Physiological analysis of process specific synaptic tagging
| Project/Area Number |
23700449
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
ISHIKAWA Yasuyuki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (90346320)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経可塑性 / 記憶 / 学習 / 連合可塑性 / ニューロプシン / タギング / シナプス連合 / 連合記憶 / シナプス・タグ |
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| Research Abstract |
Activity-dependent synaptic plasticity is widely accepted to provide a cellular basis for learning and memory. Synaptic associativity could be involvedin activity-dependent synaptic plasticity, because it distinguishes between local mechanisms of synaptic tags and cell-wide mechanisms that are responsible for the synthesis of plasticity-related proteins. We report that a plasticity-related serine protease, neuropsin, is involved in the tag-setting process during long-term potentiation (LTP) at basal and apical dendritic inputs. Neuropsin is involved in synaptic associativity during LTP at apical dendritic inputs via integrin β1 and CaMKII signalling. Thus, neuropsin is a candidate molecule for LTP-specific tag-setting and could regulate the transformation of early to late LTP during synaptic associativity. These findings may provide the understanding of the regulation of synaptic associativity as complex information-processing systems.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] CMOS Image Sensor Integrated with Micro-LED and Multielectrode Arrays for the Patterned Photostimulation and Multichannel Recording of Neuronal Tissue2012
Author(s)
Arata Nakajima, Hiroshi Kimura, Yosmongkol Sawadsaringkarn, Yasuyo Maezawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuyuki Ishikawa, Sadao Shiosaka, and Jun Ohta
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Journal Title
Virtual Journal for Biomedical Optics
Volume: 7
Issue: 6
Pages: 6097-6108
DOI
Related Report
Peer Reviewed
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[Journal Article] Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice.2012
Author(s)
Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T.
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Journal Title
Mol Brain
Volume: 5
Issue: 1
Pages: 43-43
DOI
NAID
Related Report
Peer Reviewed
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