Development of a minimally-invasive ECoGmeasurement employing smart metal and MEMS technologies

• Project/Area Number: 23700493
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Fusional brain recording science
• Research Institution: Shizuoka University
• Principal Investigator: YAMAKAWA Toshitaka 静岡大学, 工学部, 助教 (60510419)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脳活動記録(レコーディング) / 硬膜下電極 / 低侵襲 / フレキシブル回路技術 / ポリイミド / 形状記憶合金 / ＭＥＭＳ / 皮質脳波 / てんかん

Research Abstract

An electrode array which can be implanted with a minimally-invasive procedure and measures ECoG of a wider cortical region than the cranial window with a high spatial resolution have been developed employing MEMS fabrication technology. The safety and capability of the electrodes were confirmed in the phantom experiments which models subdural chronic implantation, and were evaluated with animal tests using monkeys.

Research Products

• [Journal Article] Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective. (2013)
  • Author(s): Yeting He
  • Journal Title: Brain Res Volume: 1497 Pages: 53-60
  • DOI: 10.1016/j.brainres.2012.11.041
  • Peer Reviewed
• [Journal Article] Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions (2011)
  • Author(s): Fujii M, et al
  • Journal Title: Epilepsia Volume: 53 Issue: 3 Pages: 489-493
  • DOI: 10.1111/j.1528-1167.2011.03388.x
  • Peer Reviewed
• [Journal Article] Subdural Electrocorticogram Measurement with a Minimally-Invasive Procedure using an SMA-Manipulated Microelectrode Array (2011)
  • Author(s): Toshitaka Yamakawa
  • Journal Title: Advanced Materials Research Volume: 222 Pages: 313-317
  • DOI: 10.4028/www.scientific.net/amr.222.313
  • Peer Reviewed
• [Presentation] A Minimally Invasive Brain-Machine Interface Employing Flexible Electronics (2012)
  • Author(s): Toshitaka Yamakawa, Toru Aoki, Takao Inoue, Masami Fujii, Michiyasu Suzuki, Takeshi Yamakawa
  • Organizer: The 14th Takayanagi Kenjiro Memorial Symposium - Toward Advanced Imagince Science Creation
  • Place of Presentation: 浜松市
• [Presentation] Flexible Electronics for Diagnostics and Treatment of Intractable Epilepsy (2012)
  • Author(s): Toshitaka Yamakawa, Toru Aoki, Takao Inoue, Masami Fujii, Michiyasu Suzuki, Takeshi Yamakawa
  • Organizer: 13th International Young Scientists Conference Optics and High Technology Material Science - SPO 2012
  • Place of Presentation: Kyiv(ウクライナ)
• [Presentation] Measurement Sensitivity of Deep Artery on Transabdominal Fetal Pulse Oximetry (2012)
  • Author(s): Tetsuya Iwano, Norbert Stuban, Toshitaka Yamakawa, Masatsugu Niwayama
  • Organizer: 34th Annual International IEEE EMBS Conference
  • Place of Presentation: San Diego(米国)
• [Presentation] Theoretical and Experimental Study for Determination of Characteristics of Bone Tissue Using Diffuse Reflectance (2012)
  • Author(s): Daisuke Wakabayashi, Kazuki Wakamori, Toshitaka Yamakawa, Masatsugu Niwayama
  • Organizer: 34th Annual International IEEE EMBS Conference
  • Place of Presentation: San Diego(米国)
• [Presentation] Design and Electrochemical Characterization of Polyimide Based Subdural Grid Electrodes for Minimally-Invasive Implantation (2012)
  • Author(s): Manato Kimura, Toru Aoki, Masatsugu Niwayama, Toshitaka Yamakawa
  • Organizer: 34th Annual International IEEE EMBS Conference
  • Place of Presentation: San Diego(米国)
• [Presentation] Development of a Focal Brain Cooling Device for the Treatment of Intractable Epilepsy (2012)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Tatsuji Tokiwa, Shuji Aou, Toru Aoki, Yuichi Maruta, Masami Fujii, Michiyasu Suzuki
  • Organizer: International Conference on Advanced Materials
  • Place of Presentation: Colombo(スリランカ)
• [Presentation] A Minimally Invasive Brain-Machine Interface Employing Flexible Electronics (2012)
  • Author(s): Toshitaka Yamakawa
  • Organizer: The 14th Takayanagi Kenjiro Memorial Symposium
  • Place of Presentation: 静岡大学(浜松市)
  • Invited
• [Presentation] Flexible Electronics for Diagnostics and Treatment of Intractable Epilepsy (2012)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 13th International Young Scientists Conference Optics and High Technology Material Science
  • Place of Presentation: キエフ国立大学(ウクライナ)
  • Invited
• [Presentation] Measurement Sensitivity of Deep Artery on Transabdominal Fetal Pulse Oximetry (2012)
  • Author(s): Tetsuya Iwano
  • Organizer: 34th Annual International IEEE EMBS Conference
  • Place of Presentation: Hilton San Diego Bayfront(米国)
• [Presentation] Theoretical and Experimental Study for Determination of Characteristics of Bone Tissue Using Diffuse Reflectance (2012)
  • Author(s): Daisuke Wakabayashi
  • Organizer: 34th Annual International IEEE EMBS Conference
  • Place of Presentation: Hilton San Diego Bayfront(米国)
• [Presentation] Design and Electrochemical Characterization of Polyimide Based Subdural Grid Electrodes for Minimally-Invasive Implantation (2012)
  • Author(s): Manato Kimura
  • Organizer: 34th Annual International IEEE EMBS Conference
  • Place of Presentation: Hilton San Diego Bayfront(米国)
• [Presentation] Development of a Focal Brain Cooling Device for the Treatment of Intractable Epilepsy (2012)
  • Author(s): Toshitaka Yamakawa
  • Organizer: International Conference on Advanced Materials, Science and Engineering 2012
  • Place of Presentation: Galle Face Hotel(スリランカ)
  • Invited
• [Presentation] Cool the Brain: A novel strategy to control the abnormal brain activity (2011)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Tatsuji Tokiwa, Shuji Aou, Toru Aoki, Yuichi Maruta, Masami Fujii, Michiyasu Suzuki
  • Organizer: 12th International Young Scientists Conference Optics and High Technology Material Science - SPO 2011
  • Place of Presentation: Kyiv(ウクライナ)
• [Presentation] Minimally-Invasive Epileptogenic Focus Detection Using the Subdural Electrodes Manipulated by the Shape-Memory-Alloy Thin Wire (2011)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Shuji Aou, Tatsuji Tokiwa, Masami Fujii, Michiyasu Suzuki
  • Organizer: 2011 International Conference on Systems, Man, Cybernetics
  • Place of Presentation: Anchorage(米国)
• [Presentation] Development of a focal cerebral cooling system for the treatment of intractable epilepsy: An experimental study in cats and non-human primates (2011)
  • Author(s): Takao Inoue, Masami Fujii, Yeting He, Yuichi Maruta, Hiroyuki Kida, Sadahiro Nomura, Michiyasu Suzuki, Toshitaka Yamakawa, Tatsuji Tokiwa, Takeshi Yamakawa, Kenichi Hirano, Masanori Niiyama, Hiromi Yamazaki
  • Organizer: 2011 International Conference on Systems, Man, Cybernetics
  • Place of Presentation: Anchorage(米国)
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling -A review of our past studies (2011)
  • Author(s): Masami Fujii, Takao Inoue, Yeting He, Yuichi Maruta, Hirochika Imoto, Hiroyasu Koizumi, Sadahiro Nomura, Tatsuji Tokiwa, Satoshi Ishizuka, Takeshi Yamakawa, Toshitaka Yamakawa
  • Organizer: 2011 International Conference on Systems, Man, Cybernetics
  • Place of Presentation: Anchorage(米国)
• [Presentation] Minimally-invasive ECoG recording using the novel subdural electrodes manipulated by a shape memory alloy guidewire (2011)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Shuji Aou, Satoru Ishizuka, Masami Fujii, Michiyasu Suzuki
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome(イタリア)
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling (2011)
  • Author(s): Masami Fujii, Takao Inoue, Y. He, H. Imoto, N. Tanaka, T. Oku, Yuichi Maruta, H. Koizumi, S. Nomura, Y. Owada, T. Saito, Toshitaka Yamakawa, T. Tokiwa, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome(イタリア)
• [Presentation] Energy Discriminated X-ray CT using High Count Rate Photon (2011)
  • Author(s): Toru Aoki, Akifumi Koike, Takaharu Okunoyama, Hisashi Morii, Shailendra Singh, Manato Kimura, Toshitaka Yamakawa, Hidenori Mimura
  • Place of Presentation: San Diego(米国)
• [Presentation] Carrier Transportation Properties in M-p-n and Schottky CdTe Diode (2011)
  • Author(s): Manato Kimura, Akifumi Koike, Takaharu Okunoyama, Hisashi Morii, Shailendra Singh, Toshitaka Yamakawa, Hidenori Mimura, Toru Aoki
  • Organizer: 2011 SPIE Optics + Photonics
  • Place of Presentation: San Diego(米国)
• [Presentation] A Low-Cost Long-Life R-R Interval Telemeter with Automatic Gain Control for Various ECG Amplitudes (2011)
  • Author(s): Toshitaka Yamakawa, Genki Matsumoto, Toru Aoki
  • Organizer: Inter-Academia 2011
  • Place of Presentation: Sucevita(ルーマニア)
• [Presentation] Cool the Brain: A novel strategy to control the abnormal brain activity (2011)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 12th International Young Scientists Conference Optics and High Technology Material Science(招待講演)
  • Place of Presentation: キエフ国立大学(ウクライナ)
• [Presentation] Minimally-Invasive Epileptogenic Focus Detection Using the Subdural Electrodes Manipulated by the Shape-Memory-Alloy Thin Wire (2011)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 2011 International Conference on Systems, Man, Cybernetics
  • Place of Presentation: ヒルトン・アンカレッジ(米国)
• [Presentation] Minimally-Invasive ECoG Recording Using the Novel Subdural Electrodes Manipulated by a Shape Memory Alloy Guidewire (2011)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: マリオット・ローマパークホテル(イタリア)
• [Remarks]
  • URL: http://www.ipc.shizuoka.ac.jp/ttyamak/