Development of procedures to prepare monoclonal plastic antibodies
| Project/Area Number |
23750193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyushu University |
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Principal Investigator |
HOSHINO Yu 九州大学, 工学(系)研究科(研究院), 准教授 (40554689)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生体認識 / 機能化学 / 生体機能材料 / プラスチック抗体 / リビング重合 / メリチン / 多官能性高分子 / 分子認識 / ナノ粒子 / ペプチド / NIPAm / モノクローナル / RAFT重合 |
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| Research Abstract |
In this research, we aimed to establish procedures to prepare uniform polymer ligands that interact with target peptide. We first identified the minimum number and combination of functional group on the polymer ligands to capture target peptide melittin. We next showed that polymers with strong affinity to melittin can be isolated by affinity purification procedure. As a final step, library of block copolymers were prepared and optimum sequence to capture melittin was assigned.
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Report
(4 results)
Research Products
(55 results)
