In vivo imaging of the dynamics of the regulation of bone metabolism
| Project/Area Number |
23790248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJIMORI Sayumi 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (20589717)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨芽細胞 / 破骨細胞 / 骨リモデリング / 細胞間相互作用 / イメージング |
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| Research Abstract |
Little is known about the cellular behavior of osteoblasts and osteoclasts in bone tissue in vivo. To elucidate the mechanisms of the maintenance of bone homeostasis and the pathogenesis of bone diseases by visualization of the dynamics of bone remodeling in live bone tissues, we performed intravital two-photon imaging of osteoblasts and osteoclasts in the mouse calvarial bones in the physiological and pathological conditions such as osteoporosis.
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Report
(3 results)
Research Products
(7 results)
