Analysis of a novel signaling network that regulates cell growth and division

• Project/Area Number: 23790331
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Kyoto University
• Principal Investigator: ADACHI Makoto 京都大学, 大学院・医学研究科, 助教 (30335244)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 細胞内シグナル伝達 / 細胞質分裂 / 細胞増殖 / X線結晶構造解析 / 遺伝子発現制御 / 癌

Research Abstract

We have previously shown that IQGAP3, an intracellular signaling molecule, is responsible for cell proliferation because of its ability to regulate Ras, a proto-oncogene product. In the present study, we showed that IQGAP3 is directly involved in the process of cytokinesis as well, and the underlying molecular mechanisms were also addressed. In addition, expression of the IQGAP3 gene, which is tightly co-related with the state of cell proliferation, as well as the molecular mechanismswith which IQGAP3 regulates Ras, was also investigated.

Research Products

• [Journal Article] Polarity-dependent distribution of angiomotin localizes Hipposignaling in preimplantation embryos
  • Author(s): Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcon, V.B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., Ohno, M., Marikawa, Y.,Nakao, K., Shimono, A. and Sasaki, H
  • Journal Title: Curr. Biol Volume: (in press)