Japanese rice wine (Sake)-derived components has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis in mice

• Project/Area Number: 23700913
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kyoto Prefectural University
• Principal Investigator: WADA Sayori 京都府立大学, 大学院・生命環境科学研究科, 講師 (60420709)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 特殊栄養食品 / 炎症性腸疾患 / 機能性ペプチド / 発酵食品 / 腸内細菌 / 抗炎症 / ペプチド / 日本酒 / 食品因子 / 生体内活性 / Autofocusing

Research Abstract

The number of Inflammatory bowel disease (IBD) patients is increasing and the change in eating habit is one of the factor of these increasing. It has been reported that several fermented foods have improving effect of IBD. We determined the anti-inflammatory effect of Japanese rice wine-derived peptide on dextran sulfate sodium (DSS)-induced acute colitis in mice. Some peptide derived from Japanese rice wine showed the colitis improving effect at the concentration of few mg/kg/day. This result indicates that Japanese sake-derived components have a potent of therapeutic agent on IBD.

Research Products

• [Journal Article] Colorectal cancer preventive effects of food components (2012)
  • Author(s): Wada S
  • Journal Title: In Georgakilas A.G, (ed.) Cancer Prevention - From Mechaisms to Translational Benefits Pages: 205-230
  • Peer Reviewed
• [Journal Article] Cancer preventive effects of vitamin E (2012)
  • Author(s): Wada S
  • Journal Title: Curr Pharm Biotechnol Volume: 1 Pages: 156-164
  • Peer Reviewed
• [Journal Article] Cancer preventive effects of vitamin E. (2012)
  • Author(s): Wada S.
  • Journal Title: Curr Pharm Biotechnol Volume: 13 Pages: 156-64
  • Peer Reviewed
• [Journal Article] An evaluation of protein intake for metabolic demands and the quality of dietary protein in rats using an indicator amino acid oxidation method. (2011)
  • Author(s): Ogawa A, Naruse Y, Shigemura Y, Kobayashi Y, Suzuki I, Wada S, Hayamizu K, Kuwahata M, Kido Y.
  • Journal Title: J Nutr Sci Vitaminol Volume: 57 Pages: 418-25
  • NAID: 130002103052
  • Peer Reviewed
• [Journal Article] Lifestyle and psychological factors related to irritable bowel syndrome in nursing and medical school students. (2011)
  • Author(s): Okami Y, Kato T, Nin G, Harada K, Aoi W, Wada S, Higashi A, Okuyama Y, Takakuwa S, Ichikawa H, Kanazawa M, Fukudo S.
  • Journal Title: J Gastroenterol Volume: 46 Pages: 1403-10
  • NAID: 10030295293
  • Peer Reviewed
• [Presentation] Japanese rice wine (Sake)-derived components has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis in mice (2012)
  • Author(s): Wada S, Bou Y, Fukunaga S, Wada E,Kiyono T, Takagi T, Sato K, Naito Y, Yoshikawa T
  • Organizer: International Conference on Food Factor
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2012-12-05
• [Presentation] Absorption of food-derived anti-inflammatory peptide, pGlu-Leu, from gastric intestinal tracts (2012)
  • Author(s): Kiyono T, Bou Y, Fukunaga S, Wada S, Takagi T, Naito Y, Yoshikawa Y, Park E.Y., Nakamura Y, Sato K
  • Organizer: International Conference on Food Factor
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2012-12-04
• [Presentation] 抗炎症性ペプチド pGlu-Leu のデキストラン硫酸ナトリウム誘発性大腸炎に対する効果と体内取込 (2012)
  • Author(s): 清野珠美,和田小依里,高木智久,内藤裕二, 朴恩榮,中村考志,佐藤健司
  • Organizer: 日本食品科学工学会 第59回大会
  • Place of Presentation: 札幌, 北海道
  • Year and Date: 2012-08-29
• [Presentation] Japanese rice wine (Sake)-derived components has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis in mice (2012)
  • Author(s): Wada S, Bou Y, Fukunaga S, Wada E, Kiyono T, Takagi T, Sato K, Naito Y, Yoshikawa T
  • Organizer: The International Society for Nutraceuticals and Functional Foods
  • Place of Presentation: Hawaii, USA
• [Presentation] Absorption of food-derived anti-inflammatory peptide, pGlu-Leu, from gastric intestinal tracts (2012)
  • Author(s): Kiyono T, Bou Y, Fukunaga S, Wada S, Takagi T, Naito Y, Yoshikawa Y, Park E.Y., Nakamura Y, Sato K
  • Organizer: The International Society for Nutraceuticals and Functional Foods
  • Place of Presentation: Hawaii, USA
• [Presentation] 抗炎症性ペプチドpGlu-Leuのデキストラン硫酸ナトリウム誘発性大腸炎に対する効果と体内取込 (2012)
  • Author(s): 清野珠美，和田小依里，高木智久，内藤裕二， 朴恩榮，中村考志，佐藤健司
  • Organizer: 日本食品科学工学会 第59 回大会
  • Place of Presentation: 札幌、北海道
• [Presentation] Japanese rice wine (Sake)-derived components has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis (2011)
  • Author(s): Wada S, Wada E, Ohta R, Kiyono T, Horie R, Takagi T, Sato K, Naito Y, Yoshikawa T
  • Organizer: International Conference on Food Factor
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2011-11-21
• [Presentation] pyroGlu-Leu has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis (2011)
  • Author(s): Wada S, Ohta R, Kiyono T, Horie R, Takagi T, Sato K, Naito Y, Yoshikawa T
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2011-11-16
• [Presentation] Japanese rice wine (sake)-derived components have anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis (2011)
  • Author(s): Wada S, Ohta R, Kiyono T, Horie R, Takagi T, Sato K, Naito Y, Yoshikawa T
  • Organizer: 10th world congress on inflammation
  • Place of Presentation: Paris, France, Abstract
  • Year and Date: 2011-06-26
• [Presentation] Japanese rice wine (sake)-derived components have anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis. (2011)
  • Author(s): Wada S, Ohta R, Kiyono T, Horie R, Takagi T, Sato K, Naito Y, Yoshikawa T.
  • Organizer: 10th World Congress on Inflammation
  • Place of Presentation: パリ フランス
• [Presentation] pyroGlu-Leu has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis. (2011)
  • Author(s): Wada S, Ohta R, Kiyono T, Horie R, Takagi T, Sato K, Naito Y, Yoshikawa T.
  • Organizer: International Conference and Exhibition on Nutraceuticals and Functional Foods(招待講演)
  • Place of Presentation: 札幌
• [Presentation] Japanese rice wine (Sake)-derived components has anti-inflammatory effect on dextran sulfate sodium (DSS)-induced acute colitis. (2011)
  • Author(s): Wada S, Wada E, Ohta R, Kiyono T, Horie R, Takagi T, Sato K, Naito Y, Yoshikawa T.
  • Organizer: International Conference on Food Factor
  • Place of Presentation: 台北 台湾
• [Book] Chapter 7 Mechanism of Delta-Tocotrienol on Colorectal Cancer (2012)
  • Author(s): Wada S, Naito Y
  • Publisher: Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition
• [Book] Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition (2012)
  • Author(s): Wada S, Naito Y; Tan B, Watson R.R, Preedy V.R, (eds.)
  • Total Pages: 400
  • Publisher: CRC Press