Analysis of the mechanism for the regulation of antibody responses by inflammation-associated remodeling of lymph nodes
| Project/Area Number |
23790525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Jun 東京大学, 大学院・医学系研究科, 助教 (50581831)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 獲得免疫 / リンパ節 / 間質細胞ネットワーク / CD4陽性ヘルパーT細胞 / ゲノムワイド遺伝子発現解析 / 間質ネットワーク / リモデリング / 抗体産生 |
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| Research Abstract |
In this study, I sought to clarify the mechanism for the regulation of antibody responses by lymph node (LN) remodeling. I obtained the following insights through this study: 1) Molecular components of stromal network in LN medulla resembled closely to those in T cell region of the LN; 2) Medullary remodeling of LN mediated by antigen-non-specific B cells regulate the antigen-specific antibody response; 3) Upon activation, fibroblastic reticular cells (FRCs), the major cell type shaping the LN stromal network, undergo the turnover without expansion of their number; 4) Activated FRCs promote the contraction of antigen-specific helper T cell response, thereby affecting the number of follicular helper T cells.
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Report
(3 results)
Research Products
(8 results)
