Examination of reaction products the lipid radical and biomolecule.
| Project/Area Number |
23790053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Nihon Pharmaceutical University |
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Principal Investigator |
TAKAJO Tokuko 日本薬科大学, 薬学部, 講師 (80424068)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脂質過酸化 / 酵素反応 / 非酵素反応 / 酵素 / ラジカル |
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| Research Abstract |
In lipid peroxidation reaction,it is measured without distinguishing these reaction products, which oxidative stress caused by reactive oxygen species or radicals reaction products and the biological enzymatic reaction products. Therefore, it is considered to be important for oxidative stress prevention by an antioxidant agent to distinguish these reaction products. I investigated whether there are differences in the reaction products produced by the reaction with biomolecular substances and enzymatic reaction by lipoxygenase, a chemical reaction by the radical generator, the physical reaction by UV irradiation. As a result, the reaction intermediates generated in the physical reaction and enzymatic reactions and chemical reactions, no difference was observed in the reaction product.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] YC2014
Author(s)
Yang HL, Huang PJ, Liu YR, Kumar KJ, Hsu LS, Lu TL, Chia YC, Takajo T, Kazunori A, Hseu YC
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Journal Title
Oxid Med Cell Longev
Volume: 2014
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access
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