Study on the interaction between M cells and immune cells in Peyer' spatch.
Project/Area Number |
23790521
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Hokkaido University |
Principal Investigator |
KIMURA Shunsuke 北海道大学, 大学院・医学研究科, 助教 (40444525)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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Keywords | パイエル板 / M細胞 / 粘膜免疫 / 細胞間相互作用 |
Research Abstract |
Peyer's patch (PP) in the small intestine is a primary site for the intestinal immune system. The luminal side of PPs is covered by the follicle-associated epithelium (FAE), which contains M cells, which uptake antigens or macromolecules, and deliver them to dendritic cells inhabiting subepithelial dome region under FAE. CCR1 is a receptor of Ccl9 which is belonging to the CC chemokine family and highly expressed in M cells. We found that CCR1 positive cells inhabit subepithelial dome region, and some of them contact with M cells. Moreover, our study suggests that CCR1 positive cell belongs to a subtype of antigen-producing plasma cells.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.2011
Author(s)
Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura YI, Dohi T, Katsuno T, Yokosuka O, Waguri S, Ohno H.
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Journal Title
Gastroenterology
Volume: 141
Pages: 621-632
Related Report
Peer Reviewed
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