Studies on isolation, total syntheses and structure-activity relationship of plants alkaloids with AChE inhibitory activity
| Project/Area Number |
23790124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
KOGURE Noriyuki 千葉大学, 大学院・薬学研究院, 助教 (80396689)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アルカロイド / アセチルコリンエステラーゼ / リコポジウム / ヒガンバナ / 不斉全合成 / 構造決定 |
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| Research Abstract |
This research was aimed for the search of plant alkaloids which has AChE inhibitory activity by separation from Lycopodium and Amaryllidaceae plants, chemical total synthesis of natural alkaloids. As a result, we succeeded in the isolation and structure elucidation of many new alkaloids and achieved the total syntheses of several kinds of natural alkaloids.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Synthesis and Biological Evaluation of 4-Chlorocolchicine Derivatives as Potent Anticancer Agents with Broad Effective Dosage Ranges2012
Author(s)
H. Nishiyama, M. Ono, T. Sugimoto, T.Sasai, N. Asakawa, T. Matsumoto, T. Yaegashi, M. Nagaoka, T. Matsuzaki, N. Kogure, M. Kitajima, and H. Takayama
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Journal Title
Med. Chem. Comm
Volume: 3(12)
Issue: 12
Pages: 1500-1504
DOI
Related Report
Peer Reviewed
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