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Examination of reaction products the lipid radical and biomolecule.

Research Project

Project/Area Number 23790053
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionNihon Pharmaceutical University

Principal Investigator

TAKAJO Tokuko  日本薬科大学, 薬学部, 講師 (80424068)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脂質過酸化 / 酵素反応 / 非酵素反応 / 酵素 / ラジカル
Research Abstract

In lipid peroxidation reaction,it is measured without distinguishing these reaction products, which oxidative stress caused by reactive oxygen species or radicals reaction products and the biological enzymatic reaction products. Therefore, it is considered to be important for oxidative stress prevention by an antioxidant agent to distinguish these reaction products. I investigated whether there are differences in the reaction products produced by the reaction with biomolecular substances and enzymatic reaction by lipoxygenase, a chemical reaction by the radical generator, the physical reaction by UV irradiation. As a result, the reaction intermediates generated in the physical reaction and enzymatic reactions and chemical reactions, no difference was observed in the reaction product.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] YC2014

    • Author(s)
      Yang HL, Huang PJ, Liu YR, Kumar KJ, Hsu LS, Lu TL, Chia YC, Takajo T, Kazunori A, Hseu YC
    • Journal Title

      Oxid Med Cell Longev

      Volume: 2014 Pages: 1-16

    • DOI

      10.1155/2014/901315

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 抗酸化評価のためのスピントラップ法におけるFenton反応の検討2013

    • Author(s)
      高城徳子
    • Organizer
      第52回電子サイエンス学会年会(SEST2013)
    • Place of Presentation
      さいたま市
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗酸化評価のためのスピントラップ法におけるFenton反応の検討2013

    • Author(s)
      高城徳子、田口貴将、福間隆元、揚薪玲、張淑貞、土田和徳、窪田洋子、安西和紀
    • Organizer
      第52回電子サイエンス学会
    • Place of Presentation
      さいたま市
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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