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The regenerative therapy of the jaw by auto-transplantation of adipose-derived stem cells

Research Project

Project/Area Number 23659956
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionShowa University

Principal Investigator

SHINTANI Satoru  昭和大学, 歯学部, 教授 (80294429)

Co-Investigator(Kenkyū-buntansha) KONDO Seiji  昭和大学, 歯学部, 准教授 (10432634)
MUKUDAI Yoshiki  昭和大学, 歯学部, 助教 (50325099)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords脂肪幹細胞 / 骨芽細胞 / 軟骨細胞 / 低侵襲性医療 / 骨再生 / 骨 / 軟骨 / 自家移植
Research Abstract

In the present study, we revealed as followed.
1) The advantages of chemical and mechanicalstress and a cobimation of those on human adipose-derived stem cells (ADSCs) have been revealed. 2) By the transplanation of the diffentiated ADSCs to nude mice, the histochmical and mmolecular-biological investigations of the transplants, wich was succesfully differntiated into bone tissue, have been carried out. 3) It has been suggested that the therapy might contribute the nobel and advantageous regenerative medicine for bone defect of the jaws, since the study was not utilize gene transfection like iPS cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro2014

    • Author(s)
      Mukudai, Y, Kondo, S., Koyama, T., Li C., Banka, S., Kogure, A., Yazawa, K., Shintani, S
    • Journal Title

      BMC Complement Altern Med

      Volume: 14 Pages: 29-29

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of vascular endothelial growth factor in high- and low-metastasis cell lines of salivary gland adenoid cystic carcinoma2014

    • Author(s)
      Kondo, S., Mukudai, Y., Soga, D., Nishida, T., Takigawa, M., Shirota
    • Journal Title

      Anticancer Res

      Volume: 34 Pages: 671-677

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro.2014

    • Author(s)
      *Mukudai, Y, Kondo, S., Koyama, T., Li C., Banka, S., Kogure, A., Yazawa, K., Shintani, S.
    • Journal Title

      BMC Complement Altern Med.

      Volume: 14 Issue: 1 Pages: 29-29

    • DOI

      10.1186/1472-6882-14-29

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The root bark extracts of Juncus effusuc and Paeonia suffruticosa protect salivary gland acinar cells from apoptotic cell death induced by cis-platinum (II) diammine dichloride2013

    • Author(s)
      Mukudai, Y., Kondo, S., Shiogama, S., Koyama, T., Li, C., Yazawa, K., Shintani, S
    • Journal Title

      Oncol Rep

      Volume: 30 Pages: 2665-71

    • Related Report
      2013 Final Research Report
  • [Journal Article] The root bark extracts of Juncus effusuc and Paeonia suffruticosa protect salivary gland acinar cells from apoptotic cell death induced by cis-platinum (II) diammine dichloride2013

    • Author(s)
      Mukudai, Y., Kondo, S., Shiogama, S., Koyama, T., Li, C., Yazawa, K., Shintani, S
    • Journal Title

      Oncol Rep.

      Volume: 30 Pages: 2665-2671

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on humanoral squamous cell carcinoma cells2013

    • Author(s)
      Sato D, Yazawa K, Kondo S, Mukudai Y, Li C,Kamatani T, Katsuta H, Yoshihama Y,Shirota T,Shintani S
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 1 Issue: 1 Pages: 105-111

    • DOI

      10.3892/mco.2012.14

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A combination of chemical and mechanical stimuli enhances not only osteo-but also chondro-differentiation in adipose-derived stem cells2012

    • Author(s)
      Banka, S., Mukudai, Y., Yoshihama, Y., Shirota, T., Kondo, S., Shintani, S
    • Journal Title

      J. Oral Biosci

      Volume: 54(7) Pages: 188-195

    • Related Report
      2013 Final Research Report
  • [Journal Article] The root bark of Paeonia moutan is a potential anticancer agent in human oral squamous cell carcinoma cells2012

    • Author(s)
      Li C, Yazawa K, Kondo S, Mukudai Y, Sato D, Kurihara Y, Kamatani T, Shintani S
    • Journal Title

      Anticancer research

      Volume: 32 Pages: 2625-2630

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A combination of chemical and mechanical stimuli enhances not only osteo-but also chondro-differentiation in adipose-derived cells2012

    • Author(s)
      Banka S, Mukudai Y, Yoshihama Y, Shirota T, Kondo S, Shintani S
    • Journal Title

      Journal of oral Biosciences

      Volume: 54 Pages: 188-195

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] A combination of chemical and mechanical stimuli synergistically enhances osteo-and chondro-differentation on adipose-derived stem cells2012

    • Author(s)
      Shintani S, Banka S, Mukudai Y, Kondo S
    • Organizer
      21 Congress of the European Association for Cranio-Maxillofacial Surgery
    • Place of Presentation
      Dubrovnik, Croatia
    • Related Report
      2012 Research-status Report
  • [Presentation] Mandibular reconstruction using an autoclave autogenous bone and Iliac particulate cancellous bone and marrow (PCBM)2012

    • Author(s)
      Shintani S, Kutsuna T, Yoshiba S, Kurihara Y, Yoshizawa Y, Yoshihama Y, Kondo S, Shirota T
    • Organizer
      Asian ACOMS
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂肪幹細胞(ADSC)から骨形成細胞への分化に対する化学的、機械的刺激の影響

    • Author(s)
      番家政香, 椋代義樹, 近藤誠二, 新谷悟
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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