High-dense CMOS electrode array to investigate neuronal network in culture
Project/Area Number |
23680050
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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Keywords | 神経細胞 / 脳 / ネットワーク / 培養 / 電極 / CMOS / 可塑性 / 神経回路 / 微小電極アレイ / カルシウムイメージング / 分散培養 / 活動電位 |
Research Abstract |
The network configuration and activities in dissociated cultures of neurons were investigated using high-density CMOS microelectrode array with 11,011 recording sites within 1.8 x 1.8 mm2. Our data demonstrated that the conduction velocity of action potential along an axon varies within an identical cell; the velocity was high at thick parts of axon, while low at thin parts. We also demonstrated that low-firing-rate neurons migrate actively. Furthermore, spatio-temporal patterns evoked by single axon stimulation were proved useful to quantify the functional connectivity and plasticity within the network.
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Report
(4 results)
Research Products
(34 results)
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[Presentation] Electrical imaging of axon function
Author(s)
Douglas J. Bakkum, Urs Frey, Milos Radivojevic, Thomas L. Russell, Jan Muller, Michele Fiscella, Hirokazu Takahashi, Andreas Hierlemann
Organizer
3rd International Symposium on Frontiers in Neurophotonics International Symposium
Place of Presentation
Bordeaux, France
Related Report
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