The exploration of antidepressant effects in the hypothalamic nuclei
| Project/Area Number |
23790084
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
SEGI Eri 京都大学, 大学院・薬学研究科, 特定准教授 (70378628)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 神経生物学 / 抗うつ治療 / 遺伝子発現 / 視床下部 / 摂食 / 電気けいれん療法 / 高脂肪食 |
|---|
| Research Abstract |
The purpose of the study is to explore antidepressant effects of electroconvulsive seizures (ECS) in the hypothalamic nuclei.
(1) ECS down-regulates gene expression of cholecystokinin, which is suggested as a modulator of the stress responses, in the paraventricular hypothalamus.
(2) ECS up-regulates gene expression of anorexigenic factors in the ventromedial hypothalamus, and decreases food intake via ventromedial hypothalamus function. This study suggests a role in the regulation energy homeostasis by ECS.
|
Report
(3 results)
Research Products
(17 results)
-
[Journal Article] Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus.2013
Author(s)
Segi-Nishida, E., Sukeno, M., Imoto, Y., Kira, T., Sakaida, M., Tsuchiya, S., Sugimoto, Y., and Okuno, Y.
-
Journal Title
Neuropharmacol.
Volume: 71
Pages: 164-173
DOI
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Prostaglandin E_2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice2012
Author(s)
Tanaka, K.,* Furuyashiki, T.*#, Kitaoka, S.*, Senzai, Y.*, Imoto, Y., Segi-Nishida, E., Deguchi, Y., Breyer, R.M., Breyer, M.D., Narumiya, S.#(*equally contribut ed; #co-corresponding authors)
-
Journal Title
J.Neurosci.
Volume: 32
Issue: 12
Pages: 4319-4329
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Prostaglandin E_2-EP4signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism2011
Author(s)
Inazumi, T., Shirata, N., Morimoto, K., Takano, H., Nishida, S.E., Sugimoto, Y.
-
Journal Title
J Lipid Res
Volume: 52
Issue: 8
Pages: 1500-1508
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
