential role in the reconstruction of the neovascular network. Blood flow in the distraction gap is reduced by SDF-1 suppression. Then, it was changed to endochondral ossification style from membranous ossification style. On the other hand, experimental results on SDF-1 over-expression experiments, possibilities to promote tissue regeneration by applying the migration cell system, a new medical device provided was suggested.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors2011
Author(s)
Fujo, M., Yamamoto, A#., Ando,Y., Shohara, R., Kinoshita, K., Kaneko, T., Hibi, H., Ueda (#correspondence)
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Journal Title
Bone
Volume: 49
Issue: 4
Pages: 693-700
DOI
Related Report
Peer Reviewed
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