Catalytic Asymmetric Synthesis of Chiral Fluorinated Molecules
| Project/Area Number |
23750111
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Synthetic chemistry
|
|---|
| Research Institution | Toyohashi University of Technology |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 有機合成 / フッ素化学 / 不斉合成 / ルイス酸触媒 / Diels-Alder反応 / マイケル付加反応 / フッ素化合物 / トリフルオロメチル基 / シキミ酸 / 光学活性触媒 |
|---|
| Research Abstract |
Introduction of a trifluoromethyl group into biologically active compounds often modifies their physical and/or biological properties. Here, we have succeeded in the enantioselective Diels-Alder reaction of β-trifluoromethylacrylates to give corresponding cyclohexenes having a trifluoromethyl group at the chiral carbon center. We also demonstrated the organocatalytic asymmetric 1,4-addition of 4,4,4-trifluorocrotonaldehyde.The resulting adducts could be converted into potential synthetic intermediates for new drug candidates.
|
Report
(3 results)
Research Products
(25 results)
