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Discover ofnovel bioactive peptide and application-using model organism-

Research Project

Project/Area Number 23780297
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionUniversity of Miyazaki

Principal Investigator

IDA Takanori  宮崎大学, IR 推進機構, 助教 (00381088)

Co-Investigator(Renkei-kenkyūsha) MURAKAMI Noboru  宮崎大学, 農学部・獣医学科, 教授 (80150192)
SANO Hiroko  お茶の水女子大学, お茶大アカデミック プロダクション, 特任助教 (90506908)
Research Collaborator TOMINAGA Hatsumi  宮崎大学, IR 推進機構, 技術職員
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords新規生理活性ペプチド / オーファンGPCR / ショウジョウバエ / 摂食行動 / オーファン受容体 / 生理活性ペプチド / モデル生物
Research Abstract

It is very important to discover a novel bioactive peptide to the orphan receptor. I have discovered 5 novel bioactive peptides in Drosophila, a useful model organism. I tried application to mammal, insect and crustacean. Therefore, I observed that dRYamide modulate feeding behavior and cardiovascular system in mouse and promote hiding sand behavior. CCHamide stimulate feeding behavior in insect.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Book (3 results) Remarks (5 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors2012

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 3 Pages: 177-177

    • DOI

      10.3389/fendo.2012.00177

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different distribution of neuromedin S and its mRNA in the rat brain: NMS peptide is present not only in the hypothalamus as the mRNA, but also in the brainstem2012

    • Author(s)
      Mori M, Mori K, Ida T, Sato T, Kojima M, Miyazato M, Kangawa K
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 3 Pages: 152-152

    • DOI

      10.3389/fendo.2012.00152

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of neuromedin U during inflammatory response in the common carp2012

    • Author(s)
      Kono T, Hamasuna S, Korenaga H, Iizasa T, Nagamine R, Ida T, Sakai M
    • Journal Title

      Fish Shellfish Immunol

      Volume: 32 Issue: 1 Pages: 151-160

    • DOI

      10.1016/j.fsi.2011.11.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variety of Acyl Modificationsin Mammalian Ghrelins2012

    • Author(s)
      Ida T
    • Journal Title

      Methods in Enzymology

      Volume: 514 Pages: 63-73

    • DOI

      10.1016/b978-0-12-381272-8.00004-0

    • ISBN
      9780123812728
    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of the endogenous cysteine-rich peptide trissin, ligand for an orphan G-protein-coupled receptor in Drosophila2011

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagae K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414 Issue: 1 Pages: 44-48

    • DOI

      10.1016/j.bbrc.2011.09.018

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozak Mi, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Issue: 4 Pages: 872-877

    • DOI

      10.1016/j.bbrc.2011.06.081

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Continuous Antagonism of the Ghrelin Receptor Results in Early Induction of Salt-Sensitive Hypertension2011

    • Author(s)
      Takahiro Sato, Yoshiki Nakashima, Yuki Nakamura, Takanori Ida, Masayasu Kojima
    • Journal Title

      J. Mol. Neurosci

      Volume: 43巻 Issue: 2 Pages: 193-199

    • DOI

      10.1007/s12031-010-9414-1

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ショウジョウバエ新規生理活性ペプチドの発見と応用2012

    • Author(s)
      井田隆徳、富永初美、岩元絵里、粂和彦、佐藤貴弘、佐野浩子、平口鉄太郎、尾崎まみこ、宮里幹也、寒川賢治、児島将康
    • Organizer
      第37回日本比較内分泌学会大会
    • Place of Presentation
      福井
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 家畜グレリンの精製と応用2012

    • Author(s)
      富永初美、岩元絵里、井田隆徳、保田昌宏、桑野睦敏、児島将康、宮里幹也、寒川賢治、加藤丈司
    • Organizer
      第37回日本比較内分泌学会大会
    • Place of Presentation
      福井
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] ショウジョウバエ新規生理活性ペプチドの発見と応用2012

    • Author(s)
      井田隆徳
    • Organizer
      第37回日本比較内分泌学会大会
    • Place of Presentation
      福井市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 家畜グレリンの精製と応用2012

    • Author(s)
      富永初美
    • Organizer
      第37回日本比較内分泌学会大会
    • Place of Presentation
      福井市
    • Related Report
      2012 Annual Research Report
  • [Presentation] モデル生物を利用した新規生理活性ペプチドの探索2011

    • Author(s)
      井田隆徳、佐藤貴弘、児島将康
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規生理活性ペプチドの探索-モデル生物を利用して-2011

    • Author(s)
      井田隆徳
    • Organizer
      第5回トランスポーター研究会 九州部会
    • Place of Presentation
      宮崎
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] ショウジョウバエ新規生理活性ペプチドの発見2011

    • Author(s)
      井田隆徳
    • Organizer
      第4回分子高次機能研究会
    • Place of Presentation
      熊本
    • Year and Date
      2011-08-28
    • Related Report
      2012 Final Research Report
  • [Presentation] モデル生物を利用した新規生理活性ペプチドの探索2011

    • Author(s)
      井田隆徳、佐藤貴弘、児島将康
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学
    • Related Report
      2011 Research-status Report
  • [Book] ペプチド医薬の最前線2012

    • Author(s)
      井田隆徳、児島将康、加藤丈司
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] ペプチド医薬の最前線2012

    • Author(s)
      井田隆徳
    • Total Pages
      5
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Annual Research Report
  • [Book] Methods in Enzymology2012

    • Author(s)
      Ida T
    • Total Pages
      11
    • Publisher
      Elsevier Inc.
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.cc.miyazaki-u.ac.jp/a0d203u/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 宮崎大学IR推進機構 井田研究室

    • URL

      http://www.cc.miyazaki-u.ac.jp/a0d203u/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 宮崎大学型若手研究リーダー育成モデル

    • URL

      http://www.miyazaki-u.ac.jp/ir/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.cc.miyazaki-u.ac.jp/a0d203u/index.html

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.miyazaki-u.ac.jp/ir/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] ショウジョウバエ由来生理活性ペプチドdRYamide2012

    • Inventor(s)
      井田隆徳 児島将康
    • Industrial Property Rights Holder
      宮崎大学 久留米大学
    • Filing Date
      2012-03-26
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ショウジョウバエ由来生理活性ペプチドdRYamide2011

    • Inventor(s)
      井田隆徳 児島将康
    • Industrial Property Rights Holder
      井田隆徳 児島将康
    • Industrial Property Number
      2011-085684
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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