Elucidation of osteocyte regulation
| Project/Area Number |
23689006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIKAWA Keizo 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤)助教(常勤) (30516290)
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|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 骨細胞 / 骨芽細胞 / 転写因子 / iPSC / 胚葉体 / 分化 / コンディショナルノックアウト / 転写制御 / コンディショナルノックアウトマウス |
|---|
| Research Abstract |
The development of methods for differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cell (iPSCs) into functional cells have helped to analyze the mechanism in regulating cellular processes and to explore for cell-based assays for drug discovery. In this study, we developed methods for differentiation of ESCs and/or iPSCs into bone cells (osteoclast, osteoblast and osteocyte). In addition, we succeeded in identifying transcription factors involved in osteoblast and/or osteocyte differentiation. Our studies could provide important therapeutic targets for bone disease.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo2013
Author(s)
Kagawa Y, Matsumoto S, Kamioka Y, Mimori K, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M
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Journal Title
Related Report
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[Journal Article] MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development2011
Author(s)
Kamitani-Kawamoto A, Hamada M, Moriguchi T, Miyai M, Saji F, Hatamura I, Nishikawa K, Takayanagi H, Hitoshi S, Ikenaka K, Hosoya T, Hotta Y, Takahashi S, Kataoka K
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Journal Title
Journal Bone and Mineral Research
Volume: 24
Pages: 2463-72
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