|Budget Amount *help
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
|Outline of Final Research Achievements
Oligodendrocytes can respond to neuronal activity with prolonged depolarization of membrane potential. To understand the functional significance of oligodendrocytic depolarization, we used transgenic animals in which oligodendrocytes expressed channelrhodopsin-2 and examined the neuronal responses. We demonstrated that illumination-triggered depolarization of oligodendrocytes induced early- and late-onset facilitation of axonal conduction; the former lasted for approximately 10 min, whereas the latter continued for up to 3 h. These results suggested that oligodendrocyte depolarization induces short- and long-term functional plastic changes in the white matter and plays active roles in brain circuit functions.