| Project/Area Number |
23700491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional basic brain science
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| Research Institution | Chubu University (2012-2013)
National Center for Geriatrics and Gerontology (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳イメージング / 動物PET / うつ病 / 加齢性精神疾患 / セロトニン / ドーパミン / PET |
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| Research Abstract |
In this study, we estimated an effectiveness of PET imaging for evaluating depression and we measured brain monoamine component, especially serotonin transporter. We used serotonin transpoter ligand 11C-DASB, abtained rat brain serotonin transporter image by some age group. Then, we suggested empression of serotonin transporter was differ in some age group, and the difference could distinguish by brain imaging. In addition, we compared with brain setoronin transporter image and amount of brain serotonin, transporter expression level in rats which received physical stress. From these results, we suggested that PET imaging would be effectual tool for brain serotonin component and estimating the condition of the depression.
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