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Development of biofabrication techniques for living cells towards cell and tissue engineering

Research Project

Project/Area Number 23681027
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Microdevices/Nanodevices
Research InstitutionTohoku University

Principal Investigator

KAJI Hirokazu  東北大学, 工学(系)研究科(研究院), 准教授 (70431525)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywordsバイオファブリケーション / 生体材料 / マイクロ・ナノデバイス / 細胞・組織
Research Abstract

Developing fabrication process under physiological conditions is of significance in order to utilize the maximum function of biosources such as proteins and living cells. In this project, biofabrication techniques to endure the fragility of living cells were developed towards in vitro cell and tissue engineering. The combination of microfluidic technique, soft lithographic technique, and surface engineering with hydrogels and polymeric nanosheets enabled the development of 2D and 3D cell culture systems capable of controlling cellular environments and it is demonstrated that these systems are useful for the formation of functional tissues including muscles.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (65 results)

All 2014 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results,  Open Access: 1 results) Presentation (28 results) (of which Invited: 3 results) Book (14 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] A Platform for Controlled Dual-Drug Delivery to the Retina : Protective Effects against Light-Induced Retinal Damage in Rats2014

    • Author(s)
      N Nagai, H Kaji, H Onami, Y Katsukura, Y Ishikawa, ZK Nezhad, K Sampei, S Iwata, S Ito, M Nishizawa, T Nakazawa, N Osumi, Y Mashima, T Abe
    • Journal Title

      Advanced Healthcare Materials

      Volume: in press Issue: 10 Pages: 680-687

    • DOI

      10.1002/adhm.201400114

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices2014

    • Author(s)
      Kuniaki Nagamine, Kohei Okamoto, Hirokazu Kaji, Matsuhiko Nishizawa
    • Journal Title

      J. Biosci. Bioeng.

      Volume: (in press) Issue: 1 Pages: 94-97

    • DOI

      10.1016/j.jbiosc.2013.12.024

    • NAID

      110009838776

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Skeletal muscle tissue engineering: Methods to form skeletal myotubes and their applications2014

    • Author(s)
      Serge Ostrovidov, Vahid Hosseini, Samad Ahadian, Toshinori Fujie, S. Prakash Parthiban, Murugan Ramalingam, Hojae Bae, Hirokazu Kaji, Ali Khademhosseini
    • Journal Title

      Tissue Eng. B

      Volume: (in press) Issue: 5 Pages: 403-436

    • DOI

      10.1089/ten.teb.2013.0534

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films2014

    • Author(s)
      Samad Ahadian, Javier Ramón-Azcón, Haixin Chang, Xiaobin Liang, Hirokazu Kaji, Hitoshi Shiku, Ken Nakajima, Murugan Ramalingam, Hongkai Wu, Tomokazu Matsue, Ali Khademhosseini
    • Journal Title

      RSC Advances

      Volume: 4 Issue: 19 Pages: 9534-9541

    • DOI

      10.1039/c3ra46218h

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogel-based bioassay sheets for in vitro evaluation of contraction-dependent metabolic regulation in skeletal muscle cells2014

    • Author(s)
      Kuniaki Nagamine, Kohei Okamoto, Shingo Otani, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa
    • Journal Title

      Biomater. Sci.

      Volume: 2 Issue: 2 Pages: 252-256

    • DOI

      10.1039/c3bm60179j

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer2014

    • Author(s)
      Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji
    • Journal Title

      Adv. Mater

      Volume: 26 Issue: 29 Pages: 1699-1705

    • DOI

      10.1002/adma.201301300

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye2014

    • Author(s)
      Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yumi Ishikawa, Matsuhiko Nishizawa, Noriko Osumi, Toru Nakazawa, Toshiaki Abe
    • Journal Title

      Acta Biomaterialia

      Volume: 10(2) Issue: 2 Pages: 680-6877

    • DOI

      10.1016/j.actbio.2013.11.004

    • NAID

      40020425298

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrical stimulation as a biomimicry tool for regulating muscle cell behavior2013

    • Author(s)
      Samad Ahadian, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Murugan Ramalingam, Hojae Bae, Ali Khademhosseini
    • Journal Title

      Organogenesis

      Volume: 9 Issue: 2 Pages: 87-92

    • DOI

      10.4161/org.25121

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Engineered nanomembranes for directing cellular organization towards flexible biodevices2013

    • Author(s)
      Toshinori Fujie, Samad Ahadian, Hao Liu, Haixin Chang, Serge Ostrovidov, Hongkai Wu, Hojae Bae, Ken Nakajima, Hirokazu Kaji, Ali Khademhosseini
    • Journal Title

      Nano Lett.

      Volume: 13 Issue: 7 Pages: 3185-3192

    • DOI

      10.1021/nl401237s

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transscleral sustained vasohibin-1 delivery by a novel device suppressed experimentally-induced choroidal neovascularization2013

    • Author(s)
      Hideyuki Onami, Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Yasufumi Sato, Noriko Osumi, Toru Nakazawa, Toshiaki Abe
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 3 Pages: e58580-e58580

    • DOI

      10.1371/journal.pone.0058580

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A contactless electrical stimulator: application to fabricate functional skeletal muscle tissue2013

    • Author(s)
      Samad Ahadian, Javier Ramón-Azcón, Serge Ostrovidov, Gulden Camci-Unal, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue
    • Journal Title

      Biomed. Microdevices

      Volume: 15 Issue: 1 Pages: 109-115

    • DOI

      10.1007/s10544-012-9692-1

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue2012

    • Author(s)
      Samad Ahadian, Javier Ramón-Azcón, Serge Ostrovidov, Gulden Camci-Unal, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue
    • Journal Title

      Lab Chip

      Volume: 12 Issue: 18 Pages: 3491-3503

    • DOI

      10.1039/c2lc40479f

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells2012

    • Author(s)
      Javier Ramón-Azcón, Samad Ahadian, Raquel Obregón, Gulden Camci-Unal, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue
    • Journal Title

      Lab Chip

      Volume: 12 Issue: 16 Pages: 2959-2969

    • DOI

      10.1039/c2lc40213k

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Engineered contractile skeletal muscle tissue on a microgrooved methacrylated gelatin substrate2012

    • Author(s)
      Vahid Hosseini, Samad Ahadian, Serge Ostrovidov, Gulden Camci-Unal, Song Chen, Hirokazu Kaji, Murugan Ramalingam, Ali Khademhosseini
    • Journal Title

      Tissue Eng. A

      Volume: 18 Issue: 23-24 Pages: 2453-2465

    • DOI

      10.1089/ten.tea.2012.0181

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlled release of drugs from gradient hydrogels for high throughput analysis of cell/drug interactions2012

    • Author(s)
      Serge Ostrovidov, Nasim Annabi, Azadeh Seidi, Murugan Ramalingam, Fariba Dehghani, Hirokazu Kaji, Ali Khademhosseini
    • Journal Title

      Anal. Chem.

      Volume: 84 Issue: 3 Pages: 1302-1309

    • DOI

      10.1021/ac202256c

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Designer hydrophilic regions regulate droplet shape for controlled surface patterning and 3D capillary lithography2012

    • Author(s)
      Matthew J. Hancock, Fumiki Yanagawa, Yun-Ho Jang, Jiankang He, Nezamoddin N. Kachouie, Hirokazu Kaji, Ali Khademhosseini
    • Journal Title

      Small (Inside front cover article, also featured in Materials Views by Carol Stanier, Dec. 13, 2011)

      Volume: 8 Issue: 3 Pages: 393-403

    • DOI

      10.1002/smll.201101745

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomimetic tissues on a chip for drug discovery2012

    • Author(s)
      Amir M. Ghaemmaghami, Matthew J. Hancock, Helen Harrington, Hirokazu Kaji, Ali Khademhosseini
    • Journal Title

      Drug Discov. Today

      Volume: 17 Issue: 3-4 Pages: 173-181

    • DOI

      10.1016/j.drudis.2011.10.029

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease2011

    • Author(s)
      Azadeh Seidi, Hirokazu Kaji, Nasim Annabi, Serge Ostrovidov, Murugan Ramalingam, Ali Khademhosseini
    • Journal Title

      Biomicrofluidics

      Volume: 5 Issue: 2 Pages: 22214-22214

    • DOI

      10.1063/1.3580756

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Khademhosseini, Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs2011

    • Author(s)
      F. Yanagawa, H. Kaji, Y. H. Jang, H. Bae, D. Yanan, J. Fukuda, H. Qi, A.
    • Journal Title

      Khademhosseini, Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs

      Volume: 97A (1) Issue: 1 Pages: 93-102

    • DOI

      10.1002/jbm.a.33034

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A scalable controlled-release device for transscleral drug delivery to the retina2011

    • Author(s)
      Takeaki Kawashima, Nobuhiro Nagai, Hirokazu Kaji, Norihiro Kumasaka, Hideyuki Onami, Yumi Ishikawa, Noriko Osumi, Matsuhiko Nishizawa, Toshiaki Abe
    • Journal Title

      Biomaterials

      Volume: 32 Issue: 7 Pages: 1950-1956

    • DOI

      10.1016/j.biomaterials.2010.11.006

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions2011

    • Author(s)
      Hirokazu Kaji, Gulden Camci-Unal, Robert Langer, Ali Khademhosseini
    • Journal Title

      Biochim. Biophys. Acta-Gen. Subj.

      Volume: 1810 Issue: 3 Pages: 239-250

    • DOI

      10.1016/j.bbagen.2010.07.002

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 眼科領域におけるマイクロ・ナノ技術応用2014

    • Author(s)
      梶 弘和
    • Organizer
      第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台(基調講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] 眼科領域におけるマイクロ・ナノ技術応用2014

    • Author(s)
      梶 弘和
    • Organizer
      第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マイクロ流路デバイスを用いた眼底組織模倣チップの開発2013

    • Author(s)
      伊藤俊太郎, 永井典裕, 長峯邦明, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      日本機械学会東北支部第48 期総会・講演会
    • Place of Presentation
      仙台(独創研究学生賞受賞)
    • Year and Date
      2013-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] マイクロ流体デバイスを用いる眼底組織培養モデルの開発2013

    • Author(s)
      梶 弘和
    • Organizer
      日本動物実験代替法学会第26回大会
    • Place of Presentation
      京都テルサ
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Polymeric ultra-thin films for local delivery of cell monolayer2013

    • Author(s)
      Yoshinori Mori, Toshinori Fujie, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji
    • Organizer
      12th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      Maui, USA
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Development of a cell-based model of the ocular fundus within a microfluidic device2013

    • Author(s)
      Syuntaro Ito, Shunichi Tsunajima, Toshinori Fujie, Nobuhiro Nagai, Kuniaki Nagamine, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
    • Organizer
      12th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      Maui, USA
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] バルジ試験器機構を利用した上皮細胞への力学的負荷システムの開発2013

    • Author(s)
      綱嶋俊一, 伊藤俊太郎, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      化学とマイクロ・ナノシステム学会第28回研究会
    • Place of Presentation
      姫路
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ナノシートを用いる細胞送達システムの開発2013

    • Author(s)
      森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      船堀(ハイライト講演に選定)
    • Related Report
      2013 Final Research Report
  • [Presentation] 眼底組織モデル構築に向けたマイクロ流路デバイスの開発2013

    • Author(s)
      伊藤俊太郎, 綱島俊一,藤枝俊宣, 永井展裕, 長峯邦明, 西澤松彦, 阿部俊明, 梶弘和
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      船堀
    • Related Report
      2013 Final Research Report
  • [Presentation] Retinal pigment epithelial cells supported by polymeric ultra-thin films for the subretinal delivery2013

    • Author(s)
      Hirokazu Kaji, Toshinori Fujie, Yoshihiro Mori, Nobuhiro Nagai, Matsuhiko Nishizawa, Ali Khademhosseini, Toshiaki Abe
    • Organizer
      International Soft Matter Conference 2013
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] バイオファブリケーション技術の開発と眼科領域における医工連携2013

    • Author(s)
      梶 弘和
    • Organizer
      生体分子集合科学研究室夏季セミナー
    • Place of Presentation
      鴨川
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己支持性ナノ薄膜を用いた細胞デリバリー療法の開発2013

    • Author(s)
      梶 弘和, 森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明
    • Organizer
      第29回DDS 学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Flexible nanomembranes for directing cellular organization2013

    • Author(s)
      Toshinori Fujie, Hao Liu, Ken Nakajima, Hirokazu Kaji, Ali Khademhosseini
    • Organizer
      International Soft Matter Conference 2013
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] ナノシートによる細胞輸送システムの開発2013

    • Author(s)
      森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      化学とマイクロ・ナノシステム学会第28回研究会
    • Place of Presentation
      姫路
    • Related Report
      2013 Annual Research Report
  • [Presentation] ナノシートを用いる細胞送達システムの開発2013

    • Author(s)
      森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自己支持性ナノ薄膜を用いた細胞デリバリー療法の開発2013

    • Author(s)
      梶 弘和, 森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明
    • Organizer
      第29回DDS学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 網膜変性疾患治療を目指したインプラント型薬剤徐放システム2012

    • Author(s)
      梶 弘和
    • Organizer
      バイオジャパン2012
    • Place of Presentation
      横浜(受賞講演)
    • Year and Date
      2012-10-10
    • Related Report
      2013 Final Research Report
  • [Presentation] マイクロ流体デバイスを用いる眼底組織培養モデルの開発2012

    • Author(s)
      梶 弘和
    • Organizer
      日本動物実験代替法学会第25回大会
    • Place of Presentation
      慶応義塾大学薬学部芝共立キャンパス
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] An implantable drug delivery device for treating retinal disorders2012

    • Author(s)
      Hirokazu Kaji, Nobuhiro Nagai, Takuya Yamada, Matsuhiko Nishizawa, Toshiaki Abe
    • Organizer
      IEEE-EMBSMicro- and Nanoengineering in Medicine Conference
    • Place of Presentation
      Maui, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] バイオファブリケーション技術の開発とオーガンチップデバイスへの展開2012

    • Author(s)
      梶 弘和
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] 任意の細胞・組織配列を有する機能性バイオハイブリッド界面の構築2012

    • Author(s)
      藤枝俊宣, Ahadian Samad, Liu Hao, 中嶋健, Ostrovidov Serge, S. Prakash Parthiban,梶 弘和, Khademhosseini Ali
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Biofabrication techniques for biologically relevant tissue models and drug delivery devices2012

    • Author(s)
      Hirokazu Kaji
    • Organizer
      23rd 2012 International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      Nagoya, Japan (invited)
    • Related Report
      2013 Final Research Report
  • [Presentation] A controlled-release capsule device for transscleral drug delivery to the retina2012

    • Author(s)
      Hirokazu Kaji, Nobuhiro Nagai, Takuya Yamada, Matsuhiko Nishizawa, Toshiaki Abe
    • Organizer
      TAS 2012
    • Place of Presentation
      Okinawa, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 薬剤濃度勾配を有するハイドロゲルの作製と評価2012

    • Author(s)
      梶 弘和, Serge Ostrovidov, Ali Khademhosseini
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Biofabrication techniques for biologically relevant tissue models and drug delivery devices2012

    • Author(s)
      Hirokazu Kaji
    • Organizer
      23rd 2012 International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      Nagoya
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Organ-on-a-Chip 開発研究の国際動向2011

    • Author(s)
      梶 弘和
    • Organizer
      日本動物実験代替法学会第24回大会
    • Place of Presentation
      仙台(依頼講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] Organ-on-a-Chip開発研究の国際動向2011

    • Author(s)
      梶弘和
    • Organizer
      日本動物実験代替法学会第24回大会
    • Place of Presentation
      仙台(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高分子ナノ薄膜を用いる細胞送達システムの開発

    • Author(s)
      梶 弘和, 藤枝俊宣, 森 好弘, 永井典裕, 西澤松彦, 阿部俊明
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Book] "Bioinspired Muscle Tissue Devices" In Handbook of Biomimetics and Bioinspiration: 3 Volume Set, E. Jabbari, A. Khademhosseini, L. P. Lee, D.-H. Kim, A. Ghaemmaghami Eds.2014

    • Author(s)
      Toshinori Fujie, Serge Ostrovidov, Samad Ahadian, S. Prakash Parthiban, Ali Khademhosseini, Hirokazu Kaji
    • Publisher
      World Scientific Publishing
    • Related Report
      2013 Final Research Report
  • [Book] "Microfluidic systems for controlling stem cell microenvironments" In Microfluidic Cell Culture Systems, 2nd Edition, J. T. Borenstein, C. J. Bettinger, S. L. Tao, Eds.2014

    • Author(s)
      Seila Selimovic, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini
    • Publisher
      Elsevier Publishing (in press)
    • Related Report
      2013 Final Research Report
  • [Book] “Bioinspired Muscle Tissue Devices” In Handbook of Biomimetics and Bioinspiration: 3 Volume Set2014

    • Author(s)
      Toshinori Fujie, Serge Ostrovidov, Samad Ahadian, S. Prakash Parthiban, Ali Khademhosseini, Hirokazu Kaji
    • Publisher
      World Scientific Publishing
    • Related Report
      2013 Annual Research Report
  • [Book] “Microfluidic systems for controlling stem cell microenvironments” In Microfluidic Cell Culture Systems, 2nd Edition2014

    • Author(s)
      Seila Selimovic, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini
    • Publisher
      Elsevier Publishing
    • Related Report
      2013 Annual Research Report
  • [Book] Muscle biology and structure for use in bioengineering muscle tissue devices2013

    • Author(s)
      Toshinori Fujie
    • Publisher
      World Scientific Publishing
    • Related Report
      2012 Annual Research Report
  • [Book] Elsevier Publishing2013

    • Author(s)
      Seila Selimovic
    • Publisher
      Microfluidic systems for controlling stem cell microenvironments
    • Related Report
      2012 Annual Research Report
  • [Book] MRS Symposium Proceesings Volume 1415, MEMS, BioMEMS and Bioelectronics – Materials and Devices, (pp. 1-221)2012

    • Author(s)
      Tim Albrecht, Maarten P. de Boer, Frank W. DelRio, Mehmet R. Dokmeci, Cristoph Eberl, Junji Fukuda, Hirokazu Kaji, Chris Keimel, Ali Khademhosseini
    • Publisher
      Cambridge University Press
    • Related Report
      2013 Final Research Report
  • [Book] "Impedance sensing of biological processes in mammalian cells" In Integrated Biomaterials for Biomedical Technology, M. Ramalingam, A. Tiwari, S. Ramakrishna, H. Kobayashi, Eds. (pp. 293-308)2012

    • Author(s)
      Lamya Ghenim, Hirokazu Kaji, Matsuhiko Nishizawa, Xavier Gidrol
    • Publisher
      Scrivener Publishing
    • Related Report
      2013 Final Research Report
  • [Book] MEMS, BioMEMS and Bioelectronics – Materials and Devices2012

    • Author(s)
      Tim Albrecht
    • Publisher
      Cambridge University Press
    • Related Report
      2012 Annual Research Report
  • [Book] Scrivener Publishing2012

    • Author(s)
      Lamya Ghenim
    • Publisher
      Impedance sensing of biological processes in mammalian cells
    • Related Report
      2012 Annual Research Report
  • [Book] Integrated Biomaterials : Materials in Medicine2012

    • Author(s)
      L.Ghenim, et al
    • Publisher
      VBRI press(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Microfluidic Cell Culture Systems, 2nd Edition2012

    • Author(s)
      S.Selimovic, et al
    • Publisher
      Elsevier Publishing(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] "Microscale biomaterials for tissue engineering" In Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends, J. A. Burdick, R. L. Mauck, Eds. (pp. 119-138)2011

    • Author(s)
      Ian Wheeldon, Javier Fernandez, Hojae Bae, Hirokazu Kaji, Ali Khademhosseini
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] Biomaterials for Tissue Engineering Applications : A Review of the Past and Future Trends2011

    • Author(s)
      I.Wheeldon, et al
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞担持パターン化ナノ薄膜2013

    • Inventor(s)
      梶 弘和, 藤枝俊宣, 森 好弘, 西澤松彦, 阿部俊明, 永井展裕
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-137253
    • Filing Date
      2013-06-28
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞担持パターン化ナノ薄膜2013

    • Inventor(s)
      梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
    • Industrial Property Rights Holder
      梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-137253
    • Filing Date
      2013-06-28
    • Related Report
      2013 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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