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Intravital FRET Monitoring for Systematic Evaluation of Drug Delivery Systems

Research Project

Project/Area Number 23790043
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUMOTO Yu  東京大学, 医学部附属病院, 助教 (80548553)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsドラッグデリバリー / 生体イメージング
Research Abstract

Efficient drug delivery system (DDS) must fulfill paradoxical requirements as it should secure the cargo in the off-target environment, and also release the cargo at the target cells. Using a combination of Forster resonance energy transfer (FRET) and intravital imaging techniques, the intravital distribution and intactness of the DDS was evaluated. Intravital performance of the DDS was assessed in many aspects such as blood circulation studies, tissue distribution, intracellular stability, and release of the nucleic acid.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (126 results)

All 2014 2013 2012 2011 Other

All Journal Article (40 results) (of which Peer Reviewed: 35 results,  Open Access: 2 results) Presentation (72 results) (of which Invited: 3 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (8 results) (of which Overseas: 4 results)

  • [Journal Article] An Injectable Spheroid System with Genetic Modification for Cell Transplantation Therapy2014

    • Author(s)
      Uchida S, Itaka K, Nomoto T, Endo T, Matsumoto Y, Ishii T, Kataoka K
    • Journal Title

      Biomaterials

      Volume: 35 Pages: 2499-506

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicompartment Micelles with Adjustable Poly(Ethylene Glycol) Shell for Efficient in Vivo Photodynamic Therapy2014

    • Author(s)
      Synatschke CV, Nomoto T, Cabral H, Fortsch M, Toh K, Matsumoto Y, Miyazaki K, Hanisch A, Schacher FH, Kishimura A, Nishiyama N, Muller AH, Kataoka K
    • Journal Title

      ACS Nano

      Volume: 8 Pages: 1161-72

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aggregation Behavior of Cationic Nanohydrogel Particles in Human Blood Serum2014

    • Author(s)
      Nuhn L, Gietzen S, Mohr K, Fischer K, Toh K, Miyata K, Matsumoto Y, Kataoka K, Schmidt M, Zentel R
    • Journal Title

      Biomacromolecules

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-Layered Polyplex Micelle as a Multifunctional Nanocarrier Platform for Light-Induced Systemic Gene Transfer2014

    • Author(s)
      Nomoto T, Fukushima S, Kumagai M, Machitani K, Arnida, Matsumoto Y, Oba M, Miyata K, Osada K, Nishiyama N, Kataoka K
    • Journal Title

      Nat Commun

      Volume: 5 Pages: 3545-3545

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted Gene Delivery by Polyplex Micelles with Crowded PEG Palisade and cRGD Moiety for Systemic Treatment of Pancreatic2014

    • Author(s)
      Tumors, Ge Z, Chen Q, Osada K, Liu X, Tockary TA, Uchida S, Dirisala A, Ishii T, Nomoto T, Toh K, Matsumoto Y, Oba M, Kano MR, Itaka K, Kataoka K
    • Journal Title

      Biomaterials

      Volume: 35 Pages: 316-26

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014

    • Author(s)
      Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
    • Journal Title

      Drug Delivery and Translational Research

      Volume: 4 Issue: 1 Pages: 50-60

    • DOI

      10.1007/s13346-013-0175-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An injectable spheroid system with genetic modification for cell transplantation therapy2014

    • Author(s)
      Uchida S, ltaka K, Nomoto T, Endo T, Matsumoto Y, Ishii T, Kataoka K
    • Journal Title

      Biomaterials

      Volume: 35(8) Issue: 8 Pages: 2499-506

    • DOI

      10.1016/j.biomaterials.2013.12.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicompartment micelles with adjustable poly (ethylene glycol) shell for efficient in vivo photodynamic therapy2014

    • Author(s)
      C. V. Synatschke, N. Nishiyama, et al.
    • Journal Title

      ACS Nano

      Volume: (in press)(印刷中)(掲載確定) Issue: 2 Pages: 1161-1172

    • DOI

      10.1021/nn4028294

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggregation Behavior of Cationic Nanohydrogel Particles in Human Blood Serum2014

    • Author(s)
      L. Nuhn, S. Gietzen, K. Mohr, K. Fischer, K. Toh, K. Miyata, Y. Matsumoto, K. Kataoka, M. Schmidt, R. Zentel
    • Journal Title

      Biomacromolecules

      Volume: Article ASAP Issue: 4 Pages: 1526-1533

    • DOI

      10.1021/bm500199h

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer2014

    • Author(s)
      T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 3545-3545

    • DOI

      10.1038/ncomms4545

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors2014

    • Author(s)
      Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 10 Pages: 3416-3426

    • DOI

      10.1016/j.biomaterials.2013.12.086

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 他領域からのトピックスナノバイオテクノロジーを応用した医療イノベーション2013

    • Author(s)
      松本有,山岨達也,片岡一則
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 113 Pages: 133-139

    • Related Report
      2013 Final Research Report
  • [Journal Article] A Toolbox of Differently Sized and Labeled PMMA Nanoparticles for Cellular Uptake Investigations2013

    • Author(s)
      Vollrath A, Schallon A, Pietsch C, Schubert S, Nomoto T, Matsumoto Y, Kataoka K, Schubert US
    • Journal Title

      Soft Matter

      Volume: 9 Pages: 99-108

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers2013

    • Author(s)
      Tockary TA, Osada K, Chen Q, Machitani K, Dirisala A, Uchida S, Nomoto T, Toh K, Matsumoto Y, Itaka K, Nitta K, Nagayama K, Kataoka K
    • Journal Title

      Macromolecules

      Volume: 46 Pages: 6585-6592

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood-Brain Tumor Barrier2013

    • Author(s)
      Miura Y, Takenaka T, Toh K, Wu S, Nishihara H, Kano MR, Ino Y, Nomoto T, Matsumoto Y, Koyama H, Cabral H, Nishiyama N, Kataoka K
    • Journal Title

      ACS Nano

      Volume: 7 Pages: 8583-92

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipid Envelope-Type Nanoparticle Incorporating a Multifunctional Peptide for Systemic SiRNA Delivery to the Pulmonary Endothelium2013

    • Author(s)
      Kusumoto K, Akita H, Ishitsuka T, Matsumoto Y, Nomoto T, Furukawa R, El-Sayed A, Hatakeyama H, Kajimoto K, Yamada Y, Kataoka K, Harashima H
    • Journal Title

      ACS Nano

      Volume: 7 Pages: 73534-41

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multifunctional Polyion Complex Micelle Featuring Enhanced Stability, Targetability, and Endosome Escapability for Systemic SiRNA Delivery to Subcutaneous Model of Lung Cancer2013

    • Author(s)
      Kim HJ, Ishii T, Zheng M, Watanabe S, Toh K, Matsumoto Y, Nishiyama N, Miyata K, Kataoka K, Drug Delivery and Translational
    • Journal Title

      Research

      Volume: 4 Pages: 50-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 他領域からのトピックス ナノバイオテクノロジーを応用した医療イノベーション2013

    • Author(s)
      松本有, 山岨達也, 片岡一則
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 113 Pages: 133-139

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A toolbox of differently sized and labeled PMMA nanoparticles for cellular uptake investigations2013

    • Author(s)
      A. Vollrath, A. Schallon, C. Pietsch, S. Schubert, T. Nomoto, Y. Matsumoto, U. S. Schubert, K. Kataoka
    • Journal Title

      Soft Matter

      Volume: 9(1) Issue: 1 Pages: 99-108

    • DOI

      10.1039/c2sm26928g

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier2013

    • Author(s)
      Y. Miura, N. Nishiyama, et al.
    • Journal Title

      ACS Nano

      Volume: 7 Issue: 10 Pages: 8583

    • DOI

      10.1021/nn402662d

    • URL

      https://localhost/en/publications/3467d27d-2dd8-4c3f-989a-c9fd3270117c

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Lipid Envelop-type Nano Particle Incorporating a Multifunctional Peptide: GALA for the Systemic siRNA Delivery to the Pulmonary Endothelium.2013

    • Author(s)
      Kusumoto K, Akita H, Ishitsuka T, Matsumoto Y, Nomoto T, Furukawa R, El-Sayed A, Hatakeyama H, Kajimoto K, Yamada Y, Kataoka K, Harashima H.
    • Journal Title

      ACS Nano.

      Volume: 7 Issue: 9 Pages: 7534-7541

    • DOI

      10.1021/nn401317t

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リアルタイム生体内共焦点レーザ顕微鏡を用いたDrug Delivery Systems(DDS)の動態評価法2012

    • Author(s)
      野本貴大,松本有,藤加珠子, Christie RJ,宮田完二郎,大庭誠, Cabral H,村上真美,福島重人,西山伸宏,片岡一則
    • Journal Title

      薬学雑誌

      Volume: 132 Pages: 1347-54

    • NAID

      130002489530

    • Related Report
      2013 Final Research Report
  • [Journal Article] PEG-Detachable Cationic Polyaspartamide Derivatives Bearing Stearoyl Moieties for Systemic SiRNA Delivery toward Subcutaneous BxPC3 Pancreatic Tumor2012

    • Author(s)
      Kim HJ, Oba M, Pittella F, Nomoto T, Cabral H, Matsumoto Y, Miyata K, Nishiyama N, Kataoka K
    • Journal Title

      J Drug Target

      Volume: 20 Pages: 33-42

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted Polymeric Micelles for SiRNA Treatment of Experimental Cancer by Intravenous Injection2012

    • Author(s)
      Christie RJ, Matsumoto Y, Miyata K, Nomoto T, Fukushima S, Osada K, Halnaut J, Pittella F, Kim HJ, Nishiyama N, Kataoka K
    • Journal Title

      ACS Nano

      Volume: 6 Pages: 5174-89

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Micellization of Cisplatin (NC-6004) Reduces its Ototoxicity in Guinea Pigs2012

    • Author(s)
      Baba M, Matsumoto Y, Kashio A, Cabral H, Nishiyama N, Kataoka K, Yamasoba T
    • Journal Title

      J Control Release

      Volume: 157 Pages: 112-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual antrostomy optical window for visualising sinus cavity during implant restoration2012

    • Author(s)
      Y. Matsumoto, T. Okuno, Y. Hasegawa, M. Kuwauchi
    • Journal Title

      BMJ Case Rep

      Volume: なし Pages: bcr0220125869-bcr0220125869

    • DOI

      10.1136/bcr.02.2012.5869

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection2012

    • Author(s)
      R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H. -J. Kim, N. Nishiyama, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 6(6) Issue: 6 Pages: 5174-5189

    • DOI

      10.1021/nn300942b

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs2012

    • Author(s)
      M.Baba, N.Nishiyama, et al.
    • Journal Title

      J.Control.Release

      Volume: 157 Issue: 1 Pages: 112-117

    • DOI

      10.1016/j.jconrel.2011.07.026

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ムコイド型肺炎球菌を起因菌とした耳性頭蓋内合併症の2例2012

    • Author(s)
      桑内麻也子, 奥野妙子, 畑裕子, 松本有, 小嶋康隆
    • Journal Title

      Otology Japan

      Volume: 22 Pages: 141-147

    • NAID

      10030646737

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 先天性真珠腫手術症例39例の検討2012

    • Author(s)
      小嶋康隆, 奥野妙子, 畑裕子, 松本有, 田中友佳子, 井之口豪
    • Journal Title

      Otology Japan

      Volume: 22 Pages: 17-22

    • NAID

      10030285412

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] リアルタイム生体内共焦点レーザ顕微鏡を用いた drug delivery systems(DDS)の動態評価法2012

    • Author(s)
      野本貴大, 松本有, 藤加珠子, R. J. Christie, 宮田完二郎, 大庭誠, H. Cabral, 村上真美, 福島重人, 西山伸宏, 片岡一則
    • Journal Title

      薬学雑誌

      Volume: 132 Pages: 1347-1354

    • NAID

      130002489530

    • Related Report
      2012 Research-status Report
  • [Journal Article] In Situ Quantitative Monitoring of Polyplexes and Polyplex Micelles in the Blood Circulation Using Intravital Real-Time Confocal Laser Scanning Microscopy2011

    • Author(s)
      Nomoto T, Matsumoto Y, Miyata K, Oba M, Fukushima S, Nishiyama N, Yamasoba T, Kataoka K
    • Journal Title

      J Control Release

      Volume: 151 Pages: 104-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] I mproving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting2011

    • Author(s)
      Murakami M, Cabral H, Matsumoto Y, Wu S, Kano MR, Yamori T, Nishiyama N, Kataoka K
    • Journal Title

      Sci Transl Med

      Volume: 3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Polymer Structure on Micelles Formed between Sirna and Cationic Block Copolymer Comprising Thiols and Amidines2011

    • Author(s)
      Christie RJ, Miyata K, Matsumoto Y, Nomoto T, Menasco D, Lai TC, Pennisi M, Osada K, Fukushima S, Nishiyama N, Yamasaki Y, Kataoka K
    • Journal Title

      Biomacromolecules

      Volume: 12 Pages: 3174-85

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of Sub-100 Nm Polymeric Micelles in Poorly Permeable Tumours Depends on Size2011

    • Author(s)
      Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M, Terada Y, Kano MR, Miyazono K, Uesaka M, Nishiyama N, Kataoka K
    • Journal Title

      Nat Nanotechnol

      Volume: 6 Pages: 815-23

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] PEG-detachable cationic polyaspartamide detivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor2011

    • Author(s)
      H.-J.Kim, N.Nishiyama, et al
    • Journal Title

      J.Drug Target.

      Volume: 20 Issue: 1 Pages: 33-42

    • DOI

      10.3109/1061186x.2011.632010

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生体内リアルタイム共焦点顕微鏡2011

    • Author(s)
      松本有, 野本貴大, 藤加珠子, 片岡一則
    • Journal Title

      Drug Delivery System

      Volume: 26 Pages: 535-539

    • Related Report
      2011 Research-status Report
  • [Journal Article] Effect of polymer structure on micelles formed between siRNA and cationic block copolymer Comprising thiols and amidines2011

    • Author(s)
      R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T.-C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka
    • Journal Title

      Biomacromolecules

      Volume: 12(9) Issue: 9 Pages: 3174-3185

    • DOI

      10.1021/bm2006714

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size2011

    • Author(s)
      H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka
    • Journal Title

      Nature Nanotech

      Volume: 6(12) Issue: 12 Pages: 815-823

    • DOI

      10.1038/nnano.2011.166

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 下咽頭神経鞘腫の1例2011

    • Author(s)
      田中友佳子, 栗田宣彦, 松本有, 原田品子, 佐多由紀, 畑裕子, 小嶋康隆, 奥野妙子
    • Journal Title

      耳鼻咽喉科・頭頚部外科

      Volume: 83 Pages: 595-599

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Intravital Confocal Microscopy Assay for the Evaluation of Antioxidant Capacity2014

    • Author(s)
      Matsumoto Y
    • Organizer
      37th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
    • Place of Presentation
      Manchester Grand Hyatt Hotel, San Diego, CA, USA
    • Year and Date
      2014-02-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravital Imaging of Drug Delivery Systems and Auditory Hair Cells2013

    • Author(s)
      Matsumoto Y
    • Organizer
      12th Taiwan-Japan Conference on Otolaryngology Head and Neck Surgery
    • Place of Presentation
      National Taiwan University Hospital, Taipei City, Taiwan
    • Year and Date
      2013-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravital Calcium Imaging of Cochlear Hair Cells Upon Sound Stimulation2013

    • Author(s)
      Matsumoto Y
    • Organizer
      50th Inner Ear Biology Workshop
    • Place of Presentation
      Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravital Calcium Imaging of Cochlear Hair Cells2013

    • Author(s)
      Matsumoto Y
    • Organizer
      36th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
    • Place of Presentation
      Baltimore Marriott Waterfront Hotel, Baltimore, MD, USA
    • Year and Date
      2013-02-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravital Confocal Microscopy for Dds Evaluation and Development2013

    • Author(s)
      Matsumoto Y, Sheraton
    • Organizer
      16th International Symposium on Recent Advances in Drug Delivery Systems
    • Place of Presentation
      Salt Lake City Hotel, Salt Lake City, UT, USA
    • Year and Date
      2013-02-06
    • Related Report
      2013 Final Research Report
  • [Presentation] DDS Evaluation Using Intravital Real-Time Laser Scanning Confocal Microscopy2013

    • Author(s)
      Matsumoto Y
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Intravital Microscopy for DDS Evaluation and Development2013

    • Author(s)
      Matsumoto Y
    • Organizer
      The 12th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      The Westin Maui Resort and Spa, Lahaina, Maui, HI, USA
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Enhanced blood circulation of siRNA complexed with PEG-block-poly(L-lysine) for cancer treatment2013

    • Author(s)
      S. Watanabe, H. Chaya, T. Nomoto, S. Fukushima, K. Toh, H. Takemoto, X. Liu, Y. Matsumoto, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intravital Monitoring of Intact siRNA Using Fluorescence Resonance Energy Transfer2013

    • Author(s)
      K. Toh, T. Nomoto, Y. Matsumoto, S. Watanabe, S. Fukushima, H. Chaya, R. J. Christie, K. Miyata, N. Nishiyama, K. Kataoka
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tethering PEG density on polyplex micelles and stealthiness in blood circulation2013

    • Author(s)
      K. Osada, T. Tockary, Q. Chen, A. Dirisala, K. Machitani, T. Nomoto, Y. Matsumoto, K. Kataoka
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhanced Antitumor Activity of Proteasome Inhibitor MG132-loaded Polymeric Micelle Drug Carriers2013

    • Author(s)
      Y. Matsumoto, Y. Miyamoto, K. Nagasaka, Y. Matsumoto, H. Cabral, H. Nishida, R. J. Christie, K. Kawana, T. Fujii, N. Nishiyama, K. Kataoka
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of enzyme-loaded PICsomes for enzyme/prodrug therapy2013

    • Author(s)
      Y. Anraku, A. Kishimura, M. Kamiya, S. Tanaka, T. Nomoto, K. Toh, Y. Matsumoto, M. R. Kano, Y. Urano, N. Nishiyama, K. Kataoka
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] PIC型ベシクルの特徴を活かした酵素プロドラッグ療法用キャリアの構築2013

    • Author(s)
      安楽泰孝, 岸村顕広, 神谷真子, 田中さやか, 野本貴大, 藤加珠子, 松本有, 狩野光伸, 浦野泰照, 西山伸宏, 片岡一則
    • Organizer
      第62回高分子学会年次大会
    • Place of Presentation
      京都国際会館、京都府京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] siRNA 1 分子封入ポリイオンコンプレックスの構築と siRNA デリバリーへの展開2013

    • Author(s)
      宮田完二郎, 茶谷洋行, 渡邉秀美代, 林光太朗, 野本貴大, 藤加珠子, 松本有, 武元宏泰, 西山伸宏, 長田健介, 片岡一則
    • Organizer
      第35回日本バイオマテリアル学会
    • Place of Presentation
      タワーホール船堀、東京都江戸川区
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体内顕微鏡下におけるFörster Resonance Energy Transferを利用した血中siRNA安定性の定量的評価2013

    • Author(s)
      藤加珠子, 野本貴大, 松本有, 渡邉秀美代, 福島重人, 茶谷洋行, R. J. Christie, 宮田完二郎, 西山伸宏, 片岡一則
    • Organizer
      第35回日本バイオマテリアル学会
    • Place of Presentation
      タワーホール船堀、東京都江戸川区
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡の手技の実際2012

    • Author(s)
      松本有
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Year and Date
      2012-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡によるDDS挙動解析2012

    • Author(s)
      松本有
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Year and Date
      2012-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡の手技の実際(招待講演)2012

    • Author(s)
      松本有
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 生体内リアルタイム共焦点顕微鏡によるDDS挙動解析(招待講演)2012

    • Author(s)
      松本有
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Size-mediated Accumulation of Sub-100 nm Polymeric Micelles in Poorly Permeable Tumors2012

    • Author(s)
      H. Cabral, 松本有, 狩野光伸, 西山伸宏, 片岡一則
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡を用いたポリイオンコンプレックスの定量的血中動態評価2012

    • Author(s)
      野本貴大, 松本有, 宮田完二郎, 大庭誠, 福島重人, 西山伸宏, 片岡一則
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺血管内皮細胞標的型siRNAキャリアの標的メカニズムとその抗腫瘍効果2012

    • Author(s)
      楠本憲司, 秋田英万, 松本有, 野本貴大, 片岡一則, 原島秀吉
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] インプラント治療に伴う上顎洞炎・自然口および対孔Optical Windowを利用した長期経過観察2012

    • Author(s)
      松本有, 小嶋康隆, 田中友佳子, 桑内麻也子, 畑裕子, 栗田宣彦, 山岨達也, 奥野妙子
    • Organizer
      第113回日本耳鼻咽喉科学会・学術講演会
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] 耳の「低侵襲内視鏡」手術: transmeatal approach2012

    • Author(s)
      奥野妙子, 畑裕子, 栗田宣彦, 松本有, 小嶋康隆, 桑内麻也子
    • Organizer
      第113回日本耳鼻咽喉科学会・学術講演会
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] 当科における耳硬化症の聴力像の検討2012

    • Author(s)
      桑内麻也子, 奥野妙子, 小嶋康隆, 松本有, 畑裕子, 栗田宣彦
    • Organizer
      第113回日本耳鼻咽喉科学会・学術講演会
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] 当科における耳硬化症手術症例の画像所見と治療成績2012

    • Author(s)
      小嶋康隆, 奥野妙子, 畑裕子, 阿部彰子, 松本有, 栗田宣彦, 桑内麻也子
    • Organizer
      第113回日本耳鼻咽喉科学会・学術講演会
    • Place of Presentation
      朱鷺メッセ、新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] Enhanced Blood Circulation Properties of siRNA Nanocarriers by Fine-tuning of PEG-block-Poly(L-lysine)2012

    • Author(s)
      S. Watanabe, H. Chaya, K. Miyata, T. Nomoto, S. Fukushima, H. Takemoto, K. Toh, L. Xueying, Y. Matsumoto, K. Osada, N. Nishiyama, K. Kataoka
    • Organizer
      6th Annual Symposium on Nanobiotechnology Kyoto Cell-Material Integration
    • Place of Presentation
      Shirankaikan, Kyoto University, Kyoto, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] A Light-responsive Nanodevice Based on Photochemical Internalization2012

    • Author(s)
      T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, K. Miyata, M. Oba, Y. Matsumoto, K. Osada, N. Nishiyama, K. Kataoka
    • Organizer
      6th Annual Symposium on Nanobiotechnology Kyoto Cell-Material Integration
    • Place of Presentation
      Shirankaikan, Kyoto University, Kyoto, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Targeted Polymeric Micelles for siRNA Cancer Therapy Administered by Intravenous Injection2012

    • Author(s)
      R. J. Christie, Y. Matsumoto, S. Fukushima, T. Nomoto, K. Miyata, K. Osada, F. Pittella, H. J. Kim, H. Nishida, N. Nishiyama, K. Kataoka
    • Organizer
      NanoBio Seattle 2012 (The Fourth International NanoBio Conference)
    • Place of Presentation
      Bell Harbor International Conference Center, Seattle, WA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Imaging DDS Using Intravital Real-Time Confocal Microscopy2011

    • Author(s)
      Matsumoto Y
    • Organizer
      The 11th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      The Westin Maui Resort and Spa, Lahaina, Maui, HI, USA
    • Year and Date
      2011-12-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡と蝸牛イメージングへの展開2011

    • Author(s)
      松本有
    • Organizer
      第21回日本耳科学会総会
    • Place of Presentation
      学術講演会,沖縄コンベンションセンター、沖縄県宜野湾市
    • Year and Date
      2011-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡を用いたDDS機能評価2011

    • Author(s)
      松本有
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学、東京都文京区
    • Year and Date
      2011-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravital Confocal Micro - Videography2011

    • Author(s)
      Matsumoto Y
    • Organizer
      International Conference on Biomaterials Science (ICBS) 2011
    • Place of Presentation
      Tsukuba International Congress Center, Tsukuba, Ibaraki, Japan
    • Year and Date
      2011-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravital Real-Time Confocal Laser Scanning Microscopy for In Situ Evaluation of Nanocarriers2011

    • Author(s)
      Yu Matsumoto, Takahiro Nomoto, Kazuko Toh, Kanjiro Miyata, Horacio Cabral, R. James Christie, Yoko Matsumoto, Nobuhiro Nishiyama, Tatsuya Yamasoba, Kazunori Kataoka
    • Organizer
      The 11th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡と蝸牛イメージングへの展開2011

    • Author(s)
      松本有, 狩野章太郎, 吉川弥生, 奥野妙子, 片岡一則, 山岨達也
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄県宜野湾市
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体内リアルタイム共焦点顕微鏡を用いたDDS機能評価2011

    • Author(s)
      松本有, 野本貴大, カブラルオラシオ, 村上真美, 西山伸宏, 山崎裕一, 山岨達也, 片岡一則
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学本郷キャンパス, 東京都文京区
    • Related Report
      2011 Research-status Report
  • [Presentation] Clinical Course and Features of Fatal Intersititial Pneumonitis Induced by PEGylated Liposomal Doxorubicin (PLD) and Analysis of PLD-Induced Lung Injury Using Real-Time Intravital Microscope2011

    • Author(s)
      Yoko Matsumoto, Takahide Arimoto, Katsutoshi Oda, Kei Kawana, Tetsu Yano, Yuji Taketani, Yu Matsumoto, Takahiro Nomoto, Kazuko Toh, Kazunori Kataoka
    • Organizer
      The 11th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Observation and Analysis of Radiation-Induced Vascular Permeability to Improve the Delivery of Polymeric Micelles by IVRTCLSM2011

    • Author(s)
      Hiroshi Fujisawa, Horacio Cabral, Takahiro Nomoto, Mitsuru Uesaka, Kazue Mizuno, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      The 11th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Quantitative evaluation of dynamic states of polyplexes and polyplex micelles in blood stream using intravital real-time confocal laser scanning microscopy2011

    • Author(s)
      Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Makoto Oba, Shigeto Fukushima, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      The 11th US-Japan Symposium on Drug Delivery Systems
    • Place of Presentation
      The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] ダイビングが誘因となった急性聴覚前庭障害の2症例2011

    • Author(s)
      畑裕子, 小嶋康隆, 松本有, 田中友佳子, 桑内麻也子, 馬場美雪, 奥野妙子, 池園哲朗
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄県宜野湾市
    • Related Report
      2011 Research-status Report
  • [Presentation] 中耳真珠腫進展度分類2010改訂案に基づいた真珠腫性中耳炎の手術成績の検討2011

    • Author(s)
      小嶋康隆, 奥野妙子, 畑裕子, 松本有, 桑内麻也子
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄県宜野湾市
    • Related Report
      2011 Research-status Report
  • [Presentation] 肺炎球菌を起炎菌とした耳性頭蓋合併症の2例2011

    • Author(s)
      桑内麻也子, 奥野妙子, 畑裕子, 松本有, 小嶋康隆
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄県宜野湾市
    • Related Report
      2011 Research-status Report
  • [Presentation] シスプラチン内包高分子ミセルの内耳毒性軽減効果2011

    • Author(s)
      馬場美雪, 松本有, 樫尾明憲, 片岡一則, 山岨達也
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄県宜野湾市
    • Related Report
      2011 Research-status Report
  • [Presentation] 若手耳科医師の教育プログラム2011

    • Author(s)
      奥野妙子, 畑裕子, 松本有, 小嶋康隆
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄県宜野湾市
    • Related Report
      2011 Research-status Report
  • [Presentation] In Situ Monitoring of Drug Delivery Systems Using Intravital Real-time Confocal Laser Scanning Microscopy2011

    • Author(s)
      Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Makoto Oba, Shigeto Fukushima, Horacio Cabral, Mami Murakami, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      Seoul Nanohealth 2011 Symposium
    • Place of Presentation
      Yonsei University, Seoul, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] A Photo-activated Nanodevice Having Three Functional Compartments for Efficient Gene Delivery2011

    • Author(s)
      Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kanjiro Miyata, Yu Matsumoto, Makoto Oba, Woo-dong Jang, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      Seoul Nanohealth 2011 Symposium
    • Place of Presentation
      Yonsei University, Seoul, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] PEG-detachable polyaspartamide derivative block copolymer bearing stearoyl moieities for in vivo siRNA delivery2011

    • Author(s)
      Kim Hyun Jin, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学津島キャンパス、岡山県岡山市
    • Related Report
      2011 Research-status Report
  • [Presentation] 21.Subcellular delivery of DACHPt by polymeric micelles overcomes oxaliplatin resistance in Human Colon Carcinoma2011

    • Author(s)
      Mami Murakami, Horacio Cabral, Yu Matsumoto, Shourong Wu, Takao Yamori, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      38th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Gaylord National Hotel and Convention Center, National Harbor, Maryland, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 22.Quantitative Monitoring of Polyplexes and Polyplex Micelles in Bloodstream Using Intravital Real-time Confocal Laser Scanning Microscopy2011

    • Author(s)
      Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Makoto Oba, Shigeto Fukushima, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      38th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Gaylord National Hotel and Convention Center, National Harbor, Maryland, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Characterization of PEG-detachable polyaspartamide derivative block catiomers bearing stearoyl moieties and its VEGF siRNA delivery toward Bxpc3 xenograft tumor2011

    • Author(s)
      Kim Hyun Jin, Makoto Oba, Frederico Pittella, Horacio Cabral, Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      38th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Gaylord National Hotel and Convention Center, National Harbor, Maryland, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] シスプラチン内包高分子ミセルによる内耳障害軽減効果2011

    • Author(s)
      馬場美雪, 松本有, カブラルオラシオ, 西山伸宏, 片岡一則, 山岨達也
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学本郷キャンパス, 東京都文京区
    • Related Report
      2011 Research-status Report
  • [Presentation] PEG-detachable polyaspartamide derivative block copolymer bearing stearoyl moieities for VEGF siRNA delivery toward pancreatic tumor2011

    • Author(s)
      Kim Hyun Jin, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学本郷キャンパス, 東京都文京区
    • Related Report
      2011 Research-status Report
  • [Presentation] シリカ被覆型核酸デリバリーキャリアの開発2011

    • Author(s)
      宮田完二郎, Noha Gouda, 須磨知也, 松本有, 大庭誠, 西山伸宏, 片岡一則
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学本郷キャンパス, 東京都文京区
    • Related Report
      2011 Research-status Report
  • [Presentation] 光選択的遺伝子導入を可能とする全身投与型三層構造高分子ミセル

    • Author(s)
      野本貴大, 福島重人, 熊谷康顕, 町谷香織, 松本有, 大庭誠, 宮田完二郎, 長田健介, 西山伸宏, 片岡一則
    • Organizer
      第62回高分子討論会
    • Place of Presentation
      金沢大学、石川県金沢市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 耳かきによる外傷性耳小骨離断の陳旧例2症例

    • Author(s)
      畑裕子, 堤内亮博, 小嶋康隆, 藤田岳, 山本沙織, 松本有, 宇野茉莉子, 桑内麻也子, 一瀬和美, 奥野妙子,
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      シーガイアコンベンションセンター、宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 顕微鏡と内視鏡の相補的アプローチ

    • Author(s)
      松本有, 藤田岳, 宇野茉莉子, 畑裕子, 奥野妙子
    • Organizer
      第114回日本耳鼻咽喉科学会・学術講演会
    • Place of Presentation
      ロイトン札幌、北海道札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 蝸牛有毛細胞のカルシウムイメージング

    • Author(s)
      松本有, 狩野章太郎, 山岨達也
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      シーガイアコンベンションセンター、宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
  • [Presentation] PIC型ベシクルの特徴を活かした酵素プロドラッグ療法用キャリアの構築

    • Author(s)
      安楽泰孝, 岸村顕広, 神谷真子, 田中さやか, 野本貴大, 藤加珠子, 松本有, 狩野光伸, 浦野泰照, 西山伸宏, 片岡一則
    • Organizer
      遺伝子・デリバリー研究会 第13回夏期セミナー
    • Place of Presentation
      Hawaii Prince Hotel Waikiki, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 汎用性の高い酵素プロドラッグ療法用キャリアを指向した血中滞留型中空ナノ粒子(PICsome)の構築

    • Author(s)
      安楽泰孝, 岸村顕広, 神谷真子, 田中さやか, 野本貴大, 藤加珠子, 松本有, 狩野光伸, 浦野泰照, 西山伸宏, 片岡一則
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都テルサ、京都府京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 内視鏡は先天性真珠腫の手術に有効か?

    • Author(s)
      奥野妙子, 松本有, 藤田岳, 堤内亮博, 宇野茉莉子, 畑裕子, 栗田宣彦
    • Organizer
      第114回日本耳鼻咽喉科学会・学術講演会
    • Place of Presentation
      ロイトン札幌、北海道札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 耳つぼ金粒の耳管内迷入

    • Author(s)
      大山博生, 五十嵐一紀, 松本有, 樫尾明憲, 柿木章伸, 山岨達也
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      シーガイアコンベンションセンター、宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 耳小骨連鎖を温存した先天性・後天性真珠腫手術症例の検討

    • Author(s)
      堤内亮博, 奥野妙子, 松本有, 藤田岳, 宇野茉莉子, 山本沙織, 畑裕子
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      シーガイアコンベンションセンター、宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 3 次元スフェロイド細胞培養とナノミセルによる遺伝子導入を融合した新規細胞移植システム

    • Author(s)
      内田智士, 位高啓史, 遠藤泰輔, 野本貴大, 松本有, 片岡一則
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都テルサ、京都府京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Polymeric Micellar Nanocarriers for Systemic Light-Induced Gene Delivery

    • Author(s)
      T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, K. Miyata, M. Oba, Y. Matsumoto, K. Osada, N. Nishiyama, K. Kataoka
    • Organizer
      第13回東京大学生命科学シンポジウム
    • Place of Presentation
      伊藤国際学術研究センター、東京都文京区
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intravital Calcium Imaging of Cochlear Hair Cells Upon Sound Stimulation

    • Author(s)
      Y. Matsumoto, S. Karino, S. Namiki, K. Kataoka, T. Yamasoba
    • Organizer
      50th Inner Ear Biology Workshop
    • Place of Presentation
      Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] Systemically injected polymeric micelles can inhibit the growth of lymph node metastasis

    • Author(s)
      H. Cabral, J. Makino, Y. Matsumoto, Y. Miura, M. R. Kano, N. Nishiyama, K. Kataoka
    • Organizer
      frontiers 2013 symposium
    • Place of Presentation
      EPFL, Lausanne, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of Nano‐sized Polyion Complex Vesicles (Nano‐PICsomes) as a Versatile Delivery Carrier for Biomedical Application

    • Author(s)
      Y. Anraku, A. Kishimura, D. Kokuryo, S. I. Tanaka, M. Kamiya, K. Toh, T. Nomoto, Y. Matsumoto, I. Aoki, M. R. Kano, Y. Urano, K. Kataoka
    • Organizer
      frontiers 2013 symposium
    • Place of Presentation
      EPFL, Lausanne, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intravital Imaging of Drug Delivery Systems and Auditory Hair Cells

    • Author(s)
      Y. Matsumoto, K. Kataoka, T. Yamasoba
    • Organizer
      12th Taiwan-Japan Conference on Otolaryngology Head and Neck Surgery
    • Place of Presentation
      International Convention Center, National Taiwan University Hospital, Taipei City, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Intravital Confocal Microscopy Assay for the Evaluation of Antioxidant Capacity

    • Author(s)
      Y. Matsumoto, K. Toh, K. Kataoka, T. Yamasoba
    • Organizer
      37th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
    • Place of Presentation
      Manchester Grand Hyatt Hotel, San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimal-sized, long-circulating single siRNA nanocarrier for intractable cancer therapy

    • Author(s)
      H. Chaya, S. Watanabe, K. Hayashi, H. Takemoto, S. Fukushima, T. Nomoto, K. Toh, Y. Matsumoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka
    • Organizer
      第13回東京大学生命科学シンポジウム
    • Place of Presentation
      伊藤国際学術研究センター、東京都文京区
    • Related Report
      2013 Annual Research Report
  • [Presentation] ナノミセルを用いて遺伝子導入された3次元スフェロイド細胞の移植とその疾患治療への展開

    • Author(s)
      内田智士, 位高啓史, 遠藤泰輔, 柳原歌代子, 野本貴大, 石井武彦, 松本有, 片岡一則
    • Organizer
      遺伝子・デリバリー研究会 第13回夏期セミナー
    • Place of Presentation
      Hawaii Prince Hotel Waikiki, Honolulu, HI, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞接着分子カドヘリン11は中耳の正常な発達に必須である

    • Author(s)
      吉川弥生, 木下淳, 松本有, 山岨達也
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      シーガイアコンベンションセンター、宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
  • [Book] Intravital Real-Time Confocal Laser Scanning Microscopy for the in Situ Evaluation of Nanocarriers2013

    • Author(s)
      Matsumoto Y, Nomoto T, Toh K, Cabral H, Murakami M, Christie RJ, Kim HJ, Ogura T, Miyata K, Nishiyama N, Yamasoba T, Kataoka K, Cancer Targeted Drug Delivery, Bae, Y. H., Mrsny, R. J., and Park, K.s. Bae, Y. H., Mrsny, R. J., and Park, K
    • Publisher
      Springer New York
    • Related Report
      2013 Final Research Report
  • [Book] Cancer Targeted Drug Delivery2013

    • Author(s)
      Y. Matsumoto, T. Nomoto, K. Toh, H. Cabral, M. Murakami, R. J. Christie, H. J. Kim, T. Ogura, K. Miyata, N. Nishiyama, T. Yamasoba, K. Kataoka
    • Total Pages
      720
    • Publisher
      Springer New York
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] Welcome to KKlab homepage

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 片岡一則-FIRST EXPO2014

    • URL

      http://first-pg.jp/about-us/kataoka-kazunori.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/index.html

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びに投与方法2013

    • Inventor(s)
      片岡一則,安楽泰孝,西山伸宏,宮田 完二郎,石井武彦,松本有,福里優,溝口明祐,横田隆徳,桑原宏哉,仁科一隆,水澤英洋
    • Industrial Property Rights Holder
      東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学部附属病院,東京大学工学系研究科,東京大学医学系研究科,国立大学法人東京医科歯科大学,国立大学法人東京医科歯科大学,国立大学法人東京医科歯科大学,国立大学法人東京医科歯科大学
    • Industrial Property Number
      2013-242347
    • Filing Date
      2013-11-22
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物2012

    • Inventor(s)
      片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
    • Industrial Property Rights Holder
      東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
    • Filing Date
      2012-01-16
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物2012

    • Inventor(s)
      片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
    • Industrial Property Rights Holder
      東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
    • Industrial Property Number
      2011-006318
    • Filing Date
      2012-01-14
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物2012

    • Inventor(s)
      片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
    • Industrial Property Rights Holder
      東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
    • Industrial Property Number
      2012-552778
    • Filing Date
      2012-01-16
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物2012

    • Inventor(s)
      片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
    • Industrial Property Rights Holder
      東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
    • Filing Date
      2012-01-16
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 名称:粒子組成物および該粒子組成物を用いた医薬組成物2012

    • Inventor(s)
      片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
    • Industrial Property Rights Holder
      東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
    • Filing Date
      2012-01-16
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 複合体微粒子およびその製造方法、ならびに該複合体微粒子を用いた薬学組成物2011

    • Inventor(s)
      片岡一則,宮田完二郎,西山伸宏,大 庭誠,山崎裕一,須磨知也,グダノハ,武元宏泰,松本有,野本貴大
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2011-552789
    • Filing Date
      2011-02-02
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 複合体微粒子およびその製造方法、ならびに該複合体微粒子を用いた薬学組成物2011

    • Inventor(s)
      片岡一則,宮田完二郎,西山伸宏,大 庭誠,山崎裕一,須磨知也,グダノハ,武元宏泰,松本有,野本貴大
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Filing Date
      2011-02-02
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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