A PET study of neuroinflammation in patients with chronic fatigue syndrome.
| Project/Area Number |
23790749
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka City University |
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Principal Investigator |
NAKATOMI Yasuhito 大阪市立大学, 医学(系)研究科(研究院), 研究員 (90566184)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心療内科学 / CFS / neuroinflammation / ME / PET / 疲労 |
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| Research Abstract |
Nine CFS patients and ten healthy controls underwent 11C-(R)-PK11195 PET. 11C-(R)-PK11195 binds to translocator protein(TSPO) which glia cells express when inflammation begins. The BPND values of 11C- (R)-PK11195 in the cingulate cortex, hippocampus, amygdala, thalamus, midbrain, and pons was 45-199% higher in CFS/ME patients than in healthy controls. In CFS/ME patients, the BPND values of 11C-(R)-PK11195 in the amygdala, thalamus and midbrain positively correlated with cognitive impairment score, the BPND values in the cingulate cortex and thalamus positively correlated with pain score, and the BPND value in the hippocampus positively correlated with depression score.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis : a ^11C-(R)-PK11195 positron emission tomography study2014
Author(s)
Yasuhito Nakatomi, Kei Mizuno, Akira Ishii, Yasuhiro Wada, Masaaki Tanaka, Shusaku Tazawa, Kayo Onoe, Sanae Fukuda, Joji Kawabe, Kazuhiro Takahashi, Yosky Kataoka, Susumu Shiomi, Kouzi Yamaguti, Masaaki Inaba, Hirohiko Kuratsune, Yasuyoshi Watanabe
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Journal Title
The Journal of Nuclear Medicine
Volume: 55(6) (in print)
Related Report
Peer Reviewed
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