The significance of Caveolin-1 in experimental kidney disease
| Project/Area Number |
23790423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
YAMAMOTO Izumi 東京慈恵会医科大学, 医学部, 助教 (60600468)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 実験腎炎 / カベオリン / Caveolin-1 / 尿細管間質線維化 / マクロファージ / カベオリン１ / 腎障害モデル / 移植腎病理 / 間質線維化 / 血管内皮細胞 |
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| Outline of Final Research Achievements |
To evaluate the significance of Caveolin-1 in kidney disease, we investigated several experimental kidney disease model using Caveolin-1 knockout, transgenic and wild type mouse.Ischemia reperfusion injury model, unilateral ureteral obstruction (UUO) model, eNOS inhibitor infusion model and anti-VEGF antibody infusion model were applied for this purpuse. We found that each model showed no remarkable change regarding Caveolin-1 expression and Caveolae formation on endothelial cells.Only UUO model and eNOS inhibitor infusion model showed increased tubulointerstitial fibrosis in Caveolin-1 knockout mouse compared with wild type mouse. Further examination revealed that only UUO model showed increased macrophage infiltration compared with wild type mouse.
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Report
(5 results)
Research Products
(2 results)
