• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of increased tissue oxygen tension on dermal aging

Research Project

Project/Area Number 23700827
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionThe University of Tokyo

Principal Investigator

KAWADA Shigeo  東京大学, 大学院・総合文化研究科, 特任研究員 (20376601)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生理学 / 老化 / ストレス / シグナル伝達 / 生体機能利用 / 皮膚老化 / 組織酸素分圧 / 抗老化 / 光老化 / 紫外線 / 皮膚 / 血管増殖
Research Abstract

The aim of this study was to investigate whether increased dermal oxygen tension attenuates ultraviolet (UV)-B-induced dermal angiogenesis and wrinkle formation.In experiment 1, the backs of the mice were exposed to UVB three times per week for a5-wk. To increase dermal oxygen tension, the mice were exposed to hyperoxia (90% oxygen) for 2 h immediately after each UVB irradiation. This experiment cleared that such acute UVB exposure results in wrinkle formation associated with increased cutaneousangiogenesis. However, hyperoxic exposure immediately after UVB exposure attenuates these phenomena.In experiment 2, we investigated the effects of hyperoxia on dermal aging induced by higher doses and longer periods of UVB irradiation. The backs of the mice were exposed to UVB three times per week for a 10-wk. Hyperoxic conditions could suppress increases in hypoxia-inducible factor (HIF)-1α levels, a key molecule for angiogenesis. However, UVB-induced wrinkle formation and angiogenesis were not attenuated. Activities of matrix metalloproteinases (MMP)-2 and MMP-9, which are key molecules in wrinkle formation, increased with higher-dose and longer-term UVB irradiation regardless of exposure to hyperoxic conditions. In experiment 1, MMP-2 and MMP-9 activities did not increase. These results suggest that suppression of increases in HIF-1α levels alone is insufficient to suppress wrinkle formation caused by higher doses and longer periods of UVB irradiation. Moreover, MMP-2 and MMP-9 might not play a critical role in either wrinkle formation or angiogenesis during the early stage of acute UVB-induced wrinkle formation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Mechanisms underlying ultraviolet radiation-induced dermal aging.2013

    • Author(s)
      Shigeo KAWADA, Satoshi NAKADA, YuheiMAKANAE.
    • Journal Title

      The Journal of PhysicalFitness and Sports Medicine

      Volume: 2(2) Pages: 225-228

    • NAID

      10031159041

    • URL

      http://www.jspfsm.umin.ne.jp/journal/index.htm

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying ultraviolet radiation-induced dermal aging2013

    • Author(s)
      Shigeo KAWADA
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 印刷中

    • NAID

      10031159041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of UVB-induced HIF-1 α up-regulation by hyperoxia dose not prevent wrinkle formation associated with increased MMPs activity in mouse skin.2011

    • Author(s)
      Shigeo KAWADA and Naokata ISHII.
    • Journal Title

      Biomedical Research

      Volume: 32(6) Pages: 363-372

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of UVB-induced HIF-1.ALPHA. up-regulation by hyperoxia does not prevent wrinkle formation associated with increased MMPs activity in mouse skin2011

    • Author(s)
      川田茂雄 石井直方
    • Journal Title

      Biomedical Research

      Volume: 32 Issue: 6 Pages: 363-372

    • DOI

      10.2220/biomedres.32.363

    • NAID

      130004470789

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] MMP-2とMMP-9活性の増大を伴う皮膚老化に対する高酸素暴露の効果2011

    • Author(s)
      川田茂雄 石井直方
    • Organizer
      第66回 日本体力医学会
    • Place of Presentation
      山口県
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi