| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
In eukaryotes, kinetochore is built at the centromeric region of chromosomes and they connect chromosome and microtubules during cell division. To understand the molecular mechanisms, we analyzed CENP-SX and CENP-TW complexes. Both were similar to histones but they were more similar to each other. They formed a stable CENP-TWSX tetramer. Biochemical analysis of CENP-TWSX tetramer revealed that its DNA binding property is different from that of CENP-TW or CENP-SX. These analyses suggest that CENP-TWSX complex forms a unique chromatin at eukaryotic centromere
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