Analysis of ubiquitin modification regulating heterochromatin structure
| Project/Area Number |
23780351
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIRAI Atsuko 独立行政法人理化学研究所, 眞貝細胞記憶研究室, 研究員 (60525575)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ヘテロクロマチン / ユビキチン化修飾 / Cul4ユビキチンリガーゼ / ヒストンメチル化酵素 / RNA / ユビキチン化 / 非ヒストン / 分裂酵母 / 非ヒストンタンパク質 |
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| Research Abstract |
In eukaryotes, heterochromatin mediates diverse biological processes including gene silencing and regulation of long-range chromatin interaction. However, the mechanism underlying heterochromatin formation is poorly understood. Our study showed that non-cording RNA in mammals involved in heterochromatin formation and the subunit of highly conserved RNA polymerase II was ubiquitinated by Cul4 ubiquitin ligase.
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Report
(4 results)
Research Products
(8 results)
