| Project/Area Number |
23700513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Kumamoto University |
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Principal Investigator |
SATO Yoshinori 熊本大学, エイズ学研究センター, COE リサーチ・アソシエイト (90455402)
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| Research Collaborator |
NAGATA Sayaka 熊本大学, エイズ学研究センター, 技術補佐員
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ヒト化マウス / HIV -1 感染症 / ヒト T 細胞 / HIV-1 / T細胞 |
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| Research Abstract |
A small animal model for the analysis of HIV -1 infection has notbeen established yet. T o establish the animal model, we generated new humanized miceand investigated the responses of human T cells against HIV -1 in the mice. HIV -1 wasdetected in plasma of the mice after HIV -1 infection and the number of CD4 T cells in themice decreased. Also, effector CD8 T cells which are important for the elimination ofHIV -1-infected cells were induced in the mice after HIV -1 infection. These results indicatethat a humanized mouse model will be available for the analysis of HIV -1 infection
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