Research on the physiological roles of TRP channels in astrocyte activation induced by a lipid mediator
Project/Area Number |
23790294
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KANEKO Shuji 京都大学, 大学院・薬学研究科, 教授 (60177516)
NAKAGAWA Takayuki 京都大学, 大学院・薬学研究科, 准教授 (30303845)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 脂質メディエーター / スフィンゴシン-1-リン酸 (S1P) / アストロサイト / TRPチャネル / TRPC3 / 細胞内カルシウム動態 / 形態変化 / CXCL1 / S1P / ケモカイン / カルシウム動態 / スフィンゴシン-1ーリン酸 / アラキドン酸 / Ca2+動態 |
Research Abstract |
Sphingosine-1-phosphate (S1P) is a biologically active lipid that has an important role in regulating the growth, survival and migration of a variety of cells; however their roles in the brain remain to be elucidated. Transient Receptor Potential Canonical (TRPC) channels, Ca^<2+>-permeable nonselective cation channels, are expressed in astrocytes and involved in Ca^<2+>influx after G-coupled receptor stimulation. In the present study, we demonstrate that S1P-induced Ca^<2+>responses and resultant CXCL1 release can be attributed to TRPC-mediated extracellular Ca^<2+>entry in culturedastrocytes. Further investigations are required to identify the mechanisms of S1P-evoked astrocyte activation
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide2012
Author(s)
Konno M, Shirakawa H, lida S, Sakimoto S, Matsutani I, Miyake T,Kageyama K, Nakagawa T, Shibasaki K, Kaneko, S.
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Journal Title
Glia
Volume: 60
Issue: 5
Pages: 761-770
DOI
Related Report
Peer Reviewed
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[Presentation] Stimulation of TRPV4 channel suppresses aberrant activation of microglia induced by lipopolysaccharide.2011
Author(s)
Konno, M., Shirakawa, H., Iida, S., Sakimoto, S., Nakagawa, T., Shibasaki, K., Kaneko, S.
Organizer
The 6th SKO Symposium
Place of Presentation
ソウル(韓国)
Related Report
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[Presentation] Involvement of TRPM2 channel in mechanisms underlying microglial activation.2011
Author(s)
Shirakawa, H., Kusano, A., Miyake, T., Konno, M., Nakagawa, T., Kaneko, S.
Organizer
第34回日本神経科学大会
Place of Presentation
パシフィコ横浜(神奈川県)
Related Report
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[Presentation] Functional coupling of TRPC1 and TRPC3 in thrombin-induced astrocyte activation.2011
Author(s)
Shirakawa, H., Konno, M., Munakata, M., Sakimoto, S., Nakagawa, T., Kaneko, S.
Organizer
The 41th Annual Meeting of the Society for Neuroscience
Place of Presentation
ワシントンDC(米国)
Related Report
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