The role of lipid metabolism in brain functions and sleep
Project/Area Number |
23730706
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental psychology
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Research Institution | The University of Tokushima |
Principal Investigator |
CHIKAHISA Sachiko 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00452649)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 脂質代謝 / 睡眠 / 高次脳機能 / ケトン体 / PPARα |
Research Abstract |
We investigated the role of brain lipid metabolism in higher brain functions including sleep regulations. Six-hour sleep deprivation markedly increased plasma ketone body concentration in mice. Moreover, sleep deprivation activated ketogenesis in the brain. We also found that icv injection of ketone bodies enhanced sleep depth and decreased glutamate release in freely moving mice. In the brain, astrocyte is known to produce ketone bodies from fatty acids. Lipid metabolism in the astrocyte may play a significant role in brain functions including sleep homeostasis.
|
Report
(4 results)
Research Products
(42 results)
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[Presentation] 脳内脂質代謝と睡眠2012
Author(s)
近久幸子,勢井宏義
Organizer
日本睡眠学会第37回定期学術集会(シンポジウム)
Place of Presentation
パシフィコ横浜(神奈川県・横浜市)
Related Report
Invited
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