• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of resistin-like molecules in natural immune system involving insulin resistance.

Research Project

Project/Area Number 23791047
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionThe Institute for Adult Diseases Asahi Life Foundation

Principal Investigator

KUSHIYAMA Akifumi  公益財団法人朝日生命成人病研究所, その他部局等, 准教授 (30435820)

Co-Investigator(Kenkyū-buntansha) ASANO Tomoichiro  広島大学, 医歯(薬)学総合研究科, 教授 (70242063)
SAKODA Hideyuki  東京大学, 医学部附属病院, 特任講師 (50376464)
KURIHARA Hiroki  東京大学, 医学系研究科, 教授 (20221947)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsインスリン抵抗性 / メタボリックシンドローム / NASH モデル / マクロファージ / 自然免疫 / Relmβ / 分子血管病態
Research Abstract

Resistin-like molecule (RELM) β, secretory protein homologous to resistin, reportedly contributes to local immune response regulation in gut and bronchial epithelial cells. However, we found that activated macrophages also express RELMβ and thus investigated the role of RELMβ in the insulin resistance. In RELMβ KO mice, insulin resistance is ameliorated, and lipid accumulation, inflammation, and fibrosis in liver is ameliorated in NASH model, compared with control mice. Furthermore, ELISA system measuring RELMβ is developed, and now investigating RELMβexpression accompanied with change of dietary habitat.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report

Research Products

(37 results)

All 2013 2012 2011 Other

All Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Journal Article] Resistin-like molecule b in foam cells is involved in atherosclerosis development.2013

    • Author(s)
      Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Pages: 1986-1992

    • DOI
      10.1161/atvbaha.113.301546
    • Related Report
      2012 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice2013

    • Author(s)
      Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T
    • Journal Title

      adipocyte

      Volume: 2(1) Pages: 28-32

    • DOI
      10.4161/adip.21837
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrator complex plays an essential role in adipose differentiation.2013

    • Author(s)
      Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 434 Pages: 0-0

    • DOI
      10.1016/j.bbrc.2013.03.029
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signaling2013

    • Author(s)
      Yuichiro Arima
    • Journal Title

      Nat Commun

      Volume: 3 Pages: 1-11

    • DOI
      10.1038/ncomms2258
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development2013

    • Author(s)
      Kushiyama A
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 20-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan2013

    • Author(s)
      Kushiyama A
    • Journal Title

      J Diabet Invest.

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrator complex plays an essential role in adipose differentiation.2013

    • Author(s)
      Otani Y
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model2012

    • Author(s)
      Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 44526-35

    • DOI
      10.1074/jbc.m112.397133
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development.2012

    • Author(s)
      Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 32 Pages: 291-298

    • DOI
      10.1161/atvbaha.111.234559
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes.2012

    • Author(s)
      Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
    • Journal Title

      American Journal Physiology Endocrinology and Metabolism

      Volume: 302 Pages: 286-296

    • DOI
      10.1152/ajpendo.00324.2011
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications2012

    • Author(s)
      Nakarai, H, Yamashita, A, Nagayasu, S, Iwashita, M, Kumamoto, S, Ohyama, H, Hata, M, Soga, Y, Kushiyama, A, Asano, T, Abiko, Y, Nishimura, F
    • Journal Title

      Innate Immun

      Volume: 18 Pages: 164-170

    • DOI
      10.1177/1753425910393370
    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 andenhances insulin actions and adipogenesis2011

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Pages: 20812-2022

    • DOI
      10.1074/jbc.m110.206904
    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia.2011

    • Author(s)
      Tanaka K, Hara S, Kushiyama A, Ubara Y, Yoshida Y, Mizuiri S, Aikawa A, Kawatzu S
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(3) Pages: 391-397

    • DOI
      10.1007/s10157-011-0420-6
    • NAID
      10029005803
    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity.2011

    • Author(s)
      Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: 300(5) Pages: 1047-54

    • DOI
      10.1152/ajpcell.00416.2010
    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atrio-His (James) accessory pathway and infiltration of γδ T cells in the heart with MELAS2011

    • Author(s)
      Matsuzaki G, Kushiyama A, Uto K, Shoda M, Seko Y
    • Journal Title

      BMJ Case Rep

    • DOI
      10.1136/bcr.09.2010.3359
    • Related Report
      2012 Final Research Report
  • [Presentation] インスリン抵抗性および大血管障害におけるマクロファージ由来resistin like molecule βの意義(Research Travel Grant 受賞)2012

    • Organizer
      第24回 分子糖尿病研究会
    • Place of Presentation
      東京・品川インターシティー
    • Year and Date
      2012-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] A 20-year trend of patients with type 2 diabetes at first diagnosis in urban Japan2012

    • Organizer
      第9回国際糖尿病連合西太平洋地区会議・第4回アジア糖尿病学会学術集会
    • Place of Presentation
      京都・国立京都国際会館
    • Related Report
      2012 Final Research Report
  • [Presentation] インスリン分泌能と関連する血糖変動の指標の特徴2012

    • Organizer
      第55回日本糖尿病学会学術総会
    • Place of Presentation
      神奈川・パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] インスリン分泌能と関連する 血糖変動指標の特徴2012

    • Author(s)
      櫛山暁史
    • Organizer
      第55回日本糖尿病学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multifunctional Cardiography(MCG)を用いた2型糖尿病患者の心筋虚血の検出2012

    • Author(s)
      福井美弥子
    • Organizer
      第55回日本糖尿病学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] A 20-year trend of patients with type 2 diabetes at first diagnosis in urban Japan2012

    • Author(s)
      櫛山暁史
    • Organizer
      2012 IDF-WPR AASD
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] インスリン抵抗性および大血管障害における マクロファージ由来resistin like molecule βの意義2012

    • Author(s)
      櫛山暁史
    • Organizer
      第24回分子糖尿病学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 2型糖尿病患者における骨折リスクに関する横断的研究2011

    • Organizer
      第13回骨粗鬆症学会 健診・骨ドック分科会
    • Place of Presentation
      兵庫・神戸国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanism of atherosclerosis development facilitated by resistin like molecule beta2011

    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都・国立京都国際会館
    • Related Report
      2012 Final Research Report
  • [Presentation] 「キサンチンオキシダーゼ経路のマクロファージ泡沫化と動脈硬化への関与」「CGM からみた血糖変動指標と糖尿病の病態の検討」2011

    • Organizer
      第54回日本糖尿病学会学術総会
    • Place of Presentation
      北海道・さっぽろ芸術文化の館他4箇所
    • Related Report
      2012 Final Research Report
  • [Presentation] 2型糖尿病患者における骨折リスクに関する横断的研究2011

    • Author(s)
      櫛山 暁史
    • Organizer
      第13回骨粗鬆症学会 健診・骨ドック分科会
    • Place of Presentation
      神戸国際会議場(兵庫県 神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mechanism of atherosclerosis development facilitated by resistin like molecule beta2011

    • Author(s)
      櫛山 暁史
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県 神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] キサンチンオキシダーゼ経路のマクロファージ泡沫化と動脈硬化への関与(一般口演)2011

    • Author(s)
      櫛山 暁史
    • Organizer
      第54回日本糖尿病学会学術総会
    • Place of Presentation
      札幌プリンスホテル(北海道 札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] CGMからみた血糖変動指標と 糖尿病の病態の検討(一般口演)2011

    • Author(s)
      金子 由梨
    • Organizer
      第54回日本糖尿病学会学術総会
    • Place of Presentation
      札幌市教育文化会館(北海道 札幌市)
    • Related Report
      2011 Research-status Report
  • [Book] 看護学大辞典 第6版2013

    • Publisher
      メヂカルフレンド社
    • Related Report
      2012 Final Research Report
  • [Book] 看護学大辞典第6版2012

    • Author(s)
      永井良三
    • Total Pages
      2400
    • Publisher
      メヂカルフレンド社
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL
      http://www.asahi-life.or.jp/laboratory/biomolecular.html
    • Related Report
      2012 Final Research Report
  • [Remarks] 朝日生命成人病研究所 研究部 糖尿病代謝科 分子生物学班

    • URL
      http://www.asahi-life.or.jp/laboratory/biomolecular.html
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL
      http://www.asahi-life.or.jp/laboratory/biomolecular.html
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2013

    • Inventor(s)
      浅野 知一郎、櫛山 暁史
    • Industrial Property Rights Holder
      広島大学・朝日生命成人病研究所
    • Acquisition Date
      2013-03-29
    • Acquisition Year
      2013
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 大腸癌、動脈硬化症又はメタボリックシンドロームの検出法2013

    • Inventor(s)
      櫛山暁史
    • Industrial Property Rights Holder
      櫛山暁史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-02-28
    • Application Year
      2013
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2012

    • Inventor(s)
      浅野 知一郎、櫛山 暁史
    • Industrial Property Rights Holder
      広島大学・朝日生命成人病研究所
    • Industrial Property Number
      2013-040964
    • Filing Date
      2012-11-26
    • Application Year
      2012
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi