Study of compounds that influence facultative symbiosis between coral and seagrass

• Project/Area Number: 23710258
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Living organism molecular science
• Research Institution: University of the Ryukyus
• Principal Investigator: TERUYA TOSHIAKI 琉球大学, 教育学部, 准教授 (90375428)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: リュウキュウスガモ / エダコモンサンゴ / 混合群落 / コユビミドリイシ / エダコモンサンゴ幼生 / カフェ酸 / 褐虫藻 / 相利関係

Research Abstract

In this study, we examined compounds that influence facultative symbiosis between coral Montipora digitata and seagrass Thalassa hemprichii, which can be seen near Bise on the west coast of Okinawa Island. Acropora sp.1 was used as a control. We evaluated the influence of a crude extract of seagrass T. hemprichii against coral larvae. The seagrass T. hemprichii was directly harvested in Okinawa Prefecture. A crude organic extract of this material was subjected to bioassay-guided (toxicity against coral larvae) fractionation by solvent partition, ODS-HPLC, to yield caffeic acid. Morphological changes of lavae of Acropora sp.1 were induced by exposure to 0.0018 mg/ml-0.18 mg/ml caffeic acid. On the other hand, no morphological changes of lavae of M. digitata were induced at same concentration.

Research Products

• [Journal Article] Fargesin, a component of Flos Magnoliae, stimulates glucose uptake in L6 myotubes (2013)
  • Author(s): Choi, S-S.; Cha, B-Y.; Choi, B-K.; Lee, Y-S.; Yonezawa, T.; Teruya, T.; Nagai, K.; Woo, J-T.
  • Journal Title: Journal of Natural Medicines Volume: 67 Pages: 320-326
  • Peer Reviewed
• [Journal Article] Bisebromoamide, an extract from Lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells (2013)
  • Author(s): Suzuki, K.; Mizuno, R.; Suenaga, K.; Teruya, T.; Tanaka, N.; Kosaka, T.; Oya, M.
  • Journal Title: Cancer Medicine Volume: 2 Pages: 32-39
  • Peer Reviewed
• [Journal Article] Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivatives (2013)
  • Author(s): Ohno, O.; Morita, M.; Kitamura, K.; Teruya, T.; Yoneda, K.; Kita, M.; Kigoshi, H.; Suenaga, K.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 23 Pages: 1467-1471
  • Peer Reviewed
• [Journal Article] Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice (2013)
  • Author(s): Lee, Y-S.; Cha, B-Y.; Choi, S-S.; Choi, B-K.; Yonezawa, T.; Teruya, T.; Nagai, K.; Woo, J-T.
  • Journal Title: Journal of Nutritional Biochemistry Volume: 24 Pages: 156-162
  • Peer Reviewed
• [Journal Article] Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes (2012)
  • Author(s): Choi, S-S.; Cha, B-Y.; Lee, Y.-S.; Yonezawa, T.; Teruya, T.; Nagai, K.; Woo, J-T.
  • Journal Title: Bio Factors Volume: 38 Pages: 372-377
  • Peer Reviewed
• [Journal Article] Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice (2012)
  • Author(s): Lee, Y-S.; Cha, B-Y.; Choi, S-S.; Harada, Y.; Choi, B-K.; Yonezawa, T.; Teruya, T.; Nagai, K.; Woo, J-T.
  • Journal Title: Bio Factors Volume: 38 Pages: 300-308
  • Peer Reviewed
• [Journal Article] Effects of veraguensin and galgravin on osteoclast differentiation and function (2012)
  • Author(s): Asai, M.; Lee, J-W.; Itakura, Y.; Choi, B-K.; Yonezawa, T.; Teruya, T.; Cha, B-Y.; Ohnishi, M.; Yamaguchi, A.; Woo, J-T.
  • Journal Title: Cytotechnology Volume: 64 Pages: 315-322
  • Peer Reviewed
• [Journal Article] Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides (2012)
  • Author(s): Morita, M.; Ohno, O.; Teruya, T.; Yamori, T.; Inuzuka, T.; Suenaga, K.
  • Journal Title: Tetrahedron Volume: 68 Pages: 5984-5990
  • Peer Reviewed
• [Journal Article] Biselyngbyaside, isolated from marine cyanobacteria, inhibits osteoclastogenesis and induces apoptosis in mature osteoclasts (2012)
  • Author(s): Yonezawa, T.; Mase, N.; Sasaki, H.; Teruya, T.; Hasegawa, S-. Cha, B-Y. Yagasaki, K. Suenaga, K. Nagai, K. Woo, J-T.
  • Journal Title: Journal of Cellular Biochemistry Volume: 113 Pages: 440-448
  • Peer Reviewed
• [Journal Article] Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice (2012)
  • Author(s): Young-Sil Lee, Byung-Yoon Cha, Sun-Sil Choi, Bong-Keun Choi, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Je-Tae Woo.
  • Journal Title: Journal of Nutritional Biochemistry Volume: 24 Issue: 1 Pages: 156-162
  • DOI: 10.1016/j.jnutbio.2012.03.014
  • Peer Reviewed
• [Journal Article] Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice (2012)
  • Author(s): Young-Sil Lee, Byung-Yoon Cha, Sun-Sil Choi, Yumiko Harada, Bong-Keun Choi, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Je-Tae Woo.
  • Journal Title: BioFactors Volume: 38 Issue: 4 Pages: 1872-8081
  • DOI: 10.1002/biof.1022
  • Peer Reviewed
• [Journal Article] Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes (2012)
  • Author(s): Sun-Sil Choi, Byung-Yoon Cha, Young-Sil Lee, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Je-Tae Woo.
  • Journal Title: BioFactors Volume: 38 Issue: 5 Pages: 372-377
  • DOI: 10.1002/biof.1029
• [Journal Article] Allelopathy of red pine : Isolation and identification of an allelopathic substance in red pine needles (2011)
  • Author(s): Kato-Noguchi, H.; Fushimi, Y.; Tanaka, Y.; Teruya, T.; Suenaga, K.
  • Journal Title: Plant Growth Regulation Volume: 65 Pages: 299-304
  • Peer Reviewed
• [Journal Article] Two potent allelopathic substances in cucumber plants (2011)
  • Author(s): Kato-Noguchi, H.; Le, T. H.; Teruya, T.; Suenaga, K.
  • Journal Title: Scientia Horticulturae (Amsterdam, Netherlands) Volume: 129 Pages: 894-897
  • Peer Reviewed
• [Journal Article] Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes (2011)
  • Author(s): Choi, S.; Cha, B-Y.; Iida, K.; Sato, M.; Lee, Y-S.; Teruya, T.; Yonezawa, T.; Nagai, K.; Woo, J-T.
  • Journal Title: Journal of Natural Medicines Volume: 65 Pages: 424-430
  • NAID: 10029461740
  • Peer Reviewed
• [Journal Article] Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling (2011)
  • Author(s): Yonezawa, T.; Lee, J-W.; Hibino, A.; Asai, M.; Hojo, H.; Cha, B-Y.; Teruya, T.; Nagai, K.; Chung, U-l; Yagasaki, K.; Woo, Je-Tae.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 409 Pages: 260-265
  • Peer Reviewed
• [Journal Article] N,N'-diphenethylurea isolated from Okinawan ascidian Didemnum molle enhances adipocyte differentiation in 3T3-L1 cells (2011)
  • Author(s): Choi, S-S.; Cha, B-Y.; Kagami, I.; Lee, Y-S.; Sasaki, H.; Suenaga, K.; Teruya, T.; Yonezawa, T.; Nagai, K.; Woo, J-T.
  • Journal Title: Journal of Antibiotics Volume: 64 Pages: 277-280
  • NAID: 10030638432
  • Peer Reviewed
• [Journal Article] Artepillin C, as a PPARγ ligand, enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells (2011)
  • Author(s): Choi, S-S.; Cha, B-Y.; Iida, K.; Lee, Y-S.; Yonezawa, T.; Teruya, T.; Nagai, K.; Woo, J-T.
  • Journal Title: Biochemical Pharmacology Volume: 81 Pages: 925-933
  • Peer Reviewed
• [Journal Article] Revised structure and structure-activity relationship of bisebromoamide and structure of norbisebromoamide from the marine cyanobacterium Lyngbya sp (2011)
  • Author(s): Sasaki, H.; Teruya, T.; Fukazawa, H.; Suenaga, K.
  • Journal Title: Tetrahedron Volume: 67 Pages: 990-994
  • Peer Reviewed
• [Journal Article] Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo (2011)
  • Author(s): Yonezawa, T.; Hasegawa, S.; Asai, M.; Ninomiya, T.; Sasaki, T.; Cha, B-Y.; Teruya, T.; Ozawa, H.; Yagasaki, K.; Nagai, K.; Woo, J.-T.
  • Journal Title: European Journal of Pharmacology Volume: 650 Pages: 511-518
  • Peer Reviewed
• [Journal Article] Revised structure and structure-activity relationship of bisebromoamide and structure of norbisebromoamide from the marine cyanobacterium Lyngbya sp. (2011)
  • Author(s): Sasaki Hiroaki, Teruya Toshiaki, Fukazawa Hidesuke, and Suenaga Kiyotake.
  • Journal Title: Tetrahedron Volume: 67 Issue: 5 Pages: 990-994
  • DOI: 10.1016/j.tet.2010.11.106
  • Peer Reviewed
• [Journal Article] Two potent allelopathic substances in cucumber plants (2011)
  • Author(s): Kato-Noguchi Hisashi, Le Thi Ho, Teruya Toshiaki, and Suenaga Kiyotake.
  • Journal Title: Scientia Horticulturae Volume: 129 Issue: 4 Pages: 894-897
  • DOI: 10.1016/j.scienta.2011.04.031
• [Journal Article] Allelopathy of red pine: isolation and identification of an allelopathic substance in red pine needles (2011)
  • Author(s): Kato-Noguchi Hisashi, Fushimi Yoshiko, Tanaka Yukitoshi, Teruya Toshiaki, and Suenaga Kiyotake.
  • Journal Title: Plant Growth Regulation Volume: 65 Issue: 2 Pages: 299-304
  • DOI: 10.1007/s10725-011-9601-2
• [Presentation] 高脂肪食誘導肥満マウスにおけるシークワーサーエキスの抗肥満効果 (2014)
  • Author(s): 車炳允、浅井みどり、照屋俊明、米澤貴之、金靜、永井和夫、禹済泰
  • Organizer: 日本農芸学会2014年度大会
  • Place of Presentation: 川崎
  • Year and Date: 2014-03-28
• [Presentation] 高脂肪食誘導肥満マウスにおけるシークワーサーエキスの抗肥満効果 (2014)
  • Author(s): 車炳允・浅井みどり・照屋俊明・米澤 貴之・金孝靜・永井和夫・禹済泰
  • Organizer: 日本農芸学会2014年度大会
  • Place of Presentation: 明治大学生田キャンパス
• [Presentation] 破骨細胞の機能に対するBiselymgbyasideの作用 (2013)
  • Author(s): 照屋俊明、米澤貴之、間瀬直美、佐々木宏明、末永聖武、車炳允、禹済泰、永井和夫
  • Organizer: 第15回マリンバイオテクノロジー学会大会
  • Place of Presentation: 那覇
  • Year and Date: 2013-06-01
• [Presentation] 海洋微細藻類由来新規チアゾール化合物tomurulineの構造と生物活性 (2013)
  • Author(s): 大野修、佐名恭平、照屋俊明、清水史郎、末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-25
• [Presentation] 海洋産マクロリド Biselyngbyaside類の構造と生物活性 (2013)
  • Author(s): 森田真布、大野修、照屋俊明、佐々木宏明、末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-25
• [Presentation] 海洋シアノバクテリア由来のマクロリド biselyngbyolide Bの単離と構造 (2013)
  • Author(s): 森田真布、大野修、照屋俊明、佐々木宏明、末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-25
• [Presentation] アクチン脱重合活性物質レイジスポンジオリド Aの合成研究 (2013)
  • Author(s): 鈴木一司、秋山、聡史、鳥居原英輔、照屋俊明、大野修、末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-25
• [Presentation] 破骨細胞の機能に対するBiselyngbyasideの作用 (2013)
  • Author(s): 照屋俊明・米澤貴之・間瀬直美・佐々木宏明・末永聖武・車炳允・禹済泰・永井和夫
  • Organizer: 第15回マリンバイオテクノロジー学会
  • Place of Presentation: 沖縄県市町村自治会館
• [Presentation] アクチン脱重合活性物質Reidispongiolide Aの合成研究 (2012)
  • Author(s): 鈴木一司、秋山、聡史、鳥居原英輔、深澤英吾、照屋俊明、大野修、末永聖武
  • Organizer: 第54回天然有機化合物討論会
  • Place of Presentation: 世田谷
  • Year and Date: 2012-09-18
• [Presentation] 海洋シアノバクテリア由来の新規マクロリドLeptolyngbyolide類の生物活性 (2012)
  • Author(s): 森田真布、大野修、照屋俊明、末永聖武
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-27
• [Presentation] 海洋シアノバクテリア由来のマクロリドBiselyngbyaside類の単離と構造 (2012)
  • Author(s): 森田真布、大野修、照屋俊明、末永聖武
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-27
• [Presentation] アクチン脱重合活性物質レイジスポンジオリドAの合成研究 (2012)
  • Author(s): 鈴木一司、鳥居原英輔、秋山、聡史、照屋俊明、大野修、末永聖武
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-27
• [Presentation] リュウキュウスガモ抽出物が付着生物幼生に与える影響について (2012)
  • Author(s): 末吉康佑、中野義勝、井口亮、照屋俊明
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-26
• [Presentation] 海洋シアノバクテリア由来新規環状デプシペプチドの単離と構 造決定 (2012)
  • Author(s): 梶山雄司・大野修・照屋俊明・末永聖武
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
• [Presentation] リュウキュウスガモ抽出物が付着生物幼生に与える影響につ いて (2012)
  • Author(s): 末吉康佑・中野義勝・井口亮・照屋俊明
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
• [Presentation] 海洋シアノバクテリア由来の新規マクロリドLeptolyngbyolide 類の生物活性 (2012)
  • Author(s): 森田真布・大野修・照屋俊明・末永聖 武
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
• [Presentation] 海洋シアノバクテリア由来のマクロリドBiselyngbyaside類の単 離と構造 (2012)
  • Author(s): 森田真布・大野修・照屋俊明・末永聖武
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
• [Presentation] アクチン脱重合活性物質レイジスポンジオリドA の合成研究 (2012)
  • Author(s): 鈴木一司・鳥居原英輔・秋山聡史・照屋俊明・大野 修・末永聖武
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
• [Presentation] 海洋シアノバクテリア由来の新規マクロリド Biselyngbyaside類の構造と生物活性 (2011)
  • Author(s): 森田真布、大野修、照屋俊明、北将樹、木越英夫、北村和大、平田邦生、末永聖武
  • Organizer: 第53回天然有機化合物討論会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-27
• [Presentation] 海洋産マクロリドBiselyngbyaside類の構造と生物活性
  • Author(s): 森田真布・大野修・照屋俊明・佐々木宏明・末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学 びわこ・くさつキャンパス（BKC）
• [Presentation] 海洋シアノバクテリア由来のマクロリドbiselyngbyolide Bの単離と構造
  • Author(s): 渡邊絢音・森田真布・大野修・照屋俊明・末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学 びわこ・くさつキャンパス（BKC）
• [Presentation] アクチン脱重合活性物質レイジスポンジオリドAの合成研究
  • Author(s): 鈴木一司・秋山聡史・鳥居原英輔・照屋俊明・大野修・末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学 びわこ・くさつキャンパス（BKC）
• [Presentation] 海洋微細藻類由来新規チアゾール化合物tomurulineの構造と生物活性
  • Author(s): 大野修・佐名恭平・照屋俊明・清水史郎・末永聖武
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学 びわこ・くさつキャンパス（BKC）
• [Book] Marine Pharmacognosy (2013)
  • Author(s): Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga.
  • Publisher: CRC Press (Taylor and Francis Group)
• [Book] Bioactive Compounds from Okinawan Marine Cyanobacteria. Se-Kwon Kim (Ed.), Marine Pharmacognosy:Trends and Applications (2012)
  • Author(s): Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga
  • Publisher: CRC Press