Epigenetic mechanism of chronic inflammation-associated human carcinogenesis
| Project/Area Number |
23790456
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
ARAI Eri 独立行政法人国立がん研究センター, 研究所, 研究員 (40446547)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子病理 / 腫瘍 / DNA メチル化 / 炎症 / DNAメチル化 / 前がん状態 / 慢性炎症 / 多段階発がん |
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| Research Abstract |
This study has focused on the significance of epigenome alterations in multistage carcinogenesis associated with chronic inflammation. Genome-wide DNA methylation analysis was performed in cancerous and non-cancerous tissue samples obtained from patients with adenocarcinomas of the lung. For comparison, normal lung tissue samples from patients without any primary lung tumor were also analyzed. DNA methylation profiles, which may generate aggressive adenocarcinomas from the inflammatory background in chronic obstructive pulmonary disease in heavy smokers, were identified. Genome-wide DNA methylation analysis also identified DNA methylation profiles each specific to hepatocarcinogenesis associated with hepatitis B virus (HBV) infection and hepatitis C virus infection (HCV) and DNA methylation profiles shared by HBV-positive and HCV-positive patients.
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Report
(3 results)
Research Products
(49 results)
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[Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.2012
Author(s)
Liu Y, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
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Journal Title
PLoS One
Volume: 7
Issue: 8
Pages: e43403-e43403
DOI
Related Report
Peer Reviewed
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