Effects of carbon monoxide on bone metabolism.
Project/Area Number |
23689067
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
|
Research Institution | Keio University |
Principal Investigator |
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
Keywords | 骨代謝 / ガスバイオロジー / 骨・軟骨代謝 |
Research Abstract |
Carbon monoxide has been recognized as a gaseous mediator with a variety of physiological functions. However, its role in the control of skeletal function is unknown. Carbon monoxide can be physiologically generated by enzymes, heme oxygenase (HO). To define the physiological function of carbon monoxide in the skeletal tissue, we performed functional analysis of bone metabolism in osteoclast-specific HO knockout mice. The knockout mice showed ectopic bone formation. These results suggest that carbon monoxide is essential for normal bone remodeling.
|
Report
(4 results)
Research Products
(9 results)
-
-
[Journal Article] Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis2012
Author(s)
Hirose, Y., Saijou, E., Sugan,o Y., Takeshita, F., Nishimura, S., Nonaka, H., Chen, Y.R., Sekine, K., Kido, T., Nakamura, T., Kato, S., Kanke, T., Nakamura, K., Nagai, R., Ochiya, T., Miyajima, A.
-
Journal Title
Proc.Natl.Acad.Sci.USA
Volume: 109
Issue: 11
Pages: 4263-4268
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-