Elucidation of the role of hypothalamic Sirt1 in energy balance regulation.
| Project/Area Number |
23790270
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Gunma University |
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Principal Investigator |
SASAKI Tsutomu 群馬大学, 生体調節研究所, 准教授 (50466687)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 視床下部 / Sirt1 / 摂食調節 / エネルギー消費 / 交感神経 / 褐色脂肪 / sirtuin / 摂食 |
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| Research Abstract |
In order to address the role of Sirt1, an NAD^+-dependent deacetylase, in regulating energy balance, we analyzed POMC or AgRP Sirt1 conditional knock-in mice. We found that Sirt1 in POMC neurons stimulates energy expenditure through sympathetic nervous system while Sirt1 in AgRP neurons suppresses food intake, thereby negatively regulating energy balance. Meanwhile we found that diet-induced obesity suppresses the function of hypothalamic Sirt1 and promotes positive energy balance.
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Report
(3 results)
Research Products
(31 results)
