Nonlinear Spatio-Temporal Dynamics of Electroporation: Modeling, Analysis, and Control

• Project/Area Number: 23760390
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Control engineering
• Research Institution: Kyoto University
• Principal Investigator: SUSUKI Yoshihiko 京都大学, 大学院・工学研究科, 講師 (40402961)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: エレクトロポレーション / 非線形動力学 / 制御技術 / 制御工学 / バイオテクノロジー / 電気機器工学 / マイクロマシン / 流体工学

Research Abstract

The goal of this research was to establish a control technology of electroporation in a single cell. Towards the goal, I analyzed nonlinear spatio-temporal dynamics emerging in electroporation of a single cell and synthesized a control protocol for regulating the electroporation. A new control protocol using amplitude-modulated electric fields for regulating the cell membrane permittivity was developed and demonstrated in numerical simulations.

Research Products

• [Presentation] 振幅変調電界によるエレクトロポレーションの一検討 (2013)
  • Author(s): 薄 良彦
  • Organizer: 電子情報通信学会技術報告
  • Place of Presentation: 福岡
  • Year and Date: 2013-05-28
• [Presentation] A numerical study on electroporation by amplitude -modulated electric field (2013)
  • Author(s): Yoshihiko Susuki
  • Organizer: Proceedings of the 2013 International Symposium on Nonlinear Theory and its Applications (NOLTA2013)
  • Place of Presentation: Santa Fe, USA
• [Presentation] 振幅変調電界を用いたエレクトロポレーションの一検討 (2013)
  • Author(s): 薄 良彦
  • Organizer: 電子情報通信学会 非線形問題研究会
  • Place of Presentation: 福岡大学
• [Remarks]
  • URL: http://www-lab23.kuee.kyoto-u.ac.jp/susuki