The role of resistin-like molecules in natural immune system involving insulin resistance.
| Project/Area Number |
23791047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The Institute for Adult Diseases Asahi Life Foundation |
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Principal Investigator |
KUSHIYAMA Akifumi 公益財団法人朝日生命成人病研究所, その他部局等, 准教授 (30435820)
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| Co-Investigator(Kenkyū-buntansha) |
ASANO Tomoichiro 広島大学, 医歯(薬)学総合研究科, 教授 (70242063)
SAKODA Hideyuki 東京大学, 医学部附属病院, 特任講師 (50376464)
KURIHARA Hiroki 東京大学, 医学系研究科, 教授 (20221947)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | インスリン抵抗性 / メタボリックシンドローム / NASH モデル / マクロファージ / 自然免疫 / Relmβ / 分子血管病態 |
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| Research Abstract |
Resistin-like molecule (RELM) β, secretory protein homologous to resistin, reportedly contributes to local immune response regulation in gut and bronchial epithelial cells. However, we found that activated macrophages also express RELMβ and thus investigated the role of RELMβ in the insulin resistance. In RELMβ KO mice, insulin resistance is ameliorated, and lipid accumulation, inflammation, and fibrosis in liver is ameliorated in NASH model, compared with control mice. Furthermore, ELISA system measuring RELMβ is developed, and now investigating RELMβexpression accompanied with change of dietary habitat.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Resistin-like molecule b in foam cells is involved in atherosclerosis development.2013
Author(s)
Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 33
Pages: 1986-1992
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice2013
Author(s)
Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T
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Journal Title
adipocyte
Volume: 2(1)
Pages: 28-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Integrator complex plays an essential role in adipose differentiation.2013
Author(s)
Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.
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Journal Title
Biochem Biophys Res Commun
Volume: 434
Pages: 0-0
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model2012
Author(s)
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
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Journal Title
J Biol Chem
Volume: 287
Pages: 44526-35
DOI
Related Report
Peer Reviewed
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[Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development.2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 32
Pages: 291-298
DOI
Related Report
Peer Reviewed
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[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes.2012
Author(s)
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
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Journal Title
American Journal Physiology Endocrinology and Metabolism
Volume: 302
Pages: 286-296
DOI
Related Report
Peer Reviewed
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[Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications2012
Author(s)
Nakarai, H, Yamashita, A, Nagayasu, S, Iwashita, M, Kumamoto, S, Ohyama, H, Hata, M, Soga, Y, Kushiyama, A, Asano, T, Abiko, Y, Nishimura, F
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Journal Title
Innate Immun
Volume: 18
Pages: 164-170
DOI
Related Report
Peer Reviewed
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[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 andenhances insulin actions and adipogenesis2011
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
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Journal Title
The Journal of Biological Chemistry
Volume: 286
Pages: 20812-2022
DOI
Related Report
Peer Reviewed
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[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity.2011
Author(s)
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
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Journal Title
American Journal of Physiology-Cell Physiology
Volume: 300(5)
Pages: 1047-54
DOI
Related Report
Peer Reviewed
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