Elucidation of the pathogensis of aortic aneurysm and dissection by the use of mice lacking all nitric oxide synthases.
Project/Area Number |
23790300
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
|
Research Institution | University of the Ryukyus |
Principal Investigator |
ARAKAKI Kumiko 琉球大学, 医学部附属病院, 助教 (10568687)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 一酸化窒素合成酵素 / 大動脈瘤 / 大動脈解離 / マウス / 一酸化窒素 / メタボリックシンドローム / 動脈硬化 |
Research Abstract |
The pathogesisis of aortic aneurysm and dissection still remains to be fully clarified. In this study, we examined whether or not the nitric oxide synthases(NOSs) system is involved in the pathogenesis of aortic aneurysm and dissection by using triple NOSs-KO mice. Long-term treatment with a high-fat diet and angiotensinII did not induced aortic aneurysm or dissection in the triple NOSs-KO mice. There may be room for considering experimental conditions.
|
Report
(4 results)
Research Products
(10 results)
-
[Journal Article] Long-Term Treatment With San’o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013
Author(s)
Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Sakanashi M, Uchida T, Kina-Tanada M, Kubota H, Arakaki K, Tanimoto A, Yanagihara N, Sakanashi M, Ohya Y, Masuzaki H, Ishiuchi S, Sugahara K, Tsutsui M
-
Journal Title
Circulation Journal
Volume: 77
Issue: 7
Pages: 1827-1837
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
-
[Journal Article] Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo2011
Author(s)
Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Ishiuchi S, Masuzaki H, Sugahara K, Ohya Y, Sakanashi M, Tsutsui M
-
Journal Title
Am J Physiol Heart Circ Physiol
Volume: 301
Issue: 3
Pages: H721-H729
DOI
Related Report
Peer Reviewed
-
[Presentation] Development of an Experimentally Useful Model of Spontaneous Myocardial Infarction : 2/3 Nephrectomized Triple Nitric Oxide Synthases-Deficient Mouse2014
Author(s)
Uchida T, Furuno Y, Tanimoto H, Arakaki K, Kina M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Ohya Y, Yanagihara N, Shimokawa H, Tamura M, Otsuji Y, Tsutsui M
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Tokyo International Forum, Tokyo, Japan
Year and Date
2014-03-22
Related Report
-
-
-
-
-
-
-
[Presentation] Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo2011
Author(s)
Tsutsui M, Noguchi K, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Sugahara K, Ohya Y
Organizer
American Heart Association, Scientific Sessions 2011
Place of Presentation
Orange County Convention Center, Orlando, USA
Year and Date
2011-11-16
Related Report