| Project/Area Number |
23790535
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
KITAWAKI Toshio 京都大学, 医学(系)研究科(研究院), 助教 (50378684)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自然免疫 / 形質細胞様樹状細胞 / I型インターフェロン / 二重レポーターシステム / エンドソーム / IRF7 / レポーターシステム / DNAマイクロアレイ / DNAメチル化解析 / レトロウイルス挿入変異 / 生体防御 / 分子メカニズム |
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| Research Abstract |
Plasmacytoid dendritic cells (pDC) rapidly produce vast amounts of type I interferon in response to nucleic acids. They play an important role in host defense by responding to pathogen-derived nucleic acids. However, they are also involved in the pathogenesis of immune disorders by responding to self-cell-derived nucleic acids. In this project, we performed our research to clarify mechanisms of type I interferon production by pDC, using a human pDC cell line established in our laboratory, by introducing it a dual reporter system that visualize activation dynamics of endosomes.
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