| Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Outline of Final Research Achievements |
A lot of multi-functional complex molecules are known in biologically active compounds. A seletive oxidation of the intended hydroxy groups in the presence of the other hydroxy groups is promising strategy for an efficient synthesis of such molecules. TEMPO-catalyzed reaction selectively oxidizes primary alcohols in the presence of secondary alcohols. Based on the reaction mechanism, we tried to design new catalysts having the different selectivity from TEMPO and develop new selective oxidations. As a result, we have developed DMN-AZADO as a highly effictive catalyst for a selective oxidation of primary alcohols, and also developed the chemoselective oxidation of 1,2-diols to alpha-hydroxy acids. During the development of a selective oxidation of 1,2-diols, we also found two types of one-pot oxidative cleavage of vicinal diols to the corresponding (di)carboxylic acids.
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