The role of S1P signaling in-pulmonary fibrosis, and S1PR1-S1P pathway may be an effective molecular therapeutic strategy for fibrotic lung disease
| Project/Area Number |
23790909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AZUMA Momoyo 徳島大学, 病院, 特任助教 (10403750)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺線維症 / S1P / FTY720 |
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| Research Abstract |
Here, we demonstrated that S1P promoted cell proliferation andmigration of fibloblasts cells.In particular, It markedly increased S1PR1 level in lung tissue and pulmonary fibroblasts. S1P-S1P1pathway may be an effective molecular therapeutic strategy for fibrotic lung diseases.
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Report
(3 results)
Research Products
(7 results)
