| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The survival of human pluripotent stem cells is strictly dependent on the cell-cell interaction. We previously reported that the dissociation-induced cell death is mediated by the activation of a Rho-GEF/Rac-GAP dual factor Abr. The aim of this work is to understand how the cellular adhesion controls Abr activity and cell survival in human ES cells. Current results suggested that although Abr is required for apoptosis of dissociated cells, it is dispensable for cell survival under the clump culture condition. However, we identified the essential contribution of Abr in human ES cell proliferation. Further analyses will be required to totally understand of the Abr function in human ES cell survival or proliferation.
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