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Analyses of lysophospholipid acyltransferase family

Research Project

Project/Area Number 23790324
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research Institution独立行政法人国立国際医療研究センター (2012)
The University of Tokyo (2011)

Principal Investigator

SHINDOU Hideo  独立行政法人国立国際医療研究センター, 脂質シグナリングプロジェクト, 上級研究員 (10401027)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細胞医化学 / リゾリン脂質アシル転移酵素 / リン脂質 / 生理活性 / 脂質 / アレルギー・ぜんそく
Research Abstract

I investigated lysophospholipid acyltransferases as target molecules to generate membrane diversity. Phospholipid composition, mRNA expression and activity of lysophospholipid acyltransferases were examined in differentiated cells (C3H 10T1/2 to adipocytes), mouse testis, and several stages of cell cycle. In this period, I could report that possible contribution of LPCAT3 to adipocyte function, storage of poluunsaturated fatty acids by LPAAT3 to maturate testis function, oscillation of PC-20:4 during cell cycle, and storage of palmitoleic acid (16:1) in PI. In the future, biological roles of lysophospholipid acyltransferases in cells should be further investigated.

Report

(3 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (13 results) (of which Invited: 1 results) Remarks (5 results)

  • [Journal Article] Generation of membrane diversity by lysophospholipid acyltransferases2013

    • Author(s)
      Shindou H, Hishikawa D, Harayama T, Eto M and Shimizu T
    • Journal Title

      J. Biochem

      Volume: (In press)

    • NAID

      40019683274

    • Related Report
      2013 Final Research Report
  • [Journal Article] Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding2013

    • Author(s)
      Koeberle A
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Issue: 7 Pages: 2546-51

    • DOI

      10.1073/pnas.1216182110

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation.2012

    • Author(s)
      Eto M, Shindou H, Koeberle A, Harayama T, Yanagida K, Shimizu T
    • Journal Title

      Int J Mol Sci.

      Volume: 13 Issue: 12 Pages: 16267-80

    • DOI

      10.3390/ijms131216267

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol.2012

    • Author(s)
      Koeberle A, Shindou H, Harayama T, Shimizu T
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 32 Pages: 27244-54

    • DOI

      10.1074/jbc.m111.274829

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyunsaturated fatty acids are incorporated into maturating malemouse germ cells by lysophosphatidic acid acyltransferase 32012

    • Author(s)
      Koeberle, A., Shindou, H., Harayama, T., Yuki, K., and Shimizu, T
    • Journal Title

      FASEB J

      Volume: 26 Issue: 1 Pages: 169-180

    • DOI

      10.1096/fj.11-184879

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3.2012

    • Author(s)
      Koeberle A, Shindou H, Harayama T, Yuki K, Shimizu T.
    • Journal Title

      FASEB J.

      Volume: 26 Pages: 169-180

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Glycerophospholipid biosynthesis by lysophospholipid acyltransferases in the Lands' cycle2012

    • Author(s)
      Hideo Shindou, Daisuke Hishikawa, Takeshi Harayama, Miki, Eto, Ryo Morimoto, and Takao Shimizu
    • Organizer
      日本生化学会大会合同大会
    • Place of Presentation
      福岡 福岡国際会議場 マリンメッセ福岡 シンポジウム
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 血小板活性化因子(PAF)生合成酵素(LPCATs)阻害剤の検討2012

    • Author(s)
      垂井愛、進藤英雄、森本亮、衛藤樹、原山武士、長瀬隆英、清水孝雄
    • Organizer
      肺サーファクタント分子病態研究会
    • Place of Presentation
      札幌医科大学
    • Year and Date
      2012-06-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Discovery of lysophospholipid acyltransferases in the Lands' cycle2012

    • Author(s)
      Hideo Shindou, Daisuke Hishikawa, Takeshi Harayama, Miki, Eto, Ryo Morimoto, Koichi Yuki, and Takao Shimizu
    • Organizer
      4th International Singapore Lipid Symposium
    • Place of Presentation
      National University of Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] Glycerophospholipid biosynthesis by lysophospholipid acyltransferases in the Lands’ cycle2012

    • Author(s)
      Hideo Shindou
    • Organizer
      日本生化学会大会合同大会
    • Place of Presentation
      福岡 福岡国際会議場 マリンメッセ福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血小板活性化因子(PAF)生合成酵素(LPCATs)阻害剤の検討2012

    • Author(s)
      垂井愛
    • Organizer
      肺サーファクタント分子病態研究会
    • Place of Presentation
      札幌医科大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Lyso-PAF分解酵素としてのアルキルグリセロールモノオキシゲナーゼ2011

    • Author(s)
      徳岡涼美、北芳博、進藤英雄、清水孝雄
    • Organizer
      日本生化学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] LPCAT1はリン脂質リモデリングを介して肺のホメオスタシスに重要である2011

    • Author(s)
      原山武士、進藤英雄、清水孝雄
    • Organizer
      日本生化学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺サーファクタント脂質組成調節酵素LPCAT1欠損マウスの解析2011

    • Author(s)
      原山武士、進藤英雄、清水孝雄
    • Organizer
      肺サーファクタント分子病態研究会
    • Place of Presentation
      札幌医科大学
    • Year and Date
      2011-06-25
    • Related Report
      2013 Final Research Report
  • [Presentation] LPCAT1は正常な肺サーファクタント脂質の合成に必須である2011

    • Author(s)
      原山武士、進藤英雄、衛藤樹、清水孝雄
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      ホテル東京ガーデンパレス
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of phospholipid functions through the investigation of remodeling enzymes2011

    • Author(s)
      Takeshi Harayama, Hideo Shindou, and Takao Shimizu
    • Organizer
      Max-Planck
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺サーファクタント脂質組成調節酵素LPCAT1欠損マウスの解析2011

    • Author(s)
      原山武士、進藤英雄、清水孝雄
    • Organizer
      肺サーファクタント分子病態研究会
    • Place of Presentation
      北海道(札幌医科大学)
    • Related Report
      2011 Research-status Report
  • [Presentation] LPCAT1はリン脂質リモデリングを介して肺のホメオスタシスに重要である2011

    • Author(s)
      原山武士、進藤英雄、清水孝雄
    • Organizer
      日本生化学会
    • Place of Presentation
      京都府(国立京都国際会館)
    • Related Report
      2011 Research-status Report
  • [Presentation] Lyso-PAF分解酵素としてのアルキルグリセロールモノオキシゲナーゼ2011

    • Author(s)
      徳岡涼美、北芳博、進藤英雄、清水孝雄
    • Organizer
      日本生化学会
    • Place of Presentation
      京都府(国立京都国際会館)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.ncgmlipidsp.jp/members/1.html

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.ncgmlipidsp.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 進藤英雄

    • URL

      http://square.umin.ac.jp/hshindou/

    • Related Report
      2012 Annual Research Report
  • [Remarks] NCGM脂質シグナリングプロジェクト

    • URL

      http://www.ncgmlipidsp.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/hshindou/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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