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Exploration of bioactive natural products which induce selective apoptosis in tumor cells from Kampo formulas

Research Project

Project/Area Number 23710249
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Living organism molecular science
Research InstitutionChiba University

Principal Investigator

TOUME Kazufumi  千葉大学, 大学院・薬学研究院, 助教 (80563981)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords天然物化学 / TRAIL / アポトーシス / 生物活性天然物 / がん / 生薬 / DR5
Research Abstract

In this study, we examined extracts of natural resources including Kampo formulas for bioactive natural products which induce selective apoptosis in tumor cells. As a result of this screening study we have isolated several active compounds. The mode of action for isolated compounds was also investigated.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (60 results)

All 2014 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (36 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] β-sitosterol and flavonoids isolated from Bauhinia malabarica found in a screening program for Wnt signal inhibitory activity2014

    • Author(s)
      Park, H.-Y.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M
    • Journal Title

      J. Nat. Med

      Volume: (in press) Issue: 1 Pages: 242-245

    • DOI

      10.1007/s11418-013-0762-3

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eudesmane-type Sesquiterpenoid and Guaianolides from Kandelia candel in a Screening Program for Compounds to Overcome TRAIL-resistance2012

    • Author(s)
      Minakawa, T.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M
    • Journal Title

      J. Nat. Prod

      Volume: 75 Pages: 1431-1435

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Griseoviridin and cyclic hydroxamates found in a screening program for Wnt signal inhibitor2012

    • Author(s)
      Tamai, Y.; Toume, K.; Arai, M. A.; Ishibashi, M
    • Journal Title

      Heterocycles

      Volume: 86 Pages: 1517-1524

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cycloartane triterpenes and ingol diterpenes isolated from Euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity2012

    • Author(s)
      Toume, K.; Nakazawa, T.; Tahmina, H.; Ohtsuki, T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
    • Journal Title

      Planta medica

      Volume: 78 Pages: 1370-1377

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Katorazone, a novel yellow pigment with2-azaquinone-phenylhydrazone structure produced by Streptomyces sp. IFM 113072012

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Arai, M. A.; Masu, H.; Ishibashi, M.
    • Journal Title

      Tetrahedron Lett

      Volume: 53 Pages: 3346-3348

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yoropyrazone, a new naphthopyridazone alkaloid isolated from Streptomyces sp. IFM11307 and evaluation of its TRAILresistance-overcoming activity2012

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Ishibashi, M.
    • Journal Title

      J. Antibiot

      Volume: 65 Pages: 245-248

    • NAID

      10030641514

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica2012

    • Author(s)
      Yamaguchi, T.; Toume, K.; Arai, M. A.; Ahmed, F.; Sadhu, S. K.; Ishibashi, M.
    • Journal Title

      Nat. Prod. Commun

      Volume: 7 Pages: 475-477

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonactin and related compounds found in a screening program for Wnt signal inhibitory activity2012

    • Author(s)
      Tamai, Y.; Toume, K.; Arai, M. A.; Hayashida, A.; Kato, H.; Shizuri, Y.; Tsukamoto, S.; Ishibashi, M.
    • Journal Title

      Heterocycles

      Volume: 84 Pages: 1245-1250

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL-resistance2012

    • Author(s)
      Minakawa, T.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.
    • Journal Title

      J. Nat. Prod

      Volume: 75 Issue: 8 Pages: 1431-1435

    • DOI

      10.1021/np300179c

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Katorazone, a novelyellow pigment with2-azaquinone-phenylhydrazone structure produced by Streptomyces sp. IFM 112992012

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Arai, M. A.; Masu, H.; Ishibashi, M.
    • Journal Title

      Tetrahedron Lett

      Volume: 53 Issue: 26 Pages: 3346-3348

    • DOI

      10.1016/j.tetlet.2012.04.073

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yoropyrazone, a new naphthopyridazone alkaloid isolated from Streptomyces sp. IFM11307 and evaluation of its TRAILresistance-overcoming activity2012

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Ishibashi, M.
    • Journal Title

      J. Antibiot

      Volume: 65 Issue: 5 Pages: 245-248

    • DOI

      10.1038/ja.2012.11

    • NAID

      10030641514

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New pyranonaphthoquinones and phenazine alkaloid isolated from Streptomyces sp. IFM 11307 with TRAIL resistance-overcoming activity2011

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Ishibashi, M.
    • Journal Title

      J. Antibiot

      Volume: 64 Pages: 729-734

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Izumiphenazine D, new phenazoquinoline N-oxide from Streptomyces sp. IFM 112042011

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Ishibashi, M.
    • Journal Title

      Chem. Pharm. Bull

      Volume: 59 Pages: 508-510

    • NAID

      130000648975

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity2011

    • Author(s)
      Toume, K.; Nakazawa, T.; Ohtsuki, T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
    • Journal Title

      J. Nat. Prod

      Volume: 74 Pages: 249-255

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and structure elucidation of izuminosides A-C: a rare phenazine glycosides from Streptomyces sp. IFM112602011

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Ishibashi, M.
    • Journal Title

      J. Antibiot

      Volume: 64 Pages: 271-275

    • NAID

      10030638410

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tubiferic acid, a new 9,10-secocycloartane triterpenoid acid isolated from the myxomycete Tubulifera arachnoidea2011

    • Author(s)
      Ippongi, Y.; Ohtsuki, T.; Toume, K.; Arai, M.A.; Yamamoto, Y.; Ishibashi, M.
    • Journal Title

      Chem. Pharm. Bull

      Volume: 59 Pages: 279-281

    • NAID

      130000405528

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2-Methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling2011

    • Author(s)
      Mori, N.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
    • Journal Title

      J. Nat. Med

      Volume: 65 Pages: 234-236

    • NAID

      10029460988

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis2011

    • Author(s)
      Ahmed, F.; Toume, K.; Ohtsuki, T.; Rahman, M.; Sadhu, S. K.; Ishibashi, M.
    • Journal Title

      Phytotherapy Research

      Volume: 25 Pages: 147-150

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] New pyranonaphthoquinones and phenazine alkaloid isolated from Streptomyces sp. IFM11307 with TRAIL resistance-overcoming activity2011

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Ishibashi, M.
    • Journal Title

      J. Antibiot

      Volume: 64 Issue: 11 Pages: 729-734

    • DOI

      10.1038/ja.2011.85

    • NAID

      10030640679

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cycloartane Triterpenes Isolated from Combretum quadrangulare in a Screening Program for Death-Receptor Expression Enhancing Activity2011

    • Author(s)
      Toume, K.; Nakazawa,T.; Ohtsuki, T.; Arai, M.A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
    • Journal Title

      J.Nat.Prod.

      Volume: 74 Issue: 2 Pages: 249-255

    • DOI

      10.1021/np100784t

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation and structure elucidation of izuminosides A-C: a rare phenazine glycosides from Streptomyces sp. IFM 112602011

    • Author(s)
      Abdelfattah, M. S.; Toume, K.; Ishibashi, M.
    • Journal Title

      J. Antibiot.

      Volume: 64 Pages: 271-275

    • NAID

      10030638410

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Calotropis gigantea からの Wnt シグナル阻害作用をもつカ ルデノリド2012

    • Author(s)
      朴賢英, 當銘 一文 ,荒井緑,S. K. Sadhu, F. Ahmed,石橋正己
    • Organizer
      第19回天然薬物の開発と応用シンポジウム講演要旨集
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Xylocarpus granatum からの Wnt シグナル阻害作用 をもつ天然化化合物の探索2012

    • Author(s)
      神谷謙太朗, 當 銘 一 文 ,荒井緑,S. K.Sadhu,F. Ahmed,石橋正己
    • Organizer
      第19回天 然薬物の開発と応用シンポジウム講演 要旨集 85-87
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] TRAIL耐性克服作用をもつ天然物の探索 : Artocarpus champeden のプレニルフラボン成分2012

    • Author(s)
      皆川朋皓, 當 銘一文 ,荒井緑,小谷野喬, T. Kowithayakorn,石橋正己
    • Organizer
      第56回香料・テルペンおよび精油化学に関する討論会講演要旨集
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 千葉産放線菌由来新規生物活性芳香族複素環化合物2012

    • Author(s)
      M.Abdelfattah,當銘一文,荒井緑,石橋正己
    • Organizer
      第54回天然有機化合物討論会講演要旨集
    • Place of Presentation
      東京
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞 毒性を有する放線菌由来マクロラクタム2012

    • Author(s)
      塚原健太郎,當銘一文,石橋正己
    • Organizer
      日本生薬学会第59年会講演要旨集
    • Place of Presentation
      千葉
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Xylocarpus granatum 由来の Wnt シグナル阻害作用をもつ新規リモノイド2012

    • Author(s)
      神谷謙太朗, 當銘一文,荒井緑,S. K.Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第59年会講演要旨集
    • Place of Presentation
      千葉
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Search for bioactive natural products from Curcuma comosa with Wnt signal inhibitory activity2012

    • Author(s)
      R. G. Fuentes,當銘一文,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本生薬学会第59年会講演要旨集
    • Place of Presentation
      千葉
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Calotropis gigantea 由来の Wnt シグナル阻害するカルデノライド2012

    • Author(s)
      朴賢英, 當銘一文 ,荒井緑,S. K. Sadhu, F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第59年会講演要旨集
    • Place of Presentation
      千葉
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Artocarpus communis 等からのTRAIL 耐性克服作用を有する天然物の探索2012

    • Author(s)
      土生理, 當 銘 一文 ,荒井緑,小谷野喬, T. Kowithayakorn,S. K. Sadhu,F. Ahmed, 石橋正己
    • Organizer
      日本生薬学会第59年会講演要旨集
    • Place of Presentation
      千葉
    • Year and Date
      2012-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] "疾患および再生シグナルに作用する天然物の探索", 新学術領域研究「天然物ケミカルバイオロジー~分子標的と活性制御~」2012

    • Author(s)
      石橋正己,荒井緑,當銘一文
    • Organizer
      第2回公開シンポジウム講演要旨集17-18
    • Place of Presentation
      東京
    • Year and Date
      2012-06-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Wnt シグナル阻害作用をもつ Xylocarpus granatum 由 来の新規リモノイド2012

    • Author(s)
      神谷謙太朗,當銘一文,S. K. Sadhu,F.Ahmed,荒井緑,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Streptomyces sp. IFM11307ら単離した TRAIL 耐性克服作用をもつグリセウシン類エナンチオマー2012

    • Author(s)
      M. Abdelfattah, 當銘一文 ,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Artocarpus champeden からの TRAIL 耐性克服作用を 有する天然物の探索2012

    • Author(s)
      皆川朋皓, 當銘一文 ,荒井緑,小谷野喬, T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Artocarpus communis からの TRAIL 耐性克服作用を有する天然物の探索2012

    • Author(s)
      土生理,當銘一文,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Derris indica等からのデス受容体誘導作用をもつ天然物の探索2012

    • Author(s)
      T. Hoque, 當銘一文 ,荒井緑,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 海洋 放線菌から単離した TRAIL 耐性克服作 用をもつクロモマイシン類2012

    • Author(s)
      塚原健太郎,當銘一文,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Calotropis gigantea からの Wnt シグナル阻害作用をもつ天然物 の 探 索2012

    • Author(s)
      朴賢英,當銘一文,荒井緑,S. K. Sadhu, F. Ahmed,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardenolides Isolated from Calotropis gigantea with WntSignaling Inhibitory Activity2012

    • Author(s)
      朴賢英, 當銘一文 ,荒井緑,S. K. Sadhu, F. Ahmed ,石橋正己
    • Organizer
      The 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Streptomyces sp. IFM11307から単離したTRAIL耐性克服作用をもつグリセウシン類エナンチオマー2012

    • Author(s)
      M. Abdelfattah,當銘一文,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Artocarpus champedenからのTRAIL耐性克服作用を有する天然物の探索2012

    • Author(s)
      皆川朋皓,當銘一文,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Artocarpus communisからのTRAIL耐性克服作用を有する天然物の探索2012

    • Author(s)
      土生理,當銘一文,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] ピロン環およびビスインドール骨格を含む変形菌の化学成分2011

    • Author(s)
      石橋正己,新谷彰教, 當銘一文 ,荒井緑
    • Organizer
      第41回複素環化学討論会講演要旨集
    • Place of Presentation
      熊本
    • Year and Date
      2011-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Kandelia candel からの TRAIL 耐性克服作用を有する天 然物の探索2011

    • Author(s)
      皆川朋皓, 當銘一文 ,荒井緑,S. K. Sadhu, F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第58年会講演要旨集
    • Place of Presentation
      東京
    • Year and Date
      2011-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Xylocarpus granatum からのWntシグナル阻害作用をもつ天然物の探索2011

    • Author(s)
      神谷謙太朗,森直美, 當銘一文 ,荒井緑, S. K. Sadhu , F. Ahmed , 石橋 正己
    • Organizer
      日本生薬学会第58年会講演要旨集
    • Place of Presentation
      東京
    • Year and Date
      2011-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Search for bioactive constituents from Derris indica with DR5 promoter activity2011

    • Author(s)
      Hoque Tahmina, 當銘一文 ,荒井緑,S. K.Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第58年会講演要旨集
    • Place of Presentation
      東京
    • Year and Date
      2011-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Calotropis gigantea からのWntシグナル阻害作用をもつ天 然物の探索2011

    • Author(s)
      朴賢英, 當銘一文 ,荒井緑,S. K. Sadhu, F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第58年会講演要旨集
    • Place of Presentation
      東京
    • Year and Date
      2011-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 放線菌からの Wnt シグナル阻害作用をもつ天然物の探索2011

    • Author(s)
      玉井佑弥, 當銘一文 ,荒井緑,石橋正己
    • Organizer
      日本生薬学会第58年会講演要旨集
    • Place of Presentation
      東京
    • Year and Date
      2011-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] ウィントシグナルを制御する天然物の探索2011

    • Author(s)
      當銘一文,荒井緑,石橋正己
    • Organizer
      日本生薬学会第58年会講演要旨集
    • Place of Presentation
      東京
    • Year and Date
      2011-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Kandelia candelからのTRAIL 耐性克服作用を有する天然物の探索2011

    • Author(s)
      皆川朋皓,當銘一文,荒井緑,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第58年会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Search for bioactive constituents from Derris indica with DR5 promoter activity2011

    • Author(s)
      Hoque Tahmina,當銘一文,荒井緑,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第58年会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] ウィントシグナルを制御する天然物の探索2011

    • Author(s)
      當銘一文,荒井緑,石橋正己
    • Organizer
      日本生薬学会第58年会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Saussurea hypoleucaからのTRAIL耐性克服作用を有する天然物の探索

    • Author(s)
      土生理,當銘一文,荒井緑,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Calotropis giganteaからのWntシグナル阻害作用をもつカルデノリド

    • Author(s)
      朴賢英,當銘一文,荒井緑,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      第19回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] TRAIL耐性克服作用をもつ天然物の探索:Artocarpus champedenのプレニルフラボン成分

    • Author(s)
      皆川朋皓,當銘一文,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      第56回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 千葉産放線菌由来新規生物活性芳香族複素環化合物

    • Author(s)
      M. Abdelfattah,當銘一文,荒井緑,石橋正己
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Xylocarpus granatum由来のWntシグナル阻害作用をもつ新規リモノイド

    • Author(s)
      神谷謙太朗,當銘一文,荒井緑,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第59年会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Remarks] 活性構造化学研究室

    • URL

      http://www.p.chiba-u.ac.jp/lab/kouzou/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.chiba-u.ac.jp/lab/kouzou/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] エルモニン2013

    • Inventor(s)
      石橋正己・塚原健太郎・當銘一文
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2013-068062
    • Filing Date
      2013-03-28
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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